Prevalence and factors associated with spontaneous closure of congenital ventricular septal defects.
Journal
La Tunisie medicale
ISSN: 2724-7031
Titre abrégé: Tunis Med
Pays: Tunisia
ID NLM: 0413766
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
entrez:
22
1
2021
pubmed:
23
1
2021
medline:
12
10
2021
Statut:
ppublish
Résumé
Most of congenital ventricular septal defects evolve towards spontaneous closure of different mechanisms depending on their location. To determine the prevalence and factors associated with spontaneous closure of congenital ventricular septal defects. We conducted a retrospective study of 1000 patients diagnosed with congenital ventricular septal defects in our department from January 2000 to December 2017. After an average follow-up of 52.65 months (± 76.93 months), 183 (18.88%) of ventricular septal defects closed spontaneously. The average time for spontaneous closure was 45.78 months (76.34 months). 30.77% of trabecular ventricular septal defects (p<0.05) and 16.93% of perimembranous defects closed spontaneously (p=0.17). 28.5% of perimembranous defects associated with aneurysm formation versus 17.4% of those without associated aneurysm evolved to spontaneous closure (p<0.05). 65.6% of spontaneous closure occured during the first 3 years of life. In multivariate analysis, trabecular site [OR=2.85; CI (2.05-3.97)] and aneurysms of membranous septum [OR=1.9; CI (1.41-2.8)] were independent factors associated with spontaneous closure of defects. The highest VSD closure rate was observed during the first three years of life. Trabecular site and aneurysms tissue of membranous septum were found as independent factors associated with spontaneous closure.
Sections du résumé
BACKGROUND
BACKGROUND
Most of congenital ventricular septal defects evolve towards spontaneous closure of different mechanisms depending on their location.
AIM
OBJECTIVE
To determine the prevalence and factors associated with spontaneous closure of congenital ventricular septal defects.
METHODS
METHODS
We conducted a retrospective study of 1000 patients diagnosed with congenital ventricular septal defects in our department from January 2000 to December 2017.
RESULTS
RESULTS
After an average follow-up of 52.65 months (± 76.93 months), 183 (18.88%) of ventricular septal defects closed spontaneously. The average time for spontaneous closure was 45.78 months (76.34 months). 30.77% of trabecular ventricular septal defects (p<0.05) and 16.93% of perimembranous defects closed spontaneously (p=0.17). 28.5% of perimembranous defects associated with aneurysm formation versus 17.4% of those without associated aneurysm evolved to spontaneous closure (p<0.05). 65.6% of spontaneous closure occured during the first 3 years of life. In multivariate analysis, trabecular site [OR=2.85; CI (2.05-3.97)] and aneurysms of membranous septum [OR=1.9; CI (1.41-2.8)] were independent factors associated with spontaneous closure of defects.
CONCLUSION
CONCLUSIONS
The highest VSD closure rate was observed during the first three years of life. Trabecular site and aneurysms tissue of membranous septum were found as independent factors associated with spontaneous closure.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM