Pediatric Acute B-Cell Lymphoblastic Leukemia Developing Following Recent SARS-CoV-2 Infection.
Journal
Journal of pediatric hematology/oncology
ISSN: 1536-3678
Titre abrégé: J Pediatr Hematol Oncol
Pays: United States
ID NLM: 9505928
Informations de publication
Date de publication:
01 11 2021
01 11 2021
Historique:
received:
31
07
2020
accepted:
11
12
2020
pubmed:
23
1
2021
medline:
9
11
2021
entrez:
22
1
2021
Statut:
ppublish
Résumé
Coronavirus disease-2019 in children has been linked to various clinical presentation, from paucisymptomatic cutaneous eruptions, to multisystemic inflammatory syndrome. We report the case of an 8-year-old boy who presented with persistent fever and pancytopenia, associated to a skin rash. An extensive etiological workup showed a positive serology for severe acute respiratory syndrome coronavirus 2 and Epstein-Barr virus. A few weeks later, type B acute lymphocytic leukemia was diagnosed. This case underlines the polymorphic appearance of coronavirus disease-2019 and the need for critical appraisal.
Identifiants
pubmed: 33480653
doi: 10.1097/MPH.0000000000002064
pii: 00043426-202111000-00036
doi:
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1177-e1180Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Feldstein LR, Rose EB, Randolph AG. Multisystem inflammatory syndrome in children in the United State. N Engl J Med. 2020;383:1794–1795.
Mantovani A, Rinaldi E, Zusi C, et al. Coronavirus disease 2019 (COVID-19) in children and/or adolescents: a meta-analysis. Pediatr Res. 2020. Available at: http://www.nature.com/articles/s41390-020-1015-2 .
Stokes CL, Patel PA, Sabnis HS, et al. Severe COVID-19 disease in two pediatric oncology patients. Pediatr Blood Cancer. 2020;67:28432.
Pérez-Martinez A, Guerra-García P, Melgosa M, et al. Clinical outcome of SARS-CoV-2 infection in immunosuppressed children in Spain. Eur J Pediatr . 2020. Available at: http://link.springer.com/10.1007/s00431-020-03793-3 .
Galván Casas C, Català A, Carretero Hernández G, et al. Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases. Br J Dermatol. 2020;183:71–77.
Marzano AV, Cassano N, Genovese G, et al. Cutaneous manifestations in patients with COVID-19: a preliminary review of an emerging issue. Br J Dermatol. 2020;183:431–442.
Ponvert C, Perrin Y, Bados-Albiero A, et al. Allergy to betalactam antibiotics in children: results of a 20-year study based on clinical history, skin and challenge tests: Betalactam allergy in children: a 20-year study. Pediatr Allergy Immunol. 2011;22:411–418.
Lernia VD, Mansouri Y. Epstein-Barr virus and skin manifestations in childhood. Int J Dermatol. 2013;52:1177–1184.
Orf K, Rogosic S, Dexter D, et al. Remdesivir during induction chemotherapy for newly diagnosed paediatric acute lymphoblastic leukaemia with concomitant SARS‐CoV‐2 infection. Br J Haematol. 2020;190:e274–e276.
Marcia M, Vania B, Pruccoli G, et al. Acute lymphoblastic leukemia onset in a 3‐year‐old child with COVID‐19. Pediatr Blood Cancer. 2020;67:e28423.
Taub JW, Ge Y, Xavier AC. COVID‐19 and childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2020;67:e28400.
Yin H, Qu J, Peng Q, et al. Molecular mechanisms of EBV-driven cell cycle progression and oncogenesis. Med Microbiol Immunol (Berl). 2019;208:573–583.
Martin-Lorenzo A, Hauer J, Vicente-Duenas C, et al. Infection exposure is a causal factor in B-cell precursor acute lymphoblastic leukemia as a result of Pax5-inherited susceptibility. Cancer Discov. 2015;5:1328–1343.
Bartenhagen C, Fischer U, Korn K, et al. Infection as a cause of childhood leukemia: virus detection employing whole genome sequencing. Haematologica. 2017;102:e179–e183.
Whittaker E, Bamford A, Kenny J, et al. Clinical characteristics of 58 children with a pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2. JAMA. 2020;324:259–269.
Mustafa NM, Selim LA. Characterisation of COVID-19 pandemic in paediatric age group: a systematic review and meta-analysis. J Clin Virol. 2020;128:104395.
Auvin S, Dalle J-H, Ganga-Zandzou P-S, et al. Is agranulocytosis following infectious mononucleosis caused by autoimmunity? Pediatr Hematol Oncol. 2003;20:611–615.
Yokoyama T, Tokuhisa Y, Toga A, et al. Agranulocytosis after infectious mononucleosis. J Clin Virol. 2013;56:355–357.