Decarboxylative Polyfluoroarylation of Alkylcarboxylic Acids.
decarboxylation polyfluoroarylation
defluorinative alkylation
late-stage functionalization
photoredox catalysis
radical reaction
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
03 05 2021
03 05 2021
Historique:
received:
23
11
2020
pubmed:
23
1
2021
medline:
23
1
2021
entrez:
22
1
2021
Statut:
ppublish
Résumé
Polyfluoroarenes are useful building blocks in several areas such as drug discovery, materials, and crop protection. Herein, we report the first polyfluoroarylation of aliphatic carboxylic acids via photoredox decarboxylation. The method proceeds with broad substrate scope and high functional group tolerance. Moreover, small complex molecules such as natural products and drugs can be modified by late-stage modification.
Identifiants
pubmed: 33481305
doi: 10.1002/anie.202015596
pmc: PMC8252513
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
10557-10562Informations de copyright
© 2021 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.
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