Adult neural stem cell activation in mice is regulated by the day/night cycle and intracellular calcium dynamics.
Adult Stem Cells
/ cytology
Animals
Astrocytes
/ drug effects
Behavior, Animal
/ drug effects
Calcium
/ metabolism
Cell Division
/ drug effects
Cell Proliferation
/ drug effects
Circadian Rhythm
/ drug effects
Cytosol
/ metabolism
Epidermal Growth Factor
/ pharmacology
Inositol 1,4,5-Trisphosphate Receptors
/ metabolism
Intracellular Space
/ metabolism
Melatonin
/ metabolism
Mice
Neural Stem Cells
/ cytology
Optogenetics
Signal Transduction
/ drug effects
Tryptamines
/ pharmacology
CRISPR-Cas9
Ca(2+) signaling
G-proteins
NSCs
circadian rhythm
in vivo imaging
melatonin
mini-endoscopes
neural stem cells
subventricular zone
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
04 02 2021
04 02 2021
Historique:
received:
08
05
2020
revised:
25
08
2020
accepted:
15
12
2020
pubmed:
23
1
2021
medline:
25
8
2021
entrez:
22
1
2021
Statut:
ppublish
Résumé
Neural stem cells (NSCs) in the adult brain transit from the quiescent state to proliferation to produce new neurons. The mechanisms regulating this transition in freely behaving animals are, however, poorly understood. We customized in vivo imaging protocols to follow NSCs for several days up to months, observing their activation kinetics in freely behaving mice. Strikingly, NSC division is more frequent during daylight and is inhibited by darkness-induced melatonin signaling. The inhibition of melatonin receptors affected intracellular Ca
Identifiants
pubmed: 33482084
pii: S0092-8674(20)31748-7
doi: 10.1016/j.cell.2020.12.026
pii:
doi:
Substances chimiques
Inositol 1,4,5-Trisphosphate Receptors
0
Tryptamines
0
luzindole
117946-91-5
Epidermal Growth Factor
62229-50-9
Melatonin
JL5DK93RCL
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
709-722.e13Subventions
Organisme : CIHR
Pays : Canada
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.