Distinct roles of dorsal and ventral subthalamic neurons in action selection and cancellation.

Aged Female Humans Inhibition, Psychological Male Middle Aged Movement Neurons / physiology Psychomotor Performance / physiology Reaction Time Subthalamic Nucleus / physiology
action cancellation cognitive flexibility human intracranial recordings single-neuron stopping subthalamic nucleus

Journal

Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320

Informations de publication

Date de publication:
03 03 2021
Historique:
received: 17 10 2020
revised: 12 12 2020
accepted: 30 12 2020
pubmed: 23 1 2021
medline: 13 3 2021
entrez: 22 1 2021
Statut: ppublish

Résumé

The subthalamic nucleus (STN) supports action selection by inhibiting all motor programs except the desired one. Recent evidence suggests that STN can also cancel an already selected action when goals change, a key aspect of cognitive control. However, there is little neurophysiological evidence for dissociation between selecting and cancelling actions in the human STN. We recorded single neurons in the STN of humans performing a stop-signal task. Movement-related neurons suppressed their activity during successful stopping, whereas stop-signal neurons activated at low-latencies near the stop-signal reaction time. In contrast, STN and motor-cortical beta-bursting occurred only later in the stopping process. Task-related neuronal properties varied by recording location from dorsolateral movement to ventromedial stop-signal tuning. Therefore, action selection and cancellation coexist in STN but are anatomically segregated. These results show that human ventromedial STN neurons carry fast stop-related signals suitable for implementing cognitive control.

Identifiants

DOI: 10.1016/j.neuron.2020.12.025 PMID: 33482087 PMC: PMC7933114
pubmed: 33482087
pii: S0896-6273(20)31029-1
doi: 10.1016/j.neuron.2020.12.025
pmc: PMC7933114
mid: NIHMS1661640
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

869-881.e6

Subventions

Organisme : NINDS NIH HHS
ID : U01 NS098961
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS103792
Pays : United States
Organisme : NINDS NIH HHS
ID : U01 NS117839
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

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Auteurs

Clayton P Mosher (CP)

Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

Adam N Mamelak (AN)

Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

Mahsa Malekmohammadi (M)

Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Nader Pouratian (N)

Department of Neurosurgery, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Ueli Rutishauser (U)

Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA; Center for Neural Science and Medicine, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Electronic address: ueli.rutishauser@cshs.org.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Distinct roles of dorsal and ventral...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Distinct roles of dorsal and ventral...
questionsmedicales.fr › Phénomènes psychologiques › Théorie psychologique › Théorie psychanalytique › Inhibition (psychologie) › Distinct roles of dorsal and ventral...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Distinct roles of dorsal and ventral...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Mouvement › Distinct roles of dorsal and ventral...
questionsmedicales.fr › Cellules › Neurones › Distinct roles of dorsal and ventral...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Performance psychomotrice › Distinct roles of dorsal and ventral...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Temps de réaction › Distinct roles of dorsal and ventral...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Diencéphale › Subthalamus › Noyau subthalamique › Distinct roles of dorsal and ventral...