To Degrade a MicroRNA, Destroy Its Argonaute Protein.

Argonaute Proteins / genetics MicroRNAs / genetics Proteasome Endopeptidase Complex / metabolism Ubiquitin / metabolism Ubiquitin-Protein Ligases / metabolism

Journal

Molecular cell
ISSN: 1097-4164
Titre abrégé: Mol Cell
Pays: United States
ID NLM: 9802571

Informations de publication

Date de publication:
21 01 2021
Historique:
entrez: 22 1 2021
pubmed: 23 1 2021
medline: 29 1 2021
Statut: ppublish

Résumé

Han et al. (2020) and Shi et al. (2020) report that the E3 ubiquitin ligase ZSWIM8 senses when an RNA and an Argonaute protein-bound microRNA are extensively base paired and directs Argonaute destruction by the proteasome. The result is degradation of the microRNA.

Identifiants

DOI: 10.1016/j.molcel.2020.12.043 PMID: 33482091
pubmed: 33482091
pii: S1097-2765(20)30964-3
doi: 10.1016/j.molcel.2020.12.043
pii:
doi:

Substances chimiques

Argonaute Proteins 0
MicroRNAs 0
Ubiquitin 0
Ubiquitin-Protein Ligases EC 2.3.2.27
Proteasome Endopeptidase Complex EC 3.4.25.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

223-225

Subventions

Organisme : NIGMS NIH HHS
ID : R35 GM136275
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States

Commentaires et corrections

Type : CommentOn
Type : CommentOn

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests P.D.Z. is a member of the advisory board of Molecular Cell. P.D.Z. is an inventor on patents filed by the University of Massachusetts describing the use of highly complementary synthetic oligonucleotides to inhibit microRNA function in cells and in vivo.

Auteurs

Pei-Hsuan Wu (PH)

Howard Hughes Medical Institute and RNA Therapeutics Institute, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA 01605, USA. Electronic address: pei-hsuan.wu@umassmed.edu.

Phillip D Zamore (PD)

Howard Hughes Medical Institute and RNA Therapeutics Institute, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA 01605, USA. Electronic address: phillip.zamore@umassmed.edu.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Protéines de liaison à l'ARN › Ribonucléoprotéines › Complexe réprimant l'expression de l'ARN › Protéines Argonaute › To Degrade a MicroRNA, Destroy Its Argonaute Protein.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › To Degrade a MicroRNA, Destroy Its Argonaute Protein.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Complexes multienzymatiques › Proteasome endopeptidase complex › To Degrade a MicroRNA, Destroy Its Argonaute Protein.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Ubiquitines › Ubiquitine › To Degrade a MicroRNA, Destroy Its Argonaute Protein.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Ubiquitin-protein ligase complexes › Ubiquitin-protein ligases › To Degrade a MicroRNA, Destroy Its Argonaute Protein.