Adult glut3 homozygous null mice survive to demonstrate neural excitability and altered neurobehavioral responses reminiscent of neurodevelopmental disorders.
Glutamate-excitatory neurons
Loss-of-function polymorphisms
Neurodevelopmental disorders
Seizure activity
Journal
Experimental neurology
ISSN: 1090-2430
Titre abrégé: Exp Neurol
Pays: United States
ID NLM: 0370712
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
10
09
2020
revised:
05
01
2021
accepted:
09
01
2021
pubmed:
23
1
2021
medline:
18
9
2021
entrez:
22
1
2021
Statut:
ppublish
Résumé
Since GLUT3 is vital for fueling neurotransmission, we examined in-vivo the adult phenotype carrying the conditional homozygous glut3 gene mutation (KO) in glutamate-excitatory neurons. These KO mice demonstrated sex-specific differences in brain and body weights (p = 0.0001 and p = 0.01 each) with reduced GLUT3 protein in cerebral cortices and brain stem (p = 0.005). In patch clamp studies the glut3 KO mice displayed a shorter latency to and enhanced paroxysmal activity (p = 0.01 and p = 0.015 each) in pyramidal neurons upon application of a GABA
Identifiants
pubmed: 33482226
pii: S0014-4886(21)00008-X
doi: 10.1016/j.expneurol.2021.113603
pmc: PMC8281499
mid: NIHMS1664458
pii:
doi:
Substances chimiques
Glucose Transporter Type 3
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
113603Subventions
Organisme : NICHD NIH HHS
ID : R01 HD041230
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD081206
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Références
Ann Neurol. 2005 Jan;57(1):111-8
pubmed: 15622525
Int Rev Cytol. 1997;172:1-53
pubmed: 9102392
PLoS One. 2016 Feb 22;11(2):e0149900
pubmed: 26901526
Stem Cell Res. 2018 Apr;28:136-140
pubmed: 29477591
J Neurosci Res. 2010 Nov 15;88(15):3386-98
pubmed: 20857507
J Neurosci. 2014 Aug 20;34(34):11180-7
pubmed: 25143599
JAMA Neurol. 2013 Nov;70(11):1440-4
pubmed: 23999624
Endocrinology. 2017 Apr 1;158(4):936-949
pubmed: 28324109
Pharmacol Ther. 2018 Oct;190:91-104
pubmed: 29763648
Pflugers Arch. 2004 Feb;447(5):480-9
pubmed: 12750891
J Cell Physiol. 2020 Dec;235(12):9021-9036
pubmed: 32372501
Am J Physiol Endocrinol Metab. 2007 May;292(5):E1241-55
pubmed: 17213475
Birth Defects Res A Clin Mol Teratol. 2015 Apr;103(4):235-42
pubmed: 25250690
Mol Psychiatry. 2010 Mar;15(3):286-99
pubmed: 19506559
J Neurosci. 2018 Oct 31;38(44):9579-9599
pubmed: 30232223
Am J Physiol Regul Integr Comp Physiol. 2004 Feb;286(2):R273-82
pubmed: 14525722
Brain Res. 1999 Mar 27;823(1-2):113-28
pubmed: 10095018
Genes Brain Behav. 2020 Jul;19(6):e12660
pubmed: 32348611
Front Mol Neurosci. 2018 Dec 04;11:445
pubmed: 30564099
Curr Neurol Neurosci Rep. 2013 Apr;13(4):342
pubmed: 23443458
J Neurosci Res. 2020 May;98(5):902-920
pubmed: 31840315
Mol Genet Metab. 2014 Apr;111(4):477-83
pubmed: 24529979
Cereb Cortex. 2001 Dec;11(12):1191-8
pubmed: 11709490
Hum Mutat. 2014 Feb;35(2):248-56
pubmed: 24178905
J Child Psychol Psychiatry. 2017 Jul;58(7):798-809
pubmed: 28224622
Nat Rev Neurosci. 2012 Feb 15;13(3):169-82
pubmed: 22334212
PLoS One. 2020 Oct 15;15(10):e0240810
pubmed: 33057383
J Neurosci. 2009 Aug 19;29(33):10371-86
pubmed: 19692612
J Neurosci. 2009 Mar 4;29(9):2997-3008
pubmed: 19261894
Int J Mol Sci. 2012 Oct 03;13(10):12629-55
pubmed: 23202918
J Neurosci. 2002 Aug 1;22(15):6309-14
pubmed: 12151506
Am J Obstet Gynecol. 2014 Sep;211(3):305.e1-8
pubmed: 24813597
Brain Res Dev Brain Res. 1992 May 22;67(1):95-103
pubmed: 1379128
Mol Psychiatry. 2011 Jan;16(1):97-107
pubmed: 19786962
Nat Genet. 2001 Mar;27(3):327-31
pubmed: 11242118
J Alzheimers Dis. 2017;55(4):1307-1320
pubmed: 27858715
Philos Trans R Soc Lond B Biol Sci. 1999 Jul 29;354(1387):1155-63
pubmed: 10466143