In vivo performance of Al
Bone formation
Composites
In vivo
Orthopedic biomaterials
Osteocytes
Journal
Journal of orthopaedic surgery and research
ISSN: 1749-799X
Titre abrégé: J Orthop Surg Res
Pays: England
ID NLM: 101265112
Informations de publication
Date de publication:
22 Jan 2021
22 Jan 2021
Historique:
received:
06
10
2020
accepted:
11
01
2021
entrez:
23
1
2021
pubmed:
24
1
2021
medline:
13
7
2021
Statut:
epublish
Résumé
Alumina-titanium (Al The aim of the present study was to evaluate the in vivo biological interaction of Al The histological observation showed the formation of osteoblast, osteocytes with lacuna, bone with lamellar structures, and blood vessels indicating that the healing and remodeling of the bone, and vasculature reconstruction occurred after 4 and 8 weeks of implantation. However, superior bone formation and maturation were obtained after 8 weeks. SEM images also showed stronger interfaces at week 8. There were differences between the composites in percentages of bone area (TB%) and the number of osteocytes. The 50Ti composite showed higher TB% at week 4, while 25Ti and 75Ti represented higher TB% at week 8. All the composites showed a higher number of osteocytes compared to 100Ti, particularly 75Ti. The fabricated composites have the potential to be used in load-bearing orthopedic applications.
Sections du résumé
BACKGROUND
BACKGROUND
Alumina-titanium (Al
METHODS
METHODS
The aim of the present study was to evaluate the in vivo biological interaction of Al
RESULTS
RESULTS
The histological observation showed the formation of osteoblast, osteocytes with lacuna, bone with lamellar structures, and blood vessels indicating that the healing and remodeling of the bone, and vasculature reconstruction occurred after 4 and 8 weeks of implantation. However, superior bone formation and maturation were obtained after 8 weeks. SEM images also showed stronger interfaces at week 8. There were differences between the composites in percentages of bone area (TB%) and the number of osteocytes. The 50Ti composite showed higher TB% at week 4, while 25Ti and 75Ti represented higher TB% at week 8. All the composites showed a higher number of osteocytes compared to 100Ti, particularly 75Ti.
CONCLUSIONS
CONCLUSIONS
The fabricated composites have the potential to be used in load-bearing orthopedic applications.
Identifiants
pubmed: 33482866
doi: 10.1186/s13018-021-02226-7
pii: 10.1186/s13018-021-02226-7
pmc: PMC7821505
doi:
Substances chimiques
Biocompatible Materials
0
Titanium
D1JT611TNE
Aluminum Oxide
LMI26O6933
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
79Subventions
Organisme : Semnan University of Medical Sciences
ID : 1310
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