Deubiquitylating enzymes in neuronal health and disease.
Journal
Cell death & disease
ISSN: 2041-4889
Titre abrégé: Cell Death Dis
Pays: England
ID NLM: 101524092
Informations de publication
Date de publication:
22 01 2021
22 01 2021
Historique:
received:
24
11
2020
accepted:
16
12
2020
revised:
15
12
2020
entrez:
23
1
2021
pubmed:
24
1
2021
medline:
5
10
2021
Statut:
epublish
Résumé
Ubiquitylation and deubiquitylation play a pivotal role in protein homeostasis (proteostasis). Proteostasis shapes the proteome landscape in the human brain and its impairment is linked to neurodevelopmental and neurodegenerative disorders. Here we discuss the emerging roles of deubiquitylating enzymes in neuronal function and survival. We provide an updated perspective on the genetics, physiology, structure, and function of deubiquitylases in neuronal health and disease.
Identifiants
pubmed: 33483467
doi: 10.1038/s41419-020-03361-5
pii: 10.1038/s41419-020-03361-5
pmc: PMC7822931
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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