Halo-fluorescein for photodynamic bacteria inactivation in extremely acidic conditions.
Acids
/ chemistry
Animals
Anti-Bacterial Agents
/ pharmacology
Bacteria
/ classification
Female
Fluorescein
/ chemistry
Halogenation
Humans
Hydrogen-Ion Concentration
Light
Mice, Inbred ICR
Microbial Viability
/ drug effects
Molecular Structure
Photosensitizing Agents
/ pharmacology
Singlet Oxygen
/ chemistry
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
22 01 2021
22 01 2021
Historique:
received:
25
11
2019
accepted:
22
12
2020
entrez:
23
1
2021
pubmed:
24
1
2021
medline:
9
2
2021
Statut:
epublish
Résumé
Aciduric bacteria that can survive in extremely acidic conditions (pH < 4.0) are challenging to the current antimicrobial approaches, including antibiotics and photodynamic bacteria inactivation (PDI). Here, we communicate a photosensitizer design concept of halogenation of fluorescein for extremely acidic PDI. Upon halogenation, the well-known spirocyclization that controls the absorption of fluorescein shifts to the acidic pH range. Meanwhile, the heavy atom effect of halogens boosts the generation of singlet oxygen. Accordingly, several photosensitizers that could work at even pH < 2.0 were discovered for a broad band of aciduric bacteria families, with half maximal inhibitory concentrations (IC
Identifiants
pubmed: 33483514
doi: 10.1038/s41467-020-20869-8
pii: 10.1038/s41467-020-20869-8
pmc: PMC7822816
doi:
Substances chimiques
Acids
0
Anti-Bacterial Agents
0
Photosensitizing Agents
0
Singlet Oxygen
17778-80-2
Fluorescein
TPY09G7XIR
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
526Références
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