Comparison of house dust mite sensitization profiles in allergic adults from Canada, Europe, South Africa and USA.
Der p 23
Der p 7
IgE sensitization
allergen exposure
allergen microarray
Journal
Allergy
ISSN: 1398-9995
Titre abrégé: Allergy
Pays: Denmark
ID NLM: 7804028
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
revised:
22
12
2020
received:
17
09
2020
accepted:
03
01
2021
pubmed:
24
1
2021
medline:
10
8
2021
entrez:
23
1
2021
Statut:
ppublish
Résumé
Sensitization to house dust mite (HDM) is a leading cause of allergic rhinitis and asthma. Despite more than 30 HDM-derived allergens having been identified to date, specific therapeutic approaches do not yet take into account the local sensitization profiles of patients. This study aimed to identify patterns of HDM sensitization in HDM-allergic adults living in distinct geographic areas, to inform the development of targeted diagnostic and therapeutic tools. Serum samples from 685 HDM-allergic subjects from Canada, Europe, South Africa, and the USA were tested for levels of IgE specific for 17 micro-arrayed HDM allergens by ImmunoCAP Immuno Solid-phase Allergen Chip (ISAC) technology. The results confirmed significant geographical variability in sensitization patterns and levels of IgE. In all areas, the major sensitizers were the group 1 and group 2 allergens and Der p 23. Der p 23 was a frequent sensitizer: 64% of the subjects had IgE specific for Der p 23, and 2.3% were monosensitized to it. In South Africa, Der p 23 was the dominant HDM allergen (86% prevalence) and Der p 7 achieved major allergen status (56%). IgE sensitization to HDM was influenced by asthmatic status, levels of allergen exposure, age, race-ethnicity and smoking status, but not by BMI. Sensitization profiles to HDM allergens differ considerably among distinct geographic areas, with Der p 7 and Der p 23 being major sensitizers in South Africa. Such heterogeneity should be taken into account in the diagnosis and treatment of HDM-allergic patients.
Sections du résumé
BACKGROUND
Sensitization to house dust mite (HDM) is a leading cause of allergic rhinitis and asthma. Despite more than 30 HDM-derived allergens having been identified to date, specific therapeutic approaches do not yet take into account the local sensitization profiles of patients. This study aimed to identify patterns of HDM sensitization in HDM-allergic adults living in distinct geographic areas, to inform the development of targeted diagnostic and therapeutic tools.
METHODS
Serum samples from 685 HDM-allergic subjects from Canada, Europe, South Africa, and the USA were tested for levels of IgE specific for 17 micro-arrayed HDM allergens by ImmunoCAP Immuno Solid-phase Allergen Chip (ISAC) technology.
RESULTS
The results confirmed significant geographical variability in sensitization patterns and levels of IgE. In all areas, the major sensitizers were the group 1 and group 2 allergens and Der p 23. Der p 23 was a frequent sensitizer: 64% of the subjects had IgE specific for Der p 23, and 2.3% were monosensitized to it. In South Africa, Der p 23 was the dominant HDM allergen (86% prevalence) and Der p 7 achieved major allergen status (56%). IgE sensitization to HDM was influenced by asthmatic status, levels of allergen exposure, age, race-ethnicity and smoking status, but not by BMI.
CONCLUSION
Sensitization profiles to HDM allergens differ considerably among distinct geographic areas, with Der p 7 and Der p 23 being major sensitizers in South Africa. Such heterogeneity should be taken into account in the diagnosis and treatment of HDM-allergic patients.
Substances chimiques
Allergens
0
Antigens, Dermatophagoides
0
Dust
0
Immunoglobulin E
37341-29-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2177-2188Informations de copyright
© 2021 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
Références
Arlian LG, Platts-Mills TAE. The biology of dust mites and the remediation of mite allergens in allergic disease. J Allergy Clin Immunol. 2001;107(3):S406-S413.
Calderon MA, Linneberg A, Kleine-Tebbe J, et al. Respiratory allergy caused by house dust mites: what do we really know? J Allergy Clin Immunol. 2015;136(1):38-48.
WHO/IUIS Allergen Nomenclature Sub-Committee. Allergen nomenclature. http://www.allergen.org. Accessed May 4, 2020.
Thomas WR. IgE and T-cell responses to house dust mite allergen components. Mol Immunol. 2018;100:120-125.
Hales BJ, Martin AC, Pearce LJ, et al. IgE and IgG anti-house dust mite specificities in allergic disease. J Allergy Clin Immunol. 2006;118(2):361-367.
Mueller GA, Randall TA, Glesner J, et al. Serological, genomic and structural analyses of the major mite allergen Der p 23. Clin Exp Allergy. 2016;46(2):365-376.
Barber D, Arias J, Boquete M, et al. Analysis of mite allergic patients in a diverse territory by improved diagnostic tools. Clin Exp Allergy. 2012;42(7):1129-1138.
Weghofer M, Grote M, Resch Y, et al. Identification of Der p 23, a peritrophin-like protein, as a new major dermatophagoides pteronyssinus allergen associated with the peritrophic matrix of mite fecal pellets. J Immunol. 2013;190(7):3059-3067.
Soh WT, Le Mignon M, Suratannon N, et al. The house dust mite major allergen der p 23 displays O-glycan-independent IgE reactivities but no chitin-binding activity. Int Arch Allergy Immunol. 2016;168(3):150-160.
Resch Y, Michel S, Kabesch M, Lupinek C, Valenta R, Vrtala S. Different IgE recognition of mite allergen components in asthmatic and nonasthmatic children. J Allergy Clin Immunol. 2015;136(4):1083-1091.
Posa D, Perna S, Resch Y, et al. Evolution and predictive value of IgE responses toward a comprehensive panel of house dust mite allergens during the first 2 decades of life. J Allergy Clin Immunol. 2017;139(2):541.
Becker S, Schlederer T, Kramer MF, et al. Real-life study for the diagnosis of house dust mite allergy - the value of recombinant allergen-based IgE serology. Int Arch Allergy Immunol. 2016;170(2):132-137.
Batard T, Baron-Bodo V, Martelet A, et al. Patterns of IgE sensitization in house dust mite-allergic patients: implications for allergen immunotherapy. Allergy 2015;71(2):220-229.
Thomas WR. House dust mite allergens: new discoveries and relevance to the allergic patient. Curr Allergy Asthma Rep. 2016;16(9):69.
Partridge MR, van der Molen T, Myrseth S-E, Busse WW. Attitudes and actions of asthma patients on regular maintenance therapy: the INSPIRE study. BMC Pul Med. 2006;6(1):13.
Calderon MA, Bousquet J, Canonica GW, et al. Guideline recommendations on the use of allergen immunotherapy in house dust mite allergy: time for a change? J Allergy Clin Immunol. 2017;140(1):41-52.
Agache I, Lau S, Akdis CA, et al. EAACIGuidelines on allergen immunotherapy: house dust mite-driven allergic asthma. Allergy. 2019;74(5):855-873.
Demoly P, Emminger W, Rehm D, Backer V, Tommerup L, Kleine-Tebbe J. Effective treatment of house dust mite-induced allergic rhinitis with 2 doses of the SQ HDM SLIT-tablet: results from a randomized, double-blind, placebo-controlled phase III trial. J Allergy Clin Immunol. 2016;137(2):444.
Virchow JC, Backer V, Kuna P, et al. Efficacy of a house dust mite sublingual allergen immunotherapy tablet in adults with allergic asthma: a randomized clinical trial. JAMA. 2016;315(16):1715-1725.
Huang F-L, Liao E-C, Yu S-J. House dust mite allergy: its innate immune response and immunotherapy. Immunobiology. 2018;223(3):300-302.
Casset A, Mari A, Purohit A, et al. Varyingallergen composition and content affects the in vivo allergenic activity of commercial dermatophagoides pteronyssinus extracts. Int Arch Allergy Immunol. 2012;159(3):253-262.
Brunetto B, Tinghino R, Braschi MC, Antonicelli L, Pini C, Iacovacci P. Characterization and comparison of commercially available mite extracts for in vivodiagnosis. Allergy. 2010;65(2):184-190.
Meyer CH, Bond JF, Chen MS, Kasaian MT. Comparison of the levels of the major allergens Der pI and Der pII in standardized extracts of the house dust mite, Dermatophagoides pteronyssinus. Clin Exp Allergy. 1994;24(11):1041-1048.
Chen KW, Zieglmayer P, Zieglmayer R, et al. Selection of house dust mite-allergic patients by molecular diagnosis may enhance success of specific immunotherapy. J Allergy Clin Immunol. 2019;143(3):1248.
Rodríguez-Domínguez A, Berings M, Rohrbach A, et al. Molecular profiling of allergen-specific antibody responses may enhance success of specific immunotherapy. J Allergy Clin Immunol. 2020;146(5):1097-1108.
Lupinek C, Wollmann E, Baar A, et al. Advances in allergen-microarray technology for diagnosis and monitoring of allergy: the MeDALL allergen-chip. Methods. 2014;66(1):106-119.
Earle CD, King EM, Tsay A, et al. High-throughput fluorescent multiplex array for indoor allergen exposure assessment. J Allergy Clin Immunol. 2007;119(2):428-433.
King EM, Filep S, Smith B, et al. A multi-center ring trial of allergen analysis using fluorescent multiplex array technology. J Immunol Methods. 2013;387(1):89-95.
Weghofer M, Thomas WR, Kronqvist M, et al. Variability of IgE reactivity profiles among European mite allergic patients. Eur J Clin Invest. 2008;38(12):959-965.
Platts-Mills T, De Weck A, Aalberse R, et al. Dust mite allergens and asthma-A worldwide problem. J Allergy Clin Immunol. 1989;83(2):416-427.
Jarvis D, Luczynska C, Chinn S, Burney P. The association of age, gender and smoking with total IgE and specific IgE. Clin Exp Allergy. 1995;25(11):1083-1091.
Hjellvik V, Tverdal A, Furu K. Body mass index as predictor for asthma: a cohort study of 118,723 males and females. Eur Respir J. 2010;35(6):1235.
Zhernov Y, Curin M, Khaitov M, Karaulov A, Valenta R. Recombinant allergens for immunotherapy: state of the art. CurrOpin Allergy Clin Immunol. 2019;19(4):402-414.
Dorofeeva Y, Shilovskiy I, Tulaeva I, et al. Past, presence, and future of allergen immunotherapy vaccines. Allergy. 2020;9(4):1.
Celi G, Brusca I, Scala E, et al. House dust mite allergy in Italy-Diagnostic and clinical relevance of Der p 23 (and of minor allergens): a real-life, multicenter study. Allergy. 2019;74(9):1787-1789.
Custovic A, Sonntag H-J, Buchan IE, Belgrave D, Simpson A, Prosperi MCF. Evolution pathways of IgE responses to grass and mite allergens throughout childhood. J Allergy Clin Immunol. 2015;136(6):1645-1648.
Pomes A, Glesner J, Calatroni A, et al. Cockroach allergen component analysis of children with or without asthma and rhinitis in an inner-city birth cohort. J Allergy Clin Immunol. 2019;144(4):935-944.
De Amici M, Ciprandi G. The age impact on serum total and allergen-specific IgE. Allergy Asthma Immunol Res. 2013;5(3):170-174.
Matos Semedo F, Dorofeeva Y, Pires AP, et al. Der p 23: clinical relevance of molecular monosensitization in house dust mite allergy. J InvestigAllergol Clin Immunol. 2019;29(4):314-316.
Jiménez-Feijoo R, Pascal M, Moya R, et al. Molecular diagnosis in house dust mite allergic patients suggests clinical relevance of Der p 23 in asthmatic children. J InvestigAllergol Clin Immunol. 2019;30(4):127-132.
Rowntree S, Cogswell JJ, Platts-Mills TA, Mitchell EB. Development of IgE and IgG antibodies to food and inhalant allergens in children at risk of allergic disease. Arch Dis Child. 1985;60(8):727.
Lau S, Falkenhorst G, Weber A, et al. High mite-allergen exposure increases the risk of sensitization in atopic children and young adults. J Allergy Clin Immunol. 1989;84(5):718-725.
Sporik R, Holgate ST, Platts-Mills TAE, Cogswell JJ. Exposure to house-dust mite allergen (Der pI) and the development of asthma in childhood. N Engl J Med. 1990;323(8):502-507.
Niederberger V, Ring J, Rakoski J, et al. Antigens drive memory IgE responses in human allergy via the nasal mucosa. Int Arch Allergy Immunol. 2007;142(2):133-144.
Platts-Mills T, Vaughan J, Squillace S, Woodfolk J, Sporik R. Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study. Lancet. 2001;357(9258):752-756.
Almqvist C. High allergen exposure as a risk factor for asthma and allergic disease. Clinic Rev Allerg Immunol. 2005;28(1):25-41.
Burrows B, Halonen M, Barbee RA, Lebowitz MD. The relationship of serum immunoglobulin E to cigarette smoking. Am Rev Respir Dis. 1981;124(5):523-525.
Warren CPW, Holford-Strevens V, Wong C, Manfreda J. The relationship between smoking and total immunoglobulin E levels. J Allergy Clin Immunol. 1982;69(4):370-375.
Omenaas E, Bakke P, Elsayed S, Hanoa R, Gulsvik A. Total and specific serum IgE levels in adults: relationship to sex, age and environmental factors. Clin Exp Allergy. 1994;24(6):530-539.
Wollmann E, Lupinek C, Kundi M, Selb R, Niederberger V, Valenta R. Reduction in allergen-specific IgE binding as measured by microarray: a possible surrogate marker for effects of specific immunotherapy. J Allergy Clin Immunol. 2015;136(3):806-807.
Curin M, Swoboda I, Wollmann E, et al. Microarrayed dog, cat, and horse allergens show weak correlation between allergen-specific IgE and IgG responses. J Allergy Clin Immunol. 2014;133(3):918.
Siroux V, Lupinek C, Resch Y, et al. Specific IgE and IgG measured by the MeDALL allergen-chip depend on allergen and route of exposure: the EGEA study. J Allergy Clin Immunol. 2017;139(2):643-646.
Kanthawatana S, Maturim W, Fooanan S, Trakultivakorn M. Skin prick reaction and nasal provocation response in diagnosis of nasal allergy to the house dust mite. Ann Allergy Asthma Immunol. 1997;79(5):427-430.
Mersha TB, Abebe T. Self-reported race/ethnicity in the age of genomic research: its potential impact on understanding health disparities. Hum Genomics. 2015;9(1):1.