Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia in conjunction with parotid basal cell adenoma: Cytologic, histologic, and molecular features.
cytopathology
fine-needle aspiration
parotid
sclerosing mucoepidermoid carcinoma
thyroid
Journal
Diagnostic cytopathology
ISSN: 1097-0339
Titre abrégé: Diagn Cytopathol
Pays: United States
ID NLM: 8506895
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
revised:
21
12
2020
received:
02
10
2020
accepted:
11
01
2021
pubmed:
24
1
2021
medline:
15
12
2021
entrez:
23
1
2021
Statut:
ppublish
Résumé
Sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) is a rare malignancy in the thyroid: only 56 cases with histologic descriptions are reported in the literature and fewer reports describe the cytomorphology. Given the rarity of SMECE, data on the cytomorphologic and molecular features are limited. We report a case of a 53-year-old woman with a 5 cm left thyroid mass. Fine-needle aspiration (FNA) revealed atypia of undetermined significance and pathology of left thyroid lobectomy specimen showed SMECE. Additionally, a left pre-auricular lump was noted and FNA followed by left superficial parotidectomy showed basal cell adenoma. Next-generation sequencing showed point mutations in NTRK3 and NF1. Unlike salivary gland mucoepidermoid carcinoma, MAML2 translocations are not present in SMECE. Even though it is a rare entity, awareness of SMECE of the thyroid is important. In this case report we review the cytomorphologic, histologic, and molecular features.
Substances chimiques
NF1 protein, human
0
NTRK3 protein, human
0
Neurofibromin 1
0
Receptor, trkC
EC 2.7.10.1
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
E262-E268Informations de copyright
© 2021 Wiley Periodicals LLC.
Références
Chan JK, Albores-Saavedra J, Battifora H, Carcangiu ML, Rosai J. Sclerosing mucoepidermoid thyroid carcinoma with eosinophilia. A distinctive low-grade malignancy arising from the metaplastic follicles of hashimoto's thyroiditis. Am J Surg Pathol. 1991;15(5):438-448.
Chambers M, Nosé V, Sadow PM, Tafe LJ, Kerr DA. Salivary-like tumors of the thyroid: a comprehensive review of three rare carcinomas. Head Neck Pathol. 2020. https://doi.org/10.1007/s12105-020-01193-5.
Ames E, Campbell MJ, Afify A, Krane JF, Huang EC. Sclerosing mucoepidermoid carcinoma with eosinophilia: Cytologic characterization of a rare distinct entity in the thyroid. Diagn Cytopathol. 2018;46(7):632-635. https://doi.org/10.1002/dc.23914.
Bondeson L, Bondeson AG. Cytologic features in fine-needle aspirates from a sclerosing mucoepidermoid thyroid carcinoma with eosinophilia. Diagn Cytopathol. 1996;15(4):301-305.
Hirokawa M, Takada N, Abe H, et al. Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia distinct from the salivary type. Endocr J. 2018;65(4):427-436. https://doi.org/10.1507/endocrj.EJ17-0462.
Geisinger KR, Steffee CH, McGee RS, Woodruff RD, Buss DH. The cytomorphologic features of sclerosing mucoepidermoid carcinoma of the thyroid gland with eosinophilia. Am J Clin Pathol. 1998;109(3):294-301. https://doi.org/10.1093/ajcp/109.3.294.
Pantola C, Kala S, Athar M, Thakur S. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: a cytological dilemma. J Cytol. 2016;33(1):37-39.
Wiles AB, Kraft AO, Mueller SM, Powers CN. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: case report of a rare lesion with novel genetic mutation. Diagn Cytopathol. 2019;47(6):589-593. https://doi.org/10.1002/dc.24148.
Nam JH, Han CW, Kim NI, Kim SS, Choi YD. The cytological features of sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid gland: a case report. Cytopathology. 2020;31:593-597. https://doi.org/10.1111/cyt.12889.
Lai CY, Chao TC, Lin JD, Hsueh C. Sclerosing mucoepidermoid carcinoma with eosinophilia of thyroid gland in a male patient: a case report and literature review. Int J Clin Exp Pathol. 2015;8(5):5947-5951.
Das S, Kalyani R. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid. Indian J Pathol Microbiol. 2008;51(1):34-36. https://doi.org/10.4103/0377-4929.40389.
Iftikhar H, Awan MS, Ghaloo SK, Fatima S. Sclerosing mucoepidermoid carcinoma with eosinophilia of thyroid. BMJ Case Rep. 2019;12(8):e225685.
Minagawa A, Iitaka M, Suzuki M, et al. A case of primary mucoepidermoid carcinoma of the thyroid: molecular evidence of its origin. Clin Endocrinol (Oxf). 2002;57(4):551-556.
Baloch ZW, Solomon AC, LiVolsi VA. Primary mucoepidermoid carcinoma and sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid gland: a report of nine cases. Mod Pathol. 2000;13(7):802-807. https://doi.org/10.1038/modpathol.3880140.
Shah AA, La Fortune K, Miller C, et al. Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia: a clinicopathologic and molecular analysis of a distinct entity. Mod Pathol. 2017;30(3):329-339.
Sim SJ, Ro JY, Ordonez NG, Cleary KR, Ayala AG. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: report of two patients, one with distant metastasis, and review of the literature. Hum Pathol. 1997;28(9):1091-1096.doi: S0046-8177(97)90064-2 [pii].
Chung J, Lee SK, Gong G, et al. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid glands: a case report with clinical manifestation of recurrent neck mass. J Korean Med Sci. 1999;14(3):338-341. https://doi.org/10.3346/jkms.1999.14.3.338.
Shehadeh NJ, Vernick J, Lonardo F, et al. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: a case report and review of the literature. Am J Otolaryngol. 2004;25(1):48-53.
Quiroga-Garza G, Lee JH, El-Naggar A, et al. Sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid: more aggressive than previously reported. Hum Pathol. 2015;46(5):725-731.
Tasaki T, Matsuyama A, Tabata T, et al. Sclerosing mucoepidermoid carcinoma with eosinophilia of the salivary gland: case report and review of the literature. Pathol Int. 2013;63(2):125-131. https://doi.org/10.1111/pin.12035.
Hunt JL, LiVolsi VA, Barnes EL. P63 expression in sclerosing mucoepidermoid carcinomas with eosinophilia arising in the thyroid. Mod Pathol. 2004;17(5):526-529.
Solomon AC, Baloch ZW, Salhany KE, Mandel S, Weber RS, LiVolsi VA. Thyroid sclerosing mucoepidermoid carcinoma with eosinophilia: mimic of hodgkin disease in nodal metastases. Arch Pathol Lab Med. 2000;124(3):446-449.
Cantley RL. Fine-needle aspiration cytology of cellular basaloid neoplasms of the salivary gland. Arch Pathol Lab Med. 2019;143(11):1338-1345. https://doi.org/10.5858/arpa.2019-0327-RA.
Jurczyk M, Peevey JF, Vande Haar MA, Lin X. Pitfalls of fine-needle aspiration cytology of parotid membranous basal cell adenoma-a review of pitfalls in FNA cytology of salivary gland neoplasms with basaloid cell features. Diagn Cytopathol. 2015;43(5):432-437. https://doi.org/10.1002/dc.23234.
Avadhani V, Cohen C, Siddiqui MT. PLAG1: an immunohistochemical marker with limited utility in separating pleomorphic adenoma from other basaloid salivary gland tumors. Acta Cytol. 2016;60(3):240-245.
Griffith CC, Siddiqui MT, Schmitt AC. Ancillary testing strategies in salivary gland aspiration cytology: a practical pattern-based approach. Diagn Cytopathol. 2017;45(9):808-819. https://doi.org/10.1002/dc.23715.
Sato M, Yamamoto H, Hatanaka Y, et al. Wnt/β-catenin signal alteration and its diagnostic utility in basal cell adenoma and histologically similar tumors of the salivary gland. Pathol Res Pract. 2018;214(4):586-592.
Schmitt AC, Griffith CC, Cohen C, Siddiqui MT. LEF-1: diagnostic utility in distinguishing basaloid neoplasms of the salivary gland. Diagn Cytopathol. 2017;45(12):1078-1083. https://doi.org/10.1002/dc.23820.
Sukumar JS, Sukumar S, Purohit D, et al. Activating BRAF mutation in sclerosing mucoepidermoid carcinoma with eosinophilia of the thyroid gland: two case reports and review of the literature. J Med Case Rep. 2019;13(1):385-380. https://doi.org/10.1186/s13256-019-2288-0.