Stem cells therapy in acute myocardial infarction: a new era?
Acute myocardial infarction
Bone marrow cells
Clinical trials
Stem cells
Transplantation
Journal
Clinical and experimental medicine
ISSN: 1591-9528
Titre abrégé: Clin Exp Med
Pays: Italy
ID NLM: 100973405
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
30
09
2020
accepted:
04
01
2021
pubmed:
24
1
2021
medline:
23
11
2021
entrez:
23
1
2021
Statut:
ppublish
Résumé
Stem cells transplantation after acute myocardial infarction (AMI) has been claimed to restore cardiac function. However, this therapy is still restricted to experimental studies and clinical trials. Early un-blinded studies suggested a benefit from stem cell therapy following AMI. More recent blinded randomized trials have produced mixed results and, notably, the last largest pan-European clinical trial showed the inconclusive results. Furthermore, mechanisms of potential benefit remain uncertain. This review analytically evaluates 34 blinded and un-blinded clinical trials comprising 3142 patients and is aimed to: (1) identify the pros and cons of stem cell therapy up to a 6-month follow-up after AMI comparing benefit or no effectiveness reported in clinical trials; (2) provide useful information for planning future clinical programs of cardiac stem cell therapy.
Identifiants
pubmed: 33484381
doi: 10.1007/s10238-021-00682-3
pii: 10.1007/s10238-021-00682-3
pmc: PMC8053645
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
231-237Références
Thum T, Bauersachs J, Poole-Wilson PA, Volk HD, Anker SD. The dying stem hypothesis: immune modulation as a novel mechanism for progenitor cell therapy in cardiac muscle. J Am Coll Cardiol. 2005;46:1799–802.
pubmed: 16286162
Orlic D, Kajstura J, Chimenti S, et al. Bone marrow cells regenerate infarcted myocardium. Nature. 2001;410:701–51.
pubmed: 11287958
Gnecchi M, He H, Liang OD, et al. Paracrine action accounts for marked protection of ischemic heart by AKT-modified mesenchymal stem cells. Nat Med. 2005;11:367–8.
pubmed: 15812508
Hodgkinson CP, Bareja A, Gomez JA, Dzau VJ. Emerging concepts in paracrine mechanisms in regenerative cardiovascular medicine and biology. Circ Res. 2016;118:95–107.
pubmed: 26837742
pmcid: 4874329
Anversa P, Leri A, Kajstura J. Cardiac regeneration. J Am Coll Cardiol. 2006;47:1769–76.
pubmed: 16682300
Plotnikov EY, Silachev DN, Popkov VA, et al. Intercellular signalling cross-talk: to kill, to heal and to rejuvenate. Heart Lung Circ. 2017;26:648–59.
pubmed: 28190758
Colliva A, Braga L, Giacca M, Zacchigna S. Endothelial cell–cardiomyocyte crosstalk in heart development and disease. J Physiol. 2020;598:2923–39.
pubmed: 30816576
Strauer BE, Brehm M, Zeus T, et al. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation. 2002;106:1913–8.
pubmed: 12370212
Assmus B, Schächinger V, Teupe C, et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE–AMI). Circulation. 2002;106:3009–17.
pubmed: 12473544
Britten MB, Abolmaali ND, Assmus B, et al. Infarction remodeling after intracoronary progenitor cell treatment in patients with acute myocardial infarction (TOPCARE-AMI): mechanistic insight from serial contrast-enhanced magnetic resonance imaging. Circulation. 2003;108:2212–8.
pubmed: 14557356
Strauer BE, Brehem M, Zeus T, et al. Regeneration of human infarcted heart muscle by intracoronary autologous bone marrow cell transplantation in chronic coronary artery disease: the IACT study. J Am Cell Cardiol. 2005;46:1651–8.
Tse HF, Kwong YL, Chan Lo G, Ho CL, Lau CP. Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell transplantation. Lancet. 2003;361:47–9.
pubmed: 12517468
Perin EC, Dohmann HF, Borojevic R, et al. Transendocardial, autologous bone marrow cell transplantation for severe chronic ischemic heart failure. Circulation. 2003;107:2294–302.
pubmed: 12707230
Perin EC, Dohmann HF, Borojevic R, et al. Improved exercise capacity and ischemia 6 and 12 months after transendocardial injection of autologous bone marrow mononuclear cells for ischemic cardiomyopathy. Circulation. 2004;110(11 Suppl 1):213–8.
Fuchs S, Satler LF, Kornowski R, et al. Catheter-based autologous bone marrow myocardial injection in no-option patients with advanced coronary artery disease: a feasibility study. J Am Coll Cardiol. 2003;41:1721–4.
pubmed: 12767654
Wollert KC, Meyer GP, Lotz J, et al. Intracoronary autologous bone-marrow cell transfer after mycocardial infarction: the BOOST randomised controlled clinical trial. Lancet. 2004;364:141–8.
pubmed: 15246726
Ince H, Petzsch M, Kleine HD, et al. Preservation from left ventricular remodeling by front-integrated revascularization and stem cell liberation in evolving acute myocardial infarction by use of granulocyte-colony-stimulating factor (FIRSTLINE-AMI). Circulation. 2005;112:3097–106.
pubmed: 16275869
Kang HJ, Kim HS, Zhang SY, et al. Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte –colony stimulating factor on left ventricular systolic function restenosis after coronary stenting in myocardial infarction: the MAGIC cell randomized clinical trial. Lancet. 2004;363:751–6.
pubmed: 15016484
Achilli F, Pontone G, Bassetti B, et al. Stem-AMI outcome CMR Sub-Study Investigators. G-CSF for extensive STEMI. Circ Res. 2019;125:295–306.
pubmed: 31138020
Chen SL, Fang WW, Ye F, et al. Effect on left ventricular function of intracoronary transplantation of autologous bone marrow mesenchymal stem cell in patients with acute infarction. Am J Cardiol. 2004;94:92–5.
pubmed: 15219514
Hare JM, Traverse JH, Henry TD, et al. A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. J Am Coll Cardiol. 2009;54:2277–86.
pubmed: 19958962
pmcid: 3580848
Kim SH, Cho JH, Lee YH, et al. improvement in left ventricular function with intracoronary mesenchymal stem cell therapy in a patient with anterior wall ST-segment elevation myocardial infarction. Cardiovasc Drugs Ther. 2018;32:329–38.
pubmed: 29956042
pmcid: 6133167
Schächinger V, Assmus B, Britten MB. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction: final one-year results of the TOPCARE-AMI trial. J Am Coll Cardiol. 2004;44:1690–9.
pubmed: 15489105
Schächinger V, Erbs S, Elsasser A, et al. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med. 2006;355:1210–21.
pubmed: 16990384
Assmus B, Leistner DM, Schächinger V, et al. Long-term clinical outcome after intracoronary application of bone marrow-derived mononuclear cells for acute myocardial infarction: migratory capacity of administered cells determines event-free survival. Eur Heart J. 2014;35:1275–83.
pubmed: 24569031
Janssens S, Dubois C, Bogaert J, et al. Autologous bone-marrow derived stem cell transfer in patients with ST-segment elevation myocardial infarction: double blind, randomized controlled trial. Lancet. 2006;367:113–21.
pubmed: 16413875
Duan F, Qi Z, Liu S, et al. Effectiveness of bone marrow mononuclear cells delivered through a graft vessel for patients with previous myocardial infarction and chronic heart failure: an echocardiographic study of left ventricular remodeling. Med Ultrason. 2015;17:160–6.
pubmed: 26052565
Wöhrle J, von Scheidt F, Schauwecker P, et al. Impact of cell number and microvascular obstruction in patients with bone-marrow derived cell therapy: final results from the randomized, double-blind, placebo controlled intracoronary stem cell therapy in patients with acute myocardial infarction (SCAMI) trial. Clin Res Cardiol. 2013;102:765–70.
pubmed: 23896972
Quyyumi AA, Vasquez A, Kereiakes DJ, et al. PreSERVE-AMI: A randomized, double-blind, placebo-controlled clinical trial of intracoronary administration of autologous CD34+ cells in patients with left ventricular dysfunction post STEMI. Circ Res. 2017;120:324–31.
pubmed: 27821724
Wollert KC, Meyer GP, Müller-Ehmsen J, et al. Intracoronary autologous bone marrow cell transfer after myocardial infarction: the BOOST-2 randomised placebo-controlled clinical trial. Eur Heart J. 2017;38:2936–43.
pubmed: 28431003
Hirsch A, Nijveldt R, van der Vleuten PA, et al. Intracoronary infusion of autologous mononuclear bone marrow cells in patients with acute myocardial infarction treated with primary PCI: Pilot study of the multicenter HEBE trial. Catheter Cardiovasc Interv. 2008;71:273–81.
pubmed: 18288734
Tendera M, Wojakowski W, Ruzyłło W, et al. Intracoronary infusion of bone marrow-derived selected CD34+CXCR4+ cells and non-selected mononuclear cells in patients with acute STEMI and reduced left ventricular ejection fraction: results of randomized, multicentre myocardial regeneration by intracoronary infusion of selected population of stem cells in acute myocardial infarction (REGENT) trial. Eur Heart J. 2009;30:1313–21.
pubmed: 19208649
Gyöngyösi M, Lang I, Dettke M, et al. Combined delivery approach of bone marrow mononuclear stem cells early and late after myocardial infarction:the MYSTAR prospective, randomized study. Nat Clin Pract Cardiovasc Med. 2009;6:70–81.
pubmed: 19002124
Sürder D, Schwitter J, Moccetti T, et al. Cell-based therapy for myocardial repair in patients with acute myocardial infarction: rationale and study design of the SWiss multicenter Intracoronary Stem cells Study in Acute Myocardial Infarction (SWISS-AMI). Am Heart J. 2010;160:58–64.
pubmed: 20598973
Lunde K, Solheim S, Aakhus S, et al. Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction. N Engl J Med. 2006;355:1199–209.
pubmed: 16990383
Lunde K, Solheim S, Aakhus S, et al. Exercise capacity and quality of life after intracoronary injection of autologous mononuclear bone marrow cells in acute myocardial infarction: results from the Autologous Stem cell Transplantation in Acute Myocardial Infarction (ASTAMI) randomized controlled trial. Am Heart J. 2007;154(710):e1-8.
Fernández-Avilés F, Sanz-Ruiz R, Bogaert J, et al. Safety and efficacy of intracoronary infusion of allogeneic human cardiac stem cells in patients with ST-segment elevation myocardial infarction and left ventricular dysfunction. Circ Res. 2018;123:579–89.
pubmed: 29921651
Nicolau JC, Furtado RHM, Silva SA, et al. Stem-cell therapy in ST-segment elevation myocardial infarction with reduced ejection fraction: A multicenter, double-blind randomized trial. Clin Cardiol. 2018;41:392–9.
pubmed: 29569254
pmcid: 6489870
Mathur A, Fernández-Avilés F, Bartunek J, et al. The effect of intracoronary infusion of bone marrow-derived mononuclear cells on all-cause mortality in acute myocardial infarction: the BAMI trial. Eur Heart J. 2020;41:3702–10.
pubmed: 32860406
pmcid: 7666866
Traverse JH, Henry TD, Pepine CJ, et al. Effect of the use and timing of bone marrow mononuclear cell delivery on left ventricular function after acute myocardial infarction: the TIME randomized trial. JAMA. 2012;308:2380–9.
pubmed: 23129008
pmcid: 3652242
Mathiasen AB, Qayyum AA, Jørgensen E, et al. Bone marrow-derived mesenchymal stromal cell treatment in patients with ischaemic heart failure: final 4-year follow-up of the MSC-HF trial. Eur J Heart Fail. 2020;22:884–92.
pubmed: 31863561
Bolli R, Kahlon A. Time to end the war on cell therapy. Eur J Heart Fail. 2020;22:893–989.
pubmed: 32100951
Hastings CL, Roche ET, Ruiz-Hernandez E, et al. Drug and cell delivery for cardiac regeneration. Adv Drug Deliv Rev. 2015;84:85–106.
pubmed: 25172834
Murry CE, Soonpaa MH, Reinecke H, et al. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature. 2004;428:664–8.
pubmed: 15034593
Kang HJ, Kang WS, Hong MH, et al. Involvement of miR-34c in high glucose-insulted mesenchymal stem cells leads to inefficient therapeutic effect on myocardial infarction. Cell Signal. 2015;27:2241–51.
pubmed: 26232617
Oswald J, Boxberger S, Jorgensen B, et al. Mesenchymal stem cells can be differentiated into endothelial cells in vitro. Stem Cells. 2004;22:377–434.
pubmed: 15153614
Toma C, Pittenger MF, Cahill KS, et al. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation. 2002;105:93–8.
pubmed: 11772882
Tang YL, Zhao Q, Zhang YC, et al. Autologous mesenchymal stem cell transplantation induce VEGF and neovascularization in ischemic myocardium. Regul Pept. 2004;117:3–10.
pubmed: 14687695
Pittenger MF, Martin BJ. Mesenchymal stem cells and their potential as cardiac therapeutics. Circ Res. 2004;95:9–20.
pubmed: 15242981
Hatzistergos KE, Quevedo H, Oskouei BN, et al. Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation. Circ Res. 2010;107:913–22.
pubmed: 20671238
pmcid: 3408082
Bolli R. Cell therapy for acute myocardial infarction: requiescat in pace. Eur Heart J. 2020;41:3711–4.
pubmed: 33099279