Developmental mechanisms of adrenal cortex formation and their links with adult progenitor populations.
Adrenal
Development
Stem cells
Journal
Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844
Informations de publication
Date de publication:
15 03 2021
15 03 2021
Historique:
received:
06
10
2020
revised:
15
12
2020
accepted:
13
01
2021
pubmed:
24
1
2021
medline:
24
9
2021
entrez:
23
1
2021
Statut:
ppublish
Résumé
The adrenal cortex is the main steroid producing organ of the human body. Studies on adrenal tissue renewal have been neglected for many years, but recent intensified research has seen tremendous progress in our understanding of the formation and homeostasis of this organ. However, cell turnover of the adrenal cortex appears to be complex and several cell populations have been identified that can differentiate into steroidogenic cells and contribute to adrenal cortex renewal. The purpose of this review is to provide an overview of how the adrenal cortex develops and how stem cell populations relate to its developmental progenitors. Finally, we will summarize present and future approaches to harvest the potential of progenitor/stem cells for future cell replacement therapies.
Identifiants
pubmed: 33484742
pii: S0303-7207(21)00016-2
doi: 10.1016/j.mce.2021.111172
pii:
doi:
Substances chimiques
Steroids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111172Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.