Ankyrins and neurological disease.
Journal
Current opinion in neurobiology
ISSN: 1873-6882
Titre abrégé: Curr Opin Neurobiol
Pays: England
ID NLM: 9111376
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
15
12
2020
revised:
06
01
2021
accepted:
08
01
2021
pubmed:
24
1
2021
medline:
14
9
2021
entrez:
23
1
2021
Statut:
ppublish
Résumé
Ankyrins are scaffolding proteins widely expressed throughout the nervous system. Ankyrins recruit diverse membrane proteins, including ion channels and cell adhesion molecules, into specialized subcellular membrane domains. These domains are stabilized by ankyrins interacting with the spectrin cytoskeleton. Ankyrin genes are highly associated with a number of neurological disorders, including Alzheimer's disease, schizophrenia, autism spectrum disorders, and bipolar disorder. Here, we discuss ankyrin function and their role in neurological disease. We propose mutations in ankyrins contribute to disease through two primary mechanisms: 1) altered neuronal excitability by disrupting ion channel clustering at key excitable domains, and 2) altered neuronal connectivity via impaired stabilization of membrane proteins.
Identifiants
pubmed: 33485190
pii: S0959-4388(21)00004-0
doi: 10.1016/j.conb.2021.01.002
pmc: PMC8289910
mid: NIHMS1663960
pii:
doi:
Substances chimiques
Ankyrins
0
Spectrin
12634-43-4
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
51-57Subventions
Organisme : NINDS NIH HHS
ID : F31 NS100300
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS044916
Pays : United States
Organisme : NINDS NIH HHS
ID : R37 NS044916
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
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