Macromolecular aging: ATP hydrolysis-driven functional and structural changes in Escherichia coli RecQ helicase.
ATP hydrolysis
Fatigued enzyme
Macromolecular aging
Non-fatigued enzyme
RecQ helicase
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
20 Jan 2021
20 Jan 2021
Historique:
received:
28
12
2020
accepted:
06
01
2021
pubmed:
24
1
2021
medline:
24
1
2021
entrez:
23
1
2021
Statut:
aheadofprint
Résumé
Aging has been considered a phenomenon that can be only applied to cells or organisms. Here, we show that RecQ helicase from E. coli displays an aging phenomenon: this macromolecular motor loses its structure and function after hydrolyzing a certain number of ATP molecules. The aging process was only triggered by repeated catalytic cycles. These observations lead to a new concept: macromolecule aging.
Identifiants
pubmed: 33485211
pii: S0006-291X(21)00055-3
doi: 10.1016/j.bbrc.2021.01.020
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
29-33Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no conflict of interest.