Systemic diseases and the cornea.

Addison's disease Aniridia Autoimmune disease Corneal deposit disorder Diabetic cornea Ehlers-Danlos syndrome Genetic corneal disease Graves' disease Herpes Immunobullous disease Inflammation Keratoconjunctivitis Marfan syndrome Pseudomonas aeruginosa SARS-CoV-2 Sjögren's syndrome Syphilis Tuberculosis Zoster

Journal

Experimental eye research
ISSN: 1096-0007
Titre abrégé: Exp Eye Res
Pays: England
ID NLM: 0370707

Informations de publication

Date de publication:
03 2021
Historique:
received: 15 12 2020
revised: 11 01 2021
accepted: 12 01 2021
pubmed: 25 1 2021
medline: 17 3 2021
entrez: 24 1 2021
Statut: ppublish

Résumé

There is a number of systemic diseases affecting the cornea. These include endocrine disorders (diabetes, Graves' disease, Addison's disease, hyperparathyroidism), infections with viruses (SARS-CoV-2, herpes simplex, varicella zoster, HTLV-1, Epstein-Barr virus) and bacteria (tuberculosis, syphilis and Pseudomonas aeruginosa), autoimmune and inflammatory diseases (rheumatoid arthritis, Sjögren's syndrome, lupus erythematosus, gout, atopic and vernal keratoconjunctivitis, multiple sclerosis, granulomatosis with polyangiitis, sarcoidosis, Cogan's syndrome, immunobullous diseases), corneal deposit disorders (Wilson's disease, cystinosis, Fabry disease, Meretoja's syndrome, mucopolysaccharidosis, hyperlipoproteinemia), and genetic disorders (aniridia, Ehlers-Danlos syndromes, Marfan syndrome). Corneal manifestations often provide an insight to underlying systemic diseases and can act as the first indicator of an undiagnosed systemic condition. Routine eye exams can bring attention to potentially life-threatening illnesses. In this review, we provide a fairly detailed overview of the pathologic changes in the cornea described in various systemic diseases and also discuss underlying molecular mechanisms, as well as current and emerging treatments.

Identifiants

pubmed: 33485845
pii: S0014-4835(21)00020-8
doi: 10.1016/j.exer.2021.108455
pmc: PMC7946758
mid: NIHMS1666810
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

108455

Subventions

Organisme : NEI NIH HHS
ID : R01 EY026964
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY013615
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY013431
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY029160
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY025377
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY024649
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY031377
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY026944
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY029829
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY027381
Pays : United States

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

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Auteurs

Ruchi Shah (R)

Eye Program, Board of Governors Regenerative Medicine Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA. Electronic address: Ruchi.Shah@cshs.org.

Cynthia Amador (C)

Eye Program, Board of Governors Regenerative Medicine Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Kati Tormanen (K)

Center for Neurobiology and Vaccine Development, Department of Surgery, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Sean Ghiam (S)

Sackler School of Medicine, New York State/American Program of Tel Aviv University, Tel Aviv, Israel.

Mehrnoosh Saghizadeh (M)

Eye Program, Board of Governors Regenerative Medicine Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Departments of Molecular and Medical Pharmacology, Medicine, and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

Vaithi Arumugaswami (V)

Departments of Molecular and Medical Pharmacology, Medicine, and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.

Ashok Kumar (A)

Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University, Detroit, MI, USA.

Andrei A Kramerov (AA)

Eye Program, Board of Governors Regenerative Medicine Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Alexander V Ljubimov (AV)

Eye Program, Board of Governors Regenerative Medicine Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Departments of Molecular and Medical Pharmacology, Medicine, and Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. Electronic address: ljubimov@cshs.org.

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