Accrual of functional redundancy along the lifespan and its effects on cognition.
Aging
Brain reserve
Executive function
Network analysis
Redundancy
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
01 04 2021
01 04 2021
Historique:
received:
08
12
2020
revised:
04
01
2021
accepted:
05
01
2021
pubmed:
25
1
2021
medline:
14
10
2021
entrez:
24
1
2021
Statut:
ppublish
Résumé
Despite the necessity to understand how the brain endures the initial stages of age-associated cognitive decline, no brain mechanism has been quantitatively specified to date. The brain may withstand the effects of cognitive aging through redundancy, a design feature in engineered and biological systems, which entails the presence of substitute elements to protect it against failure. Here, we investigated the relationship between functional network redundancy and age over the human lifespan and their interaction with cognition, analyzing resting-state functional MRI images and cognitive measures from 579 subjects. Network-wide redundancy was significantly associated with age, showing a stronger link with age than other major topological measures, presenting a pattern of accumulation followed by old-age decline. Critically, redundancy significantly mediated the association between age and executive function, with lower anti-correlation between age and cognition in subjects with high redundancy. The results suggest that functional redundancy accrues throughout the lifespan, mitigating the effects of age on cognition.
Identifiants
pubmed: 33486125
pii: S1053-8119(21)00014-8
doi: 10.1016/j.neuroimage.2021.117737
pmc: PMC8022200
mid: NIHMS1687517
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
117737Subventions
Organisme : NIA NIH HHS
ID : R01 AG062590
Pays : United States
Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no competing financial interests.
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