Update on Eosinophil Interaction with Mast Cells: The Allergic Effector Unit.
Animals
Cell Communication
/ immunology
Cell Culture Techniques
/ methods
Chemokines
/ metabolism
Coculture Techniques
/ methods
Cytokines
/ metabolism
Eosinophils
/ cytology
Female
Humans
Hypersensitivity
/ metabolism
Inflammation
/ metabolism
Male
Mast Cells
/ cytology
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Allergic effector unit
BMEos
BMMCs
Co-culture
Mast cell-eosinophil interactions
Murine AEU
Journal
Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969
Informations de publication
Date de publication:
2021
2021
Historique:
entrez:
24
1
2021
pubmed:
25
1
2021
medline:
31
3
2021
Statut:
ppublish
Résumé
Mast cells and eosinophils are the key effector cells of allergy [1]. In general, allergic reactions are composed of two phases, namely an early phase and a late phase, and after that resolution occurs. If the allergic reactions fail to resolve after the late phase, allergic inflammation (AI) can evolve into a chronic phase mainly involving mast cells and eosinophils that abundantly coexist in the inflamed tissue in the late and chronic phases and cross-talk in a bidirectional manner. We defined these bidirectional interactions between MCs and Eos, as the "allergic effector unit." This cross talk is mediated by both physical cell-cell contacts through cell surface receptors such as CD48, 2B4, and respective ligands and through released mediators such as various specific granular mediators, arachidonic acid metabolites, cytokines, and chemokines [2, 3]. The allergic effector unit can be studied in vitro in a customized co-culture system using mast cells and eosinophils derived from either mouse or human sources.
Identifiants
pubmed: 33486740
doi: 10.1007/978-1-0716-1095-4_18
doi:
Substances chimiques
Chemokines
0
Cytokines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
221-242Références
Minai-Fleminger Y, Levi-Schaffer F (2009) Mast cells and eosinophils: the two key effector cells in allergic inflammation. Inflamm Res 58:631–638. https://doi.org/10.1007/s00011-009-0042-6
doi: 10.1007/s00011-009-0042-6
Elishmereni M, Alenius HT, Bradding P et al (2011) Physical interactions between mast cells and eosinophils: a novel mechanism enhancing eosinophil survival in vitro. Allergy 66:376–385. https://doi.org/10.1111/j.1398-9995.2010.02494.x
doi: 10.1111/j.1398-9995.2010.02494.x
Minai-Fleminger Y, Elishmereni M, Vita F et al (2010) Ultrastructural evidence for human mast cell-eosinophil interactions in vitro. Cell Tissue Res 341:405–415
doi: 10.1007/s00441-010-1010-8
Galli SJ, Grimbaldeston M, Tsai M (2008) Immunomodulatory mast cells: negative, as well as positive, regulators of immunity. Nat Rev Immunol 8:478–486. https://doi.org/10.1038/nri2327
doi: 10.1038/nri2327
Bachelet I, Levi-Schaffer F, Mekori YA (2006) Mast cells: not only in allergy. Immunol Allergy Clin N Am 26:407–425. https://doi.org/10.1016/j.iac.2006.05.007
doi: 10.1016/j.iac.2006.05.007
Bischoff SC (2007) Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data. Nat Rev Immunol 7:93–104. https://doi.org/10.1038/nri2018
doi: 10.1038/nri2018
Puxeddu I, Piliponsky AM, Bachelet I, Levi-Schaffer F (2003) Mast cells in allergy and beyond. Int J Biochem Cell Biol 35:1601–1607
doi: 10.1016/S1357-2725(03)00208-5
Theoharides TC, Kalogeromitros D (2006) The critical role of mast cells in allergy and inflammation. Ann N Y Acad Sci 1088:78–99. https://doi.org/10.1196/annals.1366.025
doi: 10.1196/annals.1366.025
Galli SJ, Tsai M, Piliponsky AM (2008) The development of allergic inflammation. Nature 454:445–454. https://doi.org/10.1038/nature07204
doi: 10.1038/nature07204
Harvima IT, Levi-Schaffer F, Draber P et al (2014) Molecular targets on mast cells and basophils for novel therapies. J Allergy Clin Immunol 134:530–544. https://doi.org/10.1016/j.jaci.2014.03.007
doi: 10.1016/j.jaci.2014.03.007
Dahlin JS, Malinovschi A, Ohrvik H et al (2016) Lin- CD34hi CD117int/hi FcepsilonRI+ cells in human blood constitute a rare population of mast cell progenitors. Blood 127:383–391. https://doi.org/10.1182/blood-2015-06-650648
doi: 10.1182/blood-2015-06-650648
Tatemoto K, Nozaki Y, Tsuda R et al (2006) Immunoglobulin E-independent activation of mast cell is mediated by Mrg receptors. Biochem Biophys Res Commun 349:1322–1328. https://doi.org/10.1016/j.bbrc.2006.08.177
doi: 10.1016/j.bbrc.2006.08.177
O'Sullivan JA, Carroll DJ, Cao Y et al (2018) Leveraging Siglec-8 endocytic mechanisms to kill human eosinophils and malignant mast cells. J Allergy Clin Immunol 141(1774-1785):e1777. https://doi.org/10.1016/j.jaci.2017.06.028
doi: 10.1016/j.jaci.2017.06.028
Mizrahi S, Gibbs BF, Karra L et al (2014) Siglec-7 is an inhibitory receptor on human mast cells and basophils. J Allergy Clin Immunol 134:230–233. https://doi.org/10.1016/j.jaci.2014.03.031
doi: 10.1016/j.jaci.2014.03.031
Bachelet I, Munitz A, Berent-Maoz B et al (2008) Suppression of normal and malignant kit signaling by a bispecific antibody linking kit with CD300a. J Immunol 180:6064–6069. https://doi.org/10.4049/jimmunol.180.9.6064
doi: 10.4049/jimmunol.180.9.6064
Bachelet I, Munitz A, Levi-Schaffer F (2006) Abrogation of allergic reactions by a bispecific antibody fragment linking IgE to CD300a. J Allergy Clin Immunol 117:1314–1320. https://doi.org/10.1016/j.jaci.2006.04.031
doi: 10.1016/j.jaci.2006.04.031
Bachelet I, Munitz A, Moretta A, Moretta L, Levi-Schaffer F (2005) The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells. J Immunol 175:7989–7995. https://doi.org/10.4049/jimmunol.175.12.7989
doi: 10.4049/jimmunol.175.12.7989
Gangwar RS, Landolina N, Arpinati L, Levi-Schaffer F (2017) Mast cell and eosinophil surface receptors as targets for anti-allergic therapy. Pharmacol Ther 170:37–63. https://doi.org/10.1016/j.pharmthera.2016.10.010
doi: 10.1016/j.pharmthera.2016.10.010
Kita H (2013) Eosinophils: multifunctional and distinctive properties. Int Arch Allergy Immunoly 161(Suppl 2):3–9. https://doi.org/10.1159/000350662
doi: 10.1159/000350662
Fulkerson PC, Rothenberg ME (2013) Targeting eosinophils in allergy, inflammation and beyond. Nat Rev Drug Discov 12:117–129. https://doi.org/10.1038/nrd3838
doi: 10.1038/nrd3838
Gleich GJ, Adolphson CR (1986) The eosinophilic leukocyte: structure and function. Adv Immunol 39:177–253
doi: 10.1016/S0065-2776(08)60351-X
Robida PA, Puzzovio PG, Pahima H et al (2018) Human eosinophils and mast cells: birds of a feather flock together. Immunol Rev 282:151–167. https://doi.org/10.1111/imr.12638
doi: 10.1111/imr.12638
Rothenberg ME, Hogan SP (2006) The eosinophil. Annu Rev Immunol 24:147–174. https://doi.org/10.1146/annurev.immunol.24.021605.090720
doi: 10.1146/annurev.immunol.24.021605.090720
Elishmereni M, Bachelet I, Nissim Ben-Efraim AH et al (2013) Interacting mast cells and eosinophils acquire an enhanced activation state in vitro. Allergy 68:171–179. https://doi.org/10.1111/all.12059
doi: 10.1111/all.12059
Shakoory B, Fitzgerald SM, Lee SA et al (2004) The role of human mast cell-derived cytokines in eosinophil biology. J Interf Cytokine Res 24:271–281. https://doi.org/10.1089/107999004323065057
doi: 10.1089/107999004323065057
Bachelet I, Munitz A, Mankutad D, Levi-Schaffer F (2006) Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J BiolChem 281:27190–27196
Munitz A, Bachelet I, Fraenkel S et al (2005) 2B4 (CD244) is expressed and functional on human eosinophils. J Immunol 174:110–118
doi: 10.4049/jimmunol.174.1.110
Blank U, Rivera J (2006) Assays for regulated exocytosis of mast cell granules. Curr Protoc Cell Biol Unit 15:11. Chapter 15. https://doi.org/10.1002/0471143030.cb1511s32
doi: 10.1002/0471143030.cb1511s32
Berent-Maoz B, Gur C, Vita F et al (2011) Influence of FAS on murine mast cell maturation. Ann Allergy Asthma Immunol 106:239–244. https://doi.org/10.1016/j.anai.2010.12.001
doi: 10.1016/j.anai.2010.12.001
Jensen BM, Swindle EJ, Iwaki S et al (2006) Generation, isolation, and maintenance of rodent mast cells and mast cell lines. Curr Protoc Immunol Unit 3:23. Chapter 3. https://doi.org/10.1002/0471142735.im0323s74
doi: 10.1002/0471142735.im0323s74
Dyer KD, Moser JM, Czapiga M et al (2008) Functionally competent eosinophils differentiated ex vivo in high purity from normal mouse bone marrow. J Immunol 181:4004–4009
doi: 10.4049/jimmunol.181.6.4004
Levi-Schaffer F, Austen KF, Gravallese PM et al (1986) Coculture of interleukin 3-dependent mouse mast cells with fibroblasts results in a phenotypic change of the mast cells. Proc Natl Acad Sci U S A 83:6485–6488. https://doi.org/10.1073/pnas.83.17.6485
doi: 10.1073/pnas.83.17.6485
Kawakami T, Galli SJ (2002) Regulation of mast-cell and basophil function and survival by IgE. Nat Rev Immunol 2:773–786. https://doi.org/10.1038/nri914
doi: 10.1038/nri914
Galli SJ, Kalesnikoff J, Grimbaldeston MA et al (2005) Mast cells as "tunable" effector and immunoregulatory cells: recent advances. Ann Rev Immunol 23:749–786
doi: 10.1146/annurev.immunol.21.120601.141025
Kalesnikoff J, Galli SJ (2008) New developments in mast cell biology. Nat Immunol 9:1215–1223
doi: 10.1038/ni.f.216
Bloemen K, Verstraelen S, Van Den Heuvel R et al (2007) The allergic cascade: review of the most important molecules in the asthmatic lung. Immunol Lett 113:6–18
doi: 10.1016/j.imlet.2007.07.010
Prussin C, Metcalfe DD (2006) 5. IgE, mast cells, basophils, and eosinophils. J Allergy Clin Immunol 117(2 Suppl Mini-Primer):S450–S456
doi: 10.1016/j.jaci.2005.11.016
Minai-Fleminger Y, Gangwar RS, Migalovich-Sheikhet H et al (2014) The CD48 receptor mediates Staphylococcus aureus human and murine eosinophil activation. Clin Exp Allergy 44:1335–1346. https://doi.org/10.1111/cea.12422
doi: 10.1111/cea.12422
Karra L, Gangwar RS, Puzzovio PG et al (2019) CD300a expression is modulated in atopic dermatitis and could influence the inflammatory response. Allergy 74:1377–1380. https://doi.org/10.1111/all.13724
doi: 10.1111/all.13724
Akula S, Paivandy A, Fu Z et al (2020) Quantitative in-depth analysis of the mouse mast cell transcriptome reveals organ-specific mast cell heterogeneity. Cell 9(1):211. https://doi.org/10.3390/cells9010211
doi: 10.3390/cells9010211
Shimanaka Y, Kono N, Taketomi Y et al (2017) Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation. Nat Med 23:1287–1297. https://doi.org/10.1038/nm.4417
doi: 10.1038/nm.4417
Nath AP, Ritchie SC, Byars SG et al (2017) An interaction map of circulating metabolites, immune gene networks, and their genetic regulation. Genome Biol 18:146. https://doi.org/10.1186/s13059-017-1279-y
doi: 10.1186/s13059-017-1279-y
Pretlow TP, Wilk AI, Davis LA et al (1988) Comparison of different methods for the purification of eosinophils from human peripheral blood. Anal Biochem 175:334–341
doi: 10.1016/0003-2697(88)90397-1
Hansel TT, De Vries IJ, Iff T et al (1991) An improved immunomagnetic procedure for the isolation of highly purified human blood eosinophils. J Immunol Methods 145:105–110
doi: 10.1016/0022-1759(91)90315-7
Saito H, Ebisawa M, Sakaguchi N et al (1995) Characterization of cord-blood-derived human mast cells cultured in the presence of steel factor and interleukin-6. Int Arch Allergy Immunol 107:63–65
doi: 10.1159/000236932
Mitsui H, Furitsu T, Dvorak AM et al (1993) Development of human mast cells from umbilical cord blood cells by recombinant human and murine c-kit ligand. Proc Natl Acad Sci U S A 90:735–739. https://doi.org/10.1073/pnas.90.2.735
doi: 10.1073/pnas.90.2.735
Elishmereni M, Fyhrquist N, Singh Gangwar R et al (2014) Complex 2B4 regulation of mast cells and eosinophils in murine allergic inflammation. J Invest Dermatol 134:2928–2937. https://doi.org/10.1038/jid.2014.280
doi: 10.1038/jid.2014.280
Yurt RW, Leid RW Jr, Austen KF (1977) Native heparin from rat peritoneal mast cells. J Biol Chem 252:518–521
doi: 10.1016/S0021-9258(17)32747-3
Kovarova M (2013) Isolation and characterization of mast cells in mouse models of allergic diseases. Methods Mol Biol 1032:109–119. https://doi.org/10.1007/978-1-62703-496-8_8
doi: 10.1007/978-1-62703-496-8_8
Yamada N, Matsushima H, Tagaya Y et al (2003) Generation of a large number of connective tissue type mast cells by culture of murine fetal skin cells. J Invest Dermatol 121:1425–1432. https://doi.org/10.1046/j.1523-1747.2003.12613.x
doi: 10.1046/j.1523-1747.2003.12613.x
Matsue H, Kambe N, Shimada S (2009) Murine fetal skin-derived cultured mast cells: a useful tool for discovering functions of skin mast cells. J Invest Dermatol 129:1120–1125. https://doi.org/10.1038/jid.2009.44
doi: 10.1038/jid.2009.44
Konno S, Adachi M, Asano K et al (1993) Inhibitory effect of interferon-beta on mouse spleen-derived mast cells. Mediat Inflamm 2:243–246. https://doi.org/10.1155/S096293519300033X
doi: 10.1155/S096293519300033X
Levi-Schaffer F, Dayton ET, Austen KF et al (1987) Mouse bone marrow-derived mast cells cocultured with fibroblasts. Morphology and stimulation-induced release of histamine, leukotriene B4, leukotriene C4, and prostaglandin D2. J Immunol 139:3431–3441
Nilsson G, Blom T, Kusche-Gullberg M et al (1994) Phenotypic characterization of the human mast-cell line HMC-1. Scand J Immunol 39:489–498
doi: 10.1111/j.1365-3083.1994.tb03404.x
Kirshenbaum AS, Akin C, Wu Y et al (2003) Characterization of novel stem cell factor responsive human mast cell lines LAD 1 and 2 established from a patient with mast cell sarcoma/leukemia; activation following aggregation of FcepsilonRI or FcgammaRI. Leuk Res 27:677–682
doi: 10.1016/S0145-2126(02)00343-0
Rottem M, Okada T, Goff JP et al (1994) Mast cells cultured from the peripheral blood of normal donors and patients with mastocytosis originate from a CD34+/Fc epsilon RI-cell population. Blood 84:2489–2496
doi: 10.1182/blood.V84.8.2489.2489
Salari H, Takei F, Miller R et al (1987) Novel technique for isolation of human lung mast cells. J Immunol Methods 100(1-2):91–97
doi: 10.1016/0022-1759(87)90176-1
Church MK, Clough GF (1999) Human skin mast cells: in vitro and in vivo studies. Ann Allergy Asthma Immunol 83:471–475. https://doi.org/10.1016/S1081-1206(10)62853-0
doi: 10.1016/S1081-1206(10)62853-0
Fox CC, Dvorak AM, Peters SP et al (1985) Isolation and characterization of human intestinal mucosal mast cells. J Immunol 135:483–491
Sperr WR, Bankl HC, Mundigler G et al (1994) The human cardiac mast cell: localization, isolation, phenotype, and functional characterization. Blood 84:3876–3884
doi: 10.1182/blood.V84.11.3876.bloodjournal84113876
Massey WA, Guo CB, Dvorak AM et al (1991) Human uterine mast cells. Isolation, purification, characterization, ultrastructure, and pharmacology. J Immunol 147:1621–1627
Finotto S, Dolovich J, Denburg JA et al (1994) Functional heterogeneity of mast cells isolated from different microenvironments within nasal polyp tissue. Clin Exp Immunol 95:343–350
doi: 10.1111/j.1365-2249.1994.tb06535.x
Reichman H, Rozenberg P, Munitz A (2017) Mouse eosinophils: identification, isolation, and functional analysis. Curr Protoc Immunol 119:14.43.1–14.43.22. https://doi.org/10.1002/cpim.35
doi: 10.1002/cpim.35
Cypcar D, Sorkness R, Sedgwick J et al (1996) Rat eosinophils: isolation and characterization of superoxide production. J Leuk Biol 60:101–105
doi: 10.1002/jlb.60.1.101
Wong TW, Jelinek DF (2013) Purification of functional eosinophils from human bone marrow. J Immunol Methods 387:130–139. https://doi.org/10.1016/j.jim.2012.10.006
doi: 10.1016/j.jim.2012.10.006
Kajiwara N, Sasaki T, Bradding P et al (2010) Activation of human mast cells through the platelet-activating factor receptor. J Allergy Clin Immunol 125(1137–1145):e1136. https://doi.org/10.1016/j.jaci.2010.01.056
doi: 10.1016/j.jaci.2010.01.056