Leptin levels in patients with Parkinson's disease: A systematic review and meta-analysis.

Female Humans Inflammation Leptin Male Parkinson Disease
Leptin Meta-analysis Parkinson's disease Systematic review

Journal

Clinical nutrition ESPEN
ISSN: 2405-4577
Titre abrégé: Clin Nutr ESPEN
Pays: England
ID NLM: 101654592

Informations de publication

Date de publication:
02 2021
Historique:
received: 22 05 2020
revised: 19 09 2020
accepted: 01 11 2020
entrez: 25 1 2021
pubmed: 26 1 2021
medline: 25 9 2021
Statut: ppublish

Résumé

The exact mechanism of Parkinson's disease (PD) is not fully understood yet, but it is suggested that inflammation is one of its contributing factors. Among several inflammatory factors, adipokines, especially leptin may have a great role in this mechanism; since it is not only causing inflammation, but it can also play other roles in the body that may contribute to the symptoms described for PD. Regarding the contradictions in the association of serum leptin levels with Parkinson's disease, a systematic review and meta-analysis was performed to have a more accurate estimation of this relationship. Published literature was obtained by searching PubMed, Embase, Cochrane Library, Scopus, Ovid, ProQuest and Google Scholar. Random-effect model analysis was used to calculate pooled standard mean difference (SMD) with 95% confidence interval (CI). Heterogeneity was tested with the heterogeneity statistic Q and quantified using I Six studies including a total number of 198 PD patients and 182 controls were finally included in the meta-analysis. Serum leptin levels in PD patients were non-significantly lower than those in control group (SMD = -0.40 ng/ml, 95% CI -2.33-1.53). Subgroup analyses revealed that serum leptin levels of PD patients and controls in either females or males didn't show any significant difference. This meta-analysis revealed that leptin level doesn't show any significant difference between PD patients and healthy controls, even when taking the participants' gender into consideration.

Sections du résumé

BACKGROUND AND AIMS
The exact mechanism of Parkinson's disease (PD) is not fully understood yet, but it is suggested that inflammation is one of its contributing factors. Among several inflammatory factors, adipokines, especially leptin may have a great role in this mechanism; since it is not only causing inflammation, but it can also play other roles in the body that may contribute to the symptoms described for PD. Regarding the contradictions in the association of serum leptin levels with Parkinson's disease, a systematic review and meta-analysis was performed to have a more accurate estimation of this relationship.
METHODS
Published literature was obtained by searching PubMed, Embase, Cochrane Library, Scopus, Ovid, ProQuest and Google Scholar. Random-effect model analysis was used to calculate pooled standard mean difference (SMD) with 95% confidence interval (CI). Heterogeneity was tested with the heterogeneity statistic Q and quantified using I
RESULTS
Six studies including a total number of 198 PD patients and 182 controls were finally included in the meta-analysis. Serum leptin levels in PD patients were non-significantly lower than those in control group (SMD = -0.40 ng/ml, 95% CI -2.33-1.53). Subgroup analyses revealed that serum leptin levels of PD patients and controls in either females or males didn't show any significant difference.
CONCLUSIONS
This meta-analysis revealed that leptin level doesn't show any significant difference between PD patients and healthy controls, even when taking the participants' gender into consideration.

Identifiants

DOI: 10.1016/j.clnesp.2020.11.001 PMID: 33487251
pubmed: 33487251
pii: S2405-4577(20)31076-7
doi: 10.1016/j.clnesp.2020.11.001
pii:
doi:

Substances chimiques

Leptin 0

Types de publication

Journal Article Meta-Analysis Research Support, Non-U.S. Gov't Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

104-109

Informations de copyright

Copyright © 2020 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no conflicts of interest.

Auteurs

Sama Rahnemayan (S)

Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

Mojgan Mirghafourvand (M)

Social Determinants of Health Research Center, Midwifery Department, Tabriz University of Medical Sciences, Tabriz, Iran.

Arezoo Fathalizadeh (A)

Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

Elnaz Faramarzi (E)

Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Anita Reyhanifard (A)

Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.

Ata Mahmoodpoor (A)

Anesthesiology and Critical Care Department, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Sarvin Sanaie (S)

Neurosciences Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: sarvin_so2000@yahoo.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Leptin levels in patients with Parkinson's...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Leptin levels in patients with Parkinson's...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Adipokines › Leptine › Leptin levels in patients with Parkinson's...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladie de Parkinson › Leptin levels in patients with Parkinson's...