Evaluation of Antihyperglycemic Effect of Extract of
Moringa stenopetala
alloxan monohydrate
diabetes
pancreatic β-cells
Journal
Diabetes, metabolic syndrome and obesity : targets and therapy
ISSN: 1178-7007
Titre abrégé: Diabetes Metab Syndr Obes
Pays: New Zealand
ID NLM: 101515585
Informations de publication
Date de publication:
2021
2021
Historique:
received:
17
09
2020
accepted:
04
12
2020
entrez:
25
1
2021
pubmed:
26
1
2021
medline:
26
1
2021
Statut:
epublish
Résumé
Diabetes is a serious metabolic disorder with complications that result in significant morbidity and mortality. Current drugs used for diabetes therapy are not free from side effects and do not restore normal glucose homeostasis. Therefore, the purpose of this study is to evaluate the antidiabetic effect of Thirty rats of weight 90-150 gram were distributed to five groups (n= 6). Then labelled as diabetic control (DC), normal control (NC), extract treated (MS 250 and 500mg/kg), and glibenclamide treated (GL 5mg/kg). The experimental rats were induced by intra-peritoneal injection of Alloxan monohydrate at a dose of 180 mg/kg after dissolving in normal saline. Clinical biochemistry such as AST, ALT, ALP, urea, creatinine, and cholesterol, blood glucose level, histopathological and preliminary phytochemical screening were evaluated. Phytochemical tests revealed the presence of different secondary metabolites. Alkaloid, flavonoid, tannin, saponin, phytosteroids, phenols and terpenoids. It is possible to conclude that oral administration of
Sections du résumé
BACKGROUND
BACKGROUND
Diabetes is a serious metabolic disorder with complications that result in significant morbidity and mortality. Current drugs used for diabetes therapy are not free from side effects and do not restore normal glucose homeostasis. Therefore, the purpose of this study is to evaluate the antidiabetic effect of
METHODS
METHODS
Thirty rats of weight 90-150 gram were distributed to five groups (n= 6). Then labelled as diabetic control (DC), normal control (NC), extract treated (MS 250 and 500mg/kg), and glibenclamide treated (GL 5mg/kg). The experimental rats were induced by intra-peritoneal injection of Alloxan monohydrate at a dose of 180 mg/kg after dissolving in normal saline. Clinical biochemistry such as AST, ALT, ALP, urea, creatinine, and cholesterol, blood glucose level, histopathological and preliminary phytochemical screening were evaluated.
RESULTS
RESULTS
Phytochemical tests revealed the presence of different secondary metabolites. Alkaloid, flavonoid, tannin, saponin, phytosteroids, phenols and terpenoids.
CONCLUSION
CONCLUSIONS
It is possible to conclude that oral administration of
Identifiants
pubmed: 33488106
doi: 10.2147/DMSO.S266794
pii: 266794
pmc: PMC7815076
doi:
Types de publication
Journal Article
Langues
eng
Pagination
185-192Informations de copyright
© 2021 Woldekidan et al.
Déclaration de conflit d'intérêts
The authors report no conflicts of interest for this work.
Références
BMJ Open. 2018 Aug 5;8(8):e020961
pubmed: 30082350
J Ethnopharmacol. 2000 Apr;70(1):9-15
pubmed: 10720784
Nutr Diabetes. 2019 Nov 4;9(1):33
pubmed: 31685799
Adv Pharmacol Sci. 2013;2013:716073
pubmed: 24416041
N Engl J Med. 1995 Aug 31;333(9):550-4
pubmed: 7623903
Electron Physician. 2016 Jan 15;8(1):1832-42
pubmed: 26955456
BMC Complement Altern Med. 2015 Jul 18;15:242
pubmed: 26187590
Phytother Res. 1999 Sep;13(6):538-9
pubmed: 10479771
Bull World Health Organ. 2014 Mar 1;92(3):204-13, 213A
pubmed: 24700980
N Engl J Med. 1995 Aug 31;333(9):541-9
pubmed: 7623902
Acta Diabetol. 2005 Jun;42(2):110-6
pubmed: 15944846
Phytother Res. 1999 Aug;13(5):442-4
pubmed: 10441791
BMC Complement Altern Med. 2012 May 16;12:63
pubmed: 22591682
Diabetes Res Clin Pract. 2011 Dec;94(3):311-21
pubmed: 22079683
Front Pharmacol. 2016 Apr 21;7:97
pubmed: 27148056
Toxicol Appl Pharmacol. 2005 Sep 1;207(2):160-9
pubmed: 16102567