Oxidative stress and male infertility.
antioxidants
lipid peroxidation
male infertility
oxidative stress
reactive oxygen species
Journal
Reproductive medicine and biology
ISSN: 1445-5781
Titre abrégé: Reprod Med Biol
Pays: Japan
ID NLM: 101213278
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
18
04
2020
revised:
19
09
2020
accepted:
28
09
2020
entrez:
25
1
2021
pubmed:
26
1
2021
medline:
26
1
2021
Statut:
epublish
Résumé
Between 30% and 80% of patients with male infertility produce excessive reactive oxygen species (ROS) in their ejaculate even though the cause of male infertility is unexplained in approximately half of cases. The strong connection between oxidative stress (OS) and male infertility has led recent investigators to propose the term "Male Oxidative Stress Infertility (MOSI)" to describe OS-associated male infertility. We searched the PubMed database for original and review articles to survey the effects of OS on male infertility, and then verified the effects and treatments. Seminal plasma contains many antioxidants that protect sperm from ROS, because low amounts of ROS are required in the physiological fertilization process. The production of excessive ROS causes OS which can lower fertility through lipid peroxidation, sperm DNA damage, and apoptosis. Several assays are available for evaluating OS, including the MiOXSYS® analyzer to measure oxidation-reduction potential. Several measures should be considered for minimizing OS and improving clinical outcomes. Accurately diagnosing patients with MOSI and identifying highly sensitive biomarkers through proteomics technology is vital for better clinical outcomes.
Sections du résumé
BACKGROUND
BACKGROUND
Between 30% and 80% of patients with male infertility produce excessive reactive oxygen species (ROS) in their ejaculate even though the cause of male infertility is unexplained in approximately half of cases. The strong connection between oxidative stress (OS) and male infertility has led recent investigators to propose the term "Male Oxidative Stress Infertility (MOSI)" to describe OS-associated male infertility.
METHODS
METHODS
We searched the PubMed database for original and review articles to survey the effects of OS on male infertility, and then verified the effects and treatments.
MAIN FINDINGS
RESULTS
Seminal plasma contains many antioxidants that protect sperm from ROS, because low amounts of ROS are required in the physiological fertilization process. The production of excessive ROS causes OS which can lower fertility through lipid peroxidation, sperm DNA damage, and apoptosis. Several assays are available for evaluating OS, including the MiOXSYS® analyzer to measure oxidation-reduction potential. Several measures should be considered for minimizing OS and improving clinical outcomes.
CONCLUSION
CONCLUSIONS
Accurately diagnosing patients with MOSI and identifying highly sensitive biomarkers through proteomics technology is vital for better clinical outcomes.
Identifiants
pubmed: 33488282
doi: 10.1002/rmb2.12353
pii: RMB212353
pmc: PMC7812476
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
41-52Informations de copyright
© 2020 The Authors. Reproductive Medicine and Biology published by John Wiley & Sons Australia, Ltd on behalf of Japan Society for Reproductive Medicine.
Déclaration de conflit d'intérêts
Conflicts of interest: The authors report no declarations of interest. Human/animal rights statements and informed consent: This article does not contain any studies with human and animal subjects performed by any of the authors. Approval by Ethics Committee: This research was supported by the Ethics Committee of Yokohama City University Medical Center.
Références
Contraception. 2002 Apr;65(4):305-11
pubmed: 12020784
Asian J Androl. 2017 May-Jun;19(3):350-354
pubmed: 26975485
Fertil Steril. 2014 Sep;102(3):705-10
pubmed: 24993799
Hum Reprod. 2005 Sep;20(9):2590-4
pubmed: 15932912
Int J Androl. 2008 Aug;31(4):403-7
pubmed: 17651404
Microcirculation. 2007 Jun-Jul;14(4-5):375-87
pubmed: 17613809
Reprod Sci. 2012 Aug;19(8):778-85
pubmed: 22534334
Andrologia. 2018 Aug;50(6):e13015
pubmed: 29656391
J Urol. 2008 Feb;179(2):639-42
pubmed: 18082213
Clin Chim Acta. 2005 Jun;356(1-2):199-203
pubmed: 15936318
Fertil Steril. 1995 Jun;63(6):1143-57
pubmed: 7750580
Andrologia. 2010 Oct;42(5):331-40
pubmed: 20860632
Reprod Biol Endocrinol. 2013 May 20;11:48
pubmed: 23688036
Hum Reprod. 2005 Aug;20(8):2261-70
pubmed: 15831507
Biochem Soc Symp. 1995;61:73-101
pubmed: 8660405
J Reprod Fertil. 1986 Nov;78(2):463-70
pubmed: 2433438
Urology. 1996 Dec;48(6):835-50
pubmed: 8973665
Fertil Steril. 1994 Aug;62(2):387-93
pubmed: 8034089
Reprod Biomed Online. 2017 Jan;34(1):48-57
pubmed: 27839743
Reprod Biomed Online. 2004 Oct;9(4):466-8
pubmed: 15511350
Antioxidants (Basel). 2020 Mar 06;9(3):
pubmed: 32155908
Fertil Steril. 2009 Mar;91(3):805-11
pubmed: 18314108
Andrologia. 2004 Oct;36(5):305-10
pubmed: 15458549
Hum Reprod. 2005 Nov;20(11):3101-8
pubmed: 16037114
Fertil Steril. 2014 Dec;102(6):1518-27
pubmed: 25458618
J Assist Reprod Genet. 2011 Mar;28(3):253-62
pubmed: 21072684
Curr Opin Urol. 2012 Nov;22(6):489-94
pubmed: 23026895
Methods Mol Biol. 2013;927:257-62
pubmed: 22992920
Mol Reprod Dev. 1993 Jul;35(3):302-15
pubmed: 8352936
Fertil Steril. 2013 Jan;99(1):63
pubmed: 23095139
Free Radic Biol Med. 2000 Feb 15;28(4):529-36
pubmed: 10719234
Andrologia. 2018 Apr;50(3):
pubmed: 29057493
Reprod Biomed Online. 2014 Jun;28(6):684-703
pubmed: 24745838
Reprod Biol Endocrinol. 2009 Oct 22;7:114
pubmed: 19849853
J Androl. 2011 Sep-Oct;32(5):484-90
pubmed: 21164144
Fertil Steril. 2010 Mar 1;93(4):1027-36
pubmed: 20080235
Urol Int. 2008;81(3):263-70
pubmed: 18931540
BJU Int. 2007 Oct;100(4):863-6
pubmed: 17559562
Reprod Biomed Online. 2016 Dec;33(6):668-683
pubmed: 27742259
Syst Biol Reprod Med. 2008 Jan-Feb;54(1):47-54
pubmed: 18543865
Andrologia. 2019 Jul;51(6):e13267
pubmed: 30873633
Chem Biol. 1995 Jul;2(7):437-45
pubmed: 9383446
Biol Reprod. 2004 Oct;71(4):1309-16
pubmed: 15189835
Fertil Steril. 2003 Apr;79(4):829-43
pubmed: 12749418
J Androl. 2001 Sep-Oct;22(5):798-803
pubmed: 11545292
J Androl. 2003 Nov-Dec;24(6):862-70
pubmed: 14581512
Aging Dis. 2015 Mar 10;6(2):109-20
pubmed: 25821639
J Androl. 2001 Jul-Aug;22(4):575-83
pubmed: 11451354
Mol Neurodegener. 2017 Nov 13;12(1):84
pubmed: 29132391
Hum Reprod. 2011 Jul;26(7):1628-40
pubmed: 21546386
Int J Urol. 2009 Feb;16(2):202-7
pubmed: 19183232
Fertil Steril. 2008 Oct;90(4):1103-8
pubmed: 18022168
J Androl. 1996 Sep-Oct;17(5):530-7
pubmed: 8957697
Fertil Steril. 2006 Sep;86(3):503-12
pubmed: 16860798
Reprod Biol Endocrinol. 2007 Apr 20;5:15
pubmed: 17448228
JBRA Assist Reprod. 2020 Jun 29;:
pubmed: 32598834
Fertil Steril. 2002 Sep;78(3):491-9
pubmed: 12215323
Nature. 1958 May 17;181(4620):1398-9
pubmed: 13552678
J Endocrinol Invest. 2013 Dec;36(11):970-4
pubmed: 23722985
Int J Androl. 2009 Feb;32(1):46-56
pubmed: 19076252
Andrology. 2016 Sep;4(5):800-7
pubmed: 27152678
Anal Biochem. 1990 Feb 1;184(2):193-9
pubmed: 2327564
Am J Reprod Immunol. 2008 Jan;59(1):2-11
pubmed: 18154591
Clin Biochem. 2009 May;42(7-8):589-94
pubmed: 19094977
Syst Biol Reprod Med. 2017 Jun;63(3):192-198
pubmed: 28332864
Int J Androl. 1997 Oct;20(5):255-64
pubmed: 16130269
World J Mens Health. 2019 Sep;37(3):296-312
pubmed: 31081299
J Androl. 2005 May-Jun;26(3):349-53
pubmed: 15867002
World J Mens Health. 2020 Jan 20;:
pubmed: 32009311
Hum Reprod. 2004 Mar;19(3):611-5
pubmed: 14998960
J Assist Reprod Genet. 2015 May;32(5):699-704
pubmed: 25813658
Biomed Rep. 2016 May;4(5):519-522
pubmed: 27123241
Fertil Steril. 2014 Oct;102(4):998-1005.e8
pubmed: 25190048
Andrologia. 2019 Feb;51(1):e13162
pubmed: 30259539
J Assist Reprod Genet. 2013 Sep;30(9):1147-56
pubmed: 23912751
Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11003-6
pubmed: 1763015
Adv Exp Med Biol. 1991;286:19-32
pubmed: 2042501
J Assist Reprod Genet. 1995 Feb;12(2):70-4
pubmed: 7545483
Hum Reprod. 2005 May;20(5):1339-48
pubmed: 15705620
Arch Ital Urol Androl. 2014 Mar 28;86(1):1-4
pubmed: 24704922
Hum Reprod. 2001 Sep;16(9):1912-21
pubmed: 11527898
Reprod Biomed Online. 2003 Oct-Nov;7(4):428-32
pubmed: 14656403
Carcinogenesis. 2003 Jan;24(1):63-73
pubmed: 12538350
J Androl. 2012 May-Jun;33(3):338-49
pubmed: 21835913
Fertil Steril. 1992 Jun;57(6):1289-93
pubmed: 1601152
Andrologia. 2019 Apr;51(3):e13201
pubmed: 30461041
Reprod Med Biol. 2019 Nov 28;19(1):89-94
pubmed: 31956290
Fertil Steril. 2013 Jun;99(7):1867-71
pubmed: 23490166
Fertil Steril. 1995 Oct;64(4):868-70
pubmed: 7672165
Cochrane Database Syst Rev. 2019 Mar 14;3:CD007411
pubmed: 30866036
J Reprod Fertil. 1993 May;98(1):257-65
pubmed: 8345470
Fertil Steril. 1979 May;31(5):531-7
pubmed: 446777
Reprod Med Biol. 2017 Sep 27;16(4):354-363
pubmed: 29259489
Syst Biol Reprod Med. 2012 Jun;58(3):142-8
pubmed: 22432504
Hum Reprod Update. 2007 Mar-Apr;13(2):163-74
pubmed: 17099205
Ind Health. 2003 Jul;41(3):291-4
pubmed: 12916762
Fertil Steril. 2020 Mar;113(3):552-560.e3
pubmed: 32111479
Hum Reprod. 1999 Nov;14(11):2801-7
pubmed: 10548626
Int J Urol. 2012 Jun;19(6):538-50
pubmed: 22417329
Syst Biol Reprod Med. 2017 Apr;63(2):120-129
pubmed: 28301253
Oxid Med Cell Longev. 2017;2017:4535194
pubmed: 28744337
Asian J Androl. 2015 Jul-Aug;17(4):668-75
pubmed: 25652627
Andrologia. 2018 Oct;50(8):e13012
pubmed: 29644708
Asian J Androl. 2013 Jan;15(1):56-60
pubmed: 23147467
J Androl. 2002 Nov-Dec;23(6):737-52
pubmed: 12399514
Reprod Biol Endocrinol. 2004 Mar 23;2:12
pubmed: 15038829
J Reprod Fertil. 1987 Nov;81(2):459-69
pubmed: 2828610
Bioessays. 1994 Apr;16(4):259-67
pubmed: 8031303
J Androl. 2006 May-Jun;27(3):450-2
pubmed: 16339454
Syst Biol Reprod Med. 2020 Apr;66(2):122-128
pubmed: 32063036
Urol Int. 2012;88(1):102-6
pubmed: 22086312
Fertil Steril. 2004 Feb;81(2):349-54
pubmed: 14967372
J Obstet Gynaecol Res. 2020 Jul;46(7):1133-1139
pubmed: 32462746
Reprod Biomed Online. 2014 Jul;29(1):32-58
pubmed: 24813754
Syst Biol Reprod Med. 2019 Dec;65(6):430-436
pubmed: 31434522
J Fam Plann Reprod Health Care. 2002 Oct;28(4):211-3
pubmed: 12419067
Free Radic Biol Med. 2010 Jan 1;48(1):112-9
pubmed: 19837155
Reprod Biol Endocrinol. 2014 May 07;12:33
pubmed: 24885775
Fertil Steril. 1992 Feb;57(2):409-16
pubmed: 1735495
Reprod Biol Endocrinol. 2014 May 27;12:45
pubmed: 24884815
Fertil Steril. 2012 Mar;97(3):546-53
pubmed: 22265039
Fertil Steril. 2016 Sep 1;106(3):566-573.e10
pubmed: 27260688
Fertil Steril. 1995 Oct;64(4):825-31
pubmed: 7672157
Reprod Med Biol. 2017 Oct 04;17(1):44-51
pubmed: 29371820
Int Braz J Urol. 2012 Sep-Oct;38(5):576-94
pubmed: 23131516
Rev Reprod. 1997 Jan;2(1):48-54
pubmed: 9414465
Environ Health Prev Med. 2008 Mar;13(2):102-8
pubmed: 19568888
Indian J Physiol Pharmacol. 2006 Jul-Sep;50(3):291-6
pubmed: 17193902
Int J Androl. 1993 Apr;16(2):165-6
pubmed: 8514430
J Assist Reprod Genet. 2015 Apr;32(4):509-20
pubmed: 25646893
Reprod Biomed Online. 2007 Apr;14(4):418-21
pubmed: 17425820
Fertil Steril. 2010 Feb;93(2):598-604
pubmed: 19393999
Andrologia. 2019 Dec;51(11):e13432
pubmed: 31583745
Syst Biol Reprod Med. 2014 Aug;60(4):206-16
pubmed: 24815996
Hum Reprod. 2010 Nov;25(11):2708-20
pubmed: 20823111
Urol J. 2015 Nov 14;12(5):2304-16
pubmed: 26571312
Andrologia. 2020 May 12;:e13624
pubmed: 32400041
Andrologia. 2006 Dec;38(6):221-4
pubmed: 17081174