Overloaded Adeno-Associated Virus as a Novel Gene Therapeutic Tool for Otoferlin-Related Deafness.
AAV (adeno-associated virus)
Auditory Neuroscience
deafness/hearing loss
gene therapy and therapeutic delivery
in vivo
organotypic culture model
otoferlin
preclinical
Journal
Frontiers in molecular neuroscience
ISSN: 1662-5099
Titre abrégé: Front Mol Neurosci
Pays: Switzerland
ID NLM: 101477914
Informations de publication
Date de publication:
2020
2020
Historique:
received:
28
08
2020
accepted:
04
12
2020
entrez:
25
1
2021
pubmed:
26
1
2021
medline:
26
1
2021
Statut:
epublish
Résumé
Hearing impairment is the most common sensory disorder in humans. So far, rehabilitation of profoundly deaf subjects relies on direct stimulation of the auditory nerve through cochlear implants. However, in some forms of genetic hearing impairment, the organ of Corti is structurally intact and therapeutic replacement of the mutated gene could potentially restore near natural hearing. In the case of defects of the otoferlin gene (
Identifiants
pubmed: 33488357
doi: 10.3389/fnmol.2020.600051
pmc: PMC7817888
doi:
Types de publication
Journal Article
Langues
eng
Pagination
600051Informations de copyright
Copyright © 2021 Rankovic, Vogl, Dörje, Bahader, Duque-Afonso, Thirumalai, Weber, Kusch, Strenzke and Moser.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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