Systematic review: the impact of inflammatory bowel disease-related fatigue on health-related quality of life.
Crohn’s disease
fatigue
health related quality of life
inflammatory bowel disease
ulcerative colitis
Journal
Frontline gastroenterology
ISSN: 2041-4137
Titre abrégé: Frontline Gastroenterol
Pays: England
ID NLM: 101528589
Informations de publication
Date de publication:
2021
2021
Historique:
received:
29
10
2019
revised:
06
01
2020
accepted:
07
01
2020
entrez:
25
1
2021
pubmed:
26
1
2021
medline:
26
1
2021
Statut:
epublish
Résumé
Fatigue is frequently reported in inflammatory bowel disease (IBD) and impacts on health-related quality of life (HRQoL). HRQoL has not been systematically reviewed in IBD fatigue. To investigate what impact IBD fatigue has on HRQoL in adults with IBD. Systematic searches (CINAHL, EMBASE, PsychINFO, Medline) were conducted on 25 September 2018, restricted to 'human', 'adult', 'primary research' and 'English language'. Search terms encompassed concepts of 'fatigue', 'IBD' and 'HRQoL'. A 5-year time limit (2013-2018) was set to include the most relevant publications. Publications were screened, data extracted and quality appraised by two authors. A narrative synthesis was conducted. Eleven studies were included, presenting data from 2823 participants. Fatigue experiences were significantly related to three HRQoL areas: symptom acceptance, psychosocial well-being and physical activity. Patients reporting high fatigue levels had low symptom acceptance. Psychosocial factors were strongly associated with both fatigue and HRQoL. Higher social support levels were associated with higher HRQoL. Physical activity was impaired by higher fatigue levels, lowering HRQoL, but it was also used as a means of reducing fatigue and improving HRQoL. Quality appraisal revealed methodological shortcomings in a number of studies. Notably, use of multiple measures, comparison without statistical adjustment and fatigue and HRQoL assessment using the same tool were some of the methodological shortcomings. Psychosocial factors, symptom management and acceptance and physical activity levels have significant impact on HRQoL. Results support application of psychosocial or exercise interventions for fatigue management. Further exploration of HRQoL factors in IBD fatigue is required, using validated fatigue and HRQoL measures. CRD42018110005.
Sections du résumé
BACKGROUND
BACKGROUND
Fatigue is frequently reported in inflammatory bowel disease (IBD) and impacts on health-related quality of life (HRQoL). HRQoL has not been systematically reviewed in IBD fatigue.
AIM
OBJECTIVE
To investigate what impact IBD fatigue has on HRQoL in adults with IBD.
METHODS
METHODS
Systematic searches (CINAHL, EMBASE, PsychINFO, Medline) were conducted on 25 September 2018, restricted to 'human', 'adult', 'primary research' and 'English language'. Search terms encompassed concepts of 'fatigue', 'IBD' and 'HRQoL'. A 5-year time limit (2013-2018) was set to include the most relevant publications. Publications were screened, data extracted and quality appraised by two authors. A narrative synthesis was conducted.
RESULTS
RESULTS
Eleven studies were included, presenting data from 2823 participants. Fatigue experiences were significantly related to three HRQoL areas: symptom acceptance, psychosocial well-being and physical activity. Patients reporting high fatigue levels had low symptom acceptance. Psychosocial factors were strongly associated with both fatigue and HRQoL. Higher social support levels were associated with higher HRQoL. Physical activity was impaired by higher fatigue levels, lowering HRQoL, but it was also used as a means of reducing fatigue and improving HRQoL. Quality appraisal revealed methodological shortcomings in a number of studies. Notably, use of multiple measures, comparison without statistical adjustment and fatigue and HRQoL assessment using the same tool were some of the methodological shortcomings.
CONCLUSION
CONCLUSIONS
Psychosocial factors, symptom management and acceptance and physical activity levels have significant impact on HRQoL. Results support application of psychosocial or exercise interventions for fatigue management. Further exploration of HRQoL factors in IBD fatigue is required, using validated fatigue and HRQoL measures.
PROSPERO REGISTRATION NUMBER
UNASSIGNED
CRD42018110005.
Identifiants
pubmed: 33489066
doi: 10.1136/flgastro-2019-101355
pii: flgastro-2019-101355
pmc: PMC7802486
doi:
Types de publication
Journal Article
Langues
eng
Pagination
11-21Informations de copyright
© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Aliment Pharmacol Ther. 2010 Jul;32(2):131-43
pubmed: 20456309
Biomed Pharmacother. 2000 Aug;54(7):388-93
pubmed: 10989978
Inflamm Bowel Dis. 2014 Mar;20(3):545-52
pubmed: 24407484
J Crohns Colitis. 2017 Feb;11(2):204-211
pubmed: 27506537
Aliment Pharmacol Ther. 2013 Mar;37(5):505-16
pubmed: 23311461
J Psychosom Res. 2004 Feb;56(2):157-70
pubmed: 15016573
Arq Gastroenterol. 2014 Jul-Sep;51(3):192-7
pubmed: 25296078
Aliment Pharmacol Ther. 2005 Mar 1;21(5):499-508
pubmed: 15740531
Dig Dis Sci. 1989 Sep;34(9):1379-86
pubmed: 2766905
Br J Nurs. 2016 Jun 23;25(12):649-60
pubmed: 27345064
Gut. 2011 May;60(5):571-607
pubmed: 21464096
J Gerontol B Psychol Sci Soc Sci. 2000 Nov;55(6):P362-72
pubmed: 11078106
J Clin Epidemiol. 1994 Jul;47(7):719-30
pubmed: 7722585
Holist Nurs Pract. 2017 Jan/Feb;31(1):30-41
pubmed: 27782921
Int J Nurs Stud. 2003 Sep;40(7):707-17
pubmed: 12965162
BMC Musculoskelet Disord. 2008 May 01;9:63
pubmed: 18452607
PLoS One. 2017 Jul 27;12(7):e0181435
pubmed: 28749985
Aliment Pharmacol Ther. 2017 Feb;45(3):403-416
pubmed: 27868215
BMJ. 2002 Aug 31;325(7362):480-3
pubmed: 12202331
J Psychosom Res. 2010 Jul;69(1):43-9
pubmed: 20630262
J Affect Disord. 2012 Dec 10;141(2-3):130-42
pubmed: 22578888
Inflamm Bowel Dis. 2009 Aug;15(8):1224-32
pubmed: 19180581
J Pain Symptom Manage. 2009 Jan;37(1):107-28
pubmed: 19111779
Behav Res Ther. 2004 Apr;42(4):367-83
pubmed: 14998732
BMJ. 1994 Mar 19;308(6931):763-6
pubmed: 7908238
Qual Life Res. 2011 Nov;20(9):1391-9
pubmed: 21424542
Syst Rev. 2017 Dec 06;6(1):245
pubmed: 29208034
J Clin Nurs. 2010 Jan;19(1-2):79-88
pubmed: 20500246
Res Synth Methods. 2015 Mar;6(1):87-95
pubmed: 26035472
Qual Life Res. 2008 Aug;17(6):877-86
pubmed: 18521720
J Health Soc Behav. 2000 Mar;41(1):50-67
pubmed: 10750322
J Clin Nurs. 2015 Sep;24(17-18):2659-67
pubmed: 26111098
J Clin Nurs. 2005 Jan;14(1):65-73
pubmed: 15656850
Psychosom Med. 2003 Jul-Aug;65(4):542-7
pubmed: 12883103
J Crohns Colitis. 2017 Mar 1;11(3):353-359
pubmed: 27664273
J Health Soc Behav. 2010;51 Suppl:S54-66
pubmed: 20943583
Ann Intern Med. 1994 Dec 15;121(12):953-9
pubmed: 7978722
Cochrane Database Syst Rev. 2012 Nov 14;11:CD006145
pubmed: 23152233
Ann Intern Med. 2015 Jun 16;162(12):834-40
pubmed: 26075754
Soc Sci Med. 1995 Nov;41(10):1403-9
pubmed: 8560308
Eur J Public Health. 2010 Jun;20(3):251-7
pubmed: 19689970
Disabil Rehabil. 2012;34(16):1376-84
pubmed: 22256799
Inflamm Bowel Dis. 2014 Jan;20(1):115-25
pubmed: 24297056
Aliment Pharmacol Ther. 2014 Apr;39(8):811-22
pubmed: 24612278
Clin Res Hepatol Gastroenterol. 2011 Feb;35(2):117-24
pubmed: 21036501
Dig Dis. 2010;28(3):463-71
pubmed: 20926873
Aliment Pharmacol Ther. 2002 Sep;16(9):1603-9
pubmed: 12197839
Am J Gastroenterol. 2001 Jun;96(6):1816-21
pubmed: 11419835
Br J Community Nurs. 2012 Oct;17(10):466, 468-72
pubmed: 23124372
World J Gastroenterol. 2018 Jul 28;24(28):3055-3070
pubmed: 30065553
Lancet. 1999 Sep 11;354(9182):936-9
pubmed: 10489969
Clin Rehabil. 2008 Mar;22(3):206-14
pubmed: 18285430
Qual Life Res. 2014 Mar;23(2):707-17
pubmed: 23975381
Ann Gastroenterol. 2013;26(1):52-58
pubmed: 24714294
Gastroenterol Hepatol (N Y). 2012 Mar;8(3):173-81
pubmed: 22675279
Psychosoc Med. 2005 Jun 27;2:Doc07
pubmed: 19742065
Scand J Gastroenterol. 2010 Jun;45(6):696-706
pubmed: 20334474
Am J Gastroenterol. 2003 May;98(5):1088-93
pubmed: 12809832
J Adv Nurs. 2013 Sep;69(9):1987-99
pubmed: 23215959
J Res Med Sci. 2017 Sep 26;22:104
pubmed: 29026420
Clin Sci (Lond). 2000 Jul;99(1):1-8
pubmed: 10887052
Rev Esp Enferm Dig. 2013 Mar;105(3):144-53
pubmed: 23735021
Future Oncol. 2008 Oct;4(5):717-33
pubmed: 18922128
Inflamm Bowel Dis. 2010 Dec;16(12):2137-47
pubmed: 20848468