Fulminant
Acute lymphoblastic leukemia relapse
Allogeneic hematopoietic stem cell transplantation
Mucormycosis
Pediatric patients
Rhizomucor pusillus
Journal
Medical mycology case reports
ISSN: 2211-7539
Titre abrégé: Med Mycol Case Rep
Pays: Netherlands
ID NLM: 101598259
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
02
11
2020
revised:
21
12
2020
accepted:
21
12
2020
entrez:
25
1
2021
pubmed:
26
1
2021
medline:
26
1
2021
Statut:
epublish
Résumé
This is the first published case report of a child with acute lymphatic leukemia developing a fatal mucormycosis during blinatumomab treatment. The patient showed multiple, systemic thromboembolic lesions with ischemia, bleeding and infarction in almost all organs. The child succumbed to increased brain pressure resulting in cerebral herniation. This case particularly illustrates the fulminant progression and huge challenges of diagnosing and treating mucormycosis in children with hemato-oncological diseases during treatment with targeted therapeutic antibodies (blinatumomab).
Identifiants
pubmed: 33489743
doi: 10.1016/j.mmcr.2020.12.002
pii: S2211-7539(20)30065-8
pmc: PMC7806943
doi:
Types de publication
Case Reports
Langues
eng
Pagination
4-9Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
No conflicts of interest are declared. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sector.
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