Serpins in Hemostasis as Therapeutic Targets for Bleeding or Thrombotic Disorders.
antithrombin (AT)
plasminogen activator inhibitor 1 (PAI-1)
protease nexin I (PN-1)
protein Z-dependent protease inhibitor (ZPI)
serpin (serine proteinase inhibitor)
therapy
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2020
2020
Historique:
received:
29
10
2020
accepted:
10
12
2020
entrez:
25
1
2021
pubmed:
26
1
2021
medline:
26
1
2021
Statut:
epublish
Résumé
Bleeding and thrombotic disorders result from imbalances in coagulation or fibrinolysis, respectively. Inhibitors from the serine protease inhibitor (serpin) family have a key role in regulating these physiological events, and thus stand out as potential therapeutic targets for modulating fibrin clot formation or dismantling. Here, we review the diversity of serpin-targeting strategies in the area of hemostasis, and detail the suggested use of modified serpins and serpin inhibitors (ranging from small-molecule drugs to antibodies) to treat or prevent bleeding or thrombosis.
Identifiants
pubmed: 33490121
doi: 10.3389/fcvm.2020.622778
pmc: PMC7817699
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
622778Informations de copyright
Copyright © 2021 Bianchini, Auditeau, Razanakolona, Vasse and Borgel.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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