Clinical updates on phantom limb pain.

Acute pain management Amputation Coanalgesics Regional analgesia Stump pain

Journal

Pain reports
ISSN: 2471-2531
Titre abrégé: Pain Rep
Pays: United States
ID NLM: 101683899

Informations de publication

Date de publication:
Historique:
received: 23 07 2020
revised: 13 10 2020
accepted: 12 11 2020
entrez: 25 1 2021
pubmed: 26 1 2021
medline: 26 1 2021
Statut: epublish

Résumé

Most patients with amputation (up to 80%) suffer from phantom limb pain postsurgery. These are often multimorbid patients who also have multiple risk factors for the development of chronic pain from a pain medicine perspective. Surgical removal of the body part and sectioning of peripheral nerves result in a lack of afferent feedback, followed by neuroplastic changes in the sensorimotor cortex. The experience of severe pain, peripheral, spinal, and cortical sensitization mechanisms, and changes in the body scheme contribute to chronic phantom limb pain. Psychosocial factors may also affect the course and the severity of the pain. Modern amputation medicine is an interdisciplinary responsibility. This review aims to provide an interdisciplinary overview of recent evidence-based and clinical knowledge. The scientific evidence for best practice is weak and contrasted by various clinical reports describing the polypragmatic use of drugs and interventional techniques. Approaches to restore the body scheme and integration of sensorimotor input are of importance. Modern techniques, including apps and virtual reality, offer an exciting supplement to already established approaches based on mirror therapy. Targeted prosthesis care helps to obtain or restore limb function and at the same time plays an important role reshaping the body scheme. Consequent prevention and treatment of severe postoperative pain and early integration of pharmacological and nonpharmacological interventions are required to reduce severe phantom limb pain. To obtain or restore body function, foresighted surgical planning and technique as well as an appropriate interdisciplinary management is needed.

Identifiants

pubmed: 33490849
doi: 10.1097/PR9.0000000000000888
pii: PAINREPORTS-D-20-0077
pmc: PMC7813551
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e888

Informations de copyright

Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain.

Déclaration de conflit d'intérêts

The authors have no conflicts of interest to declare.Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article.

Références

Ann Surg. 2019 Aug;270(2):238-246
pubmed: 30371518
Disabil Rehabil. 2009;31(10):846-54
pubmed: 19191061
Pain. 2008 Jul 31;137(3):600-608
pubmed: 18054437
Brain. 2003 Mar;126(Pt 3):579-89
pubmed: 12566279
Neuroscience. 2018 Sep 1;387:85-91
pubmed: 29155276
Int J Rehabil Res. 2010 Sep;33(3):279-82
pubmed: 20101187
Neurosci Lett. 2003 May 1;341(2):167-9
pubmed: 12686392
Int J Rehabil Res. 2017 Sep;40(3):209-214
pubmed: 28368869
Pain. 2010 May;149(2):296-304
pubmed: 20359825
J Neuroeng Rehabil. 2017 May 22;14(1):41
pubmed: 28532464
J Pain Res. 2017 Aug 07;10:1861-1870
pubmed: 28860841
Brain. 2008 Aug;131(Pt 8):2181-91
pubmed: 18567624
J Neurol Neurosurg Psychiatry. 2019 Jul;90(7):833-836
pubmed: 30100550
Scand J Pain. 2019 Jul 04;19(4):779-787
pubmed: 31271563
Arch Phys Med Rehabil. 1993 Jan;74(1):79-91
pubmed: 8380543
Nat Med. 2019 Sep;25(9):1356-1363
pubmed: 31501600
Behav Res Methods. 2014 Sep;46(3):634-40
pubmed: 24338625
Prosthet Orthot Int. 2018 Feb;42(1):66-74
pubmed: 28190380
Ann R Coll Surg Engl. 1994 Sep;76(5):324-6
pubmed: 7979074
Neurorehabil Neural Repair. 2012 Jul-Aug;26(6):646-52
pubmed: 22331213
J Rehabil Res Dev. 2005 Sep-Oct;42(5):645-54
pubmed: 16586190
IEEE Trans Neural Syst Rehabil Eng. 2008 Feb;16(1):46-50
pubmed: 18303805
Pain. 1992 Jan;48(1):21-27
pubmed: 1738570
Front Neurosci. 2016 May 12;10:209
pubmed: 27242413
Ann Neurol. 2019 Jan;85(1):59-73
pubmed: 30383312
J Cogn Neurosci. 1999 Sep;11(5):491-501
pubmed: 10511638
Front Hum Neurosci. 2017 Jun 20;11:319
pubmed: 28676749
Anesth Analg. 2004 Feb;98(2):408-413
pubmed: 14742379
Gen Dent. 2014 Sep-Oct;62(5):19-21
pubmed: 25184709
Eur J Vasc Endovasc Surg. 2014 Nov;48(5):559-64
pubmed: 25139251
Brain. 2006 Aug;129(Pt 8):2202-10
pubmed: 16844715
J Rehabil Res Dev. 2012;49(10):1457-66
pubmed: 23516050
Cyberpsychol Behav. 2006 Apr;9(2):167-70
pubmed: 16640472
Medicine (Baltimore). 2017 Sep;96(37):e8031
pubmed: 28906391
Ann Neurol. 2008 Dec;64(6):644-53
pubmed: 19107992
Eur J Pain. 2007 May;11(4):428-36
pubmed: 16857400
Anesthesiology. 2009 Sep;111(3):657-77
pubmed: 19672167
J Hand Surg Am. 2012 Aug;37(8):1609-16
pubmed: 22770416
Pain. 2002 Jan;95(1-2):133-42
pubmed: 11790476
Expert Rev Neurother. 2008 May;8(5):809-18
pubmed: 18457537
Acta Ophthalmol. 2010 Dec;88 Thesis 2:1-26
pubmed: 21108770
Disabil Rehabil. 2007 Sep 30;29(18):1465-9
pubmed: 17729094
Neurosurgery. 2003 Mar;52(3):675-86; discussion 685-6
pubmed: 12590694
J Bone Joint Surg Am. 1996 Oct;78(10):1501-5
pubmed: 8876577
Pain Med. 2012 Dec;13(12):1611-26
pubmed: 23013457
Nature. 1995 Oct 12;377(6549):489-90
pubmed: 7566144
Scand J Pain. 2018 Jan 26;18(1):3-17
pubmed: 29794290
Clin Rehabil. 2010 May;24(5):444-53
pubmed: 20442256
Vasa. 2015 Sep;44(5):381-6
pubmed: 26317258
Sci Rep. 2014 Jun 16;4:5298
pubmed: 24931344
Acta Neurol Scand. 2003 Sep;108(3):179-84
pubmed: 12911461
Neurosurgery. 2001 Sep;49(3):736-41; discussion 741-2
pubmed: 11523688
Muscle Nerve. 2019 Feb;59(2):154-167
pubmed: 30152101
Anesthesiology. 2011 May;114(5):1144-54
pubmed: 21368651
Ann Surg Oncol. 2003 Apr;10(3):268-74
pubmed: 12679312
Lancet. 1997 Nov 8;350(9088):1353-7
pubmed: 9365449
Clin Rehabil. 1998 Aug;12(4):348-53
pubmed: 9744670
Med Hypotheses. 2014 Jan;82(1):77-85
pubmed: 24296234
Sci Rep. 2020 Jul 13;10(1):11504
pubmed: 32661345
Clin J Pain. 2013 Jun;29(6):551-62
pubmed: 23328317
Neurol Neurochir Pol. 2014 Jan-Feb;48(1):52-9
pubmed: 24636771
Schmerz. 2006 Aug;20(4):300, 302-6
pubmed: 16254723
Pain. 1997 Sep;72(3):393-405
pubmed: 9313280
Wien Klin Wochenschr. 2019 Dec;131(23-24):599-607
pubmed: 31201567
Reg Anesth Pain Med. 2001 Jul-Aug;26(4):316-21
pubmed: 11464349
Clin J Pain. 2012 Feb;28(2):108-12
pubmed: 21750460
Arch Phys Med Rehabil. 2004 Jan;85(1):1-6
pubmed: 14970960
Am J Phys Med Rehabil. 2012 Aug;91(8):701-14
pubmed: 22286895
Arch Phys Med Rehabil. 2000 Aug;81(8):1039-44
pubmed: 10943752
Pain Med. 2009 Mar;10(2):300-3
pubmed: 19207237
J Pain. 2016 Feb;17(2):131-57
pubmed: 26827847
Neurosci Biobehav Rev. 2008;32(1):143-60
pubmed: 17707508
ScientificWorldJournal. 2014;2014:686493
pubmed: 25548790
Anesth Analg. 2008 Apr;106(4):1265-73, table of contents
pubmed: 18349204
Clin Orthop Relat Res. 1991 May;(266):227-37
pubmed: 2019056
Brain. 2001 Nov;124(Pt 11):2268-77
pubmed: 11673327
Br J Pain. 2018 Nov;12(4):202-207
pubmed: 30349693
J Pain Symptom Manage. 1999 Feb;17(2):125-42
pubmed: 10069153
Eur J Pain. 2000;4(4):327-34
pubmed: 11124004
Reg Anesth Pain Med. 2002 Sep-Oct;27(5):481-6
pubmed: 12373695
Int J Rehabil Res. 1989;12(2):175-86
pubmed: 2696733
Stud Health Technol Inform. 2006;119:407-12
pubmed: 16404088
Pain. 1996 Sep;67(1):69-77
pubmed: 8895233
Cochrane Database Syst Rev. 2016 Oct 14;10:CD006380
pubmed: 27737513
Trends Cogn Sci. 2013 Jul;17(7):307-8
pubmed: 23608362
Neurosci Lett. 2012 Jan 24;507(2):97-100
pubmed: 22085692
Pain Med. 2017 Sep 1;18(9):1745-1751
pubmed: 28100669
Expert Rev Med Devices. 2013 Jan;10(1):45-54
pubmed: 23278223
J Trauma. 2008 Oct;65(4):858-64
pubmed: 18849803
Nat Rev Neurosci. 2006 Nov;7(11):873-81
pubmed: 17053811
Pain. 2003 Jun;103(3):277-283
pubmed: 12791434
Disabil Rehabil Assist Technol. 2012 Jul;7(4):294-303
pubmed: 22112174
Brain. 2008 Dec;131(Pt 12):3443-52
pubmed: 19074189
Pain. 2008 Mar;135(1-2):108-18
pubmed: 17583431
Neuroimage. 2003 Nov;20 Suppl 1:S107-11
pubmed: 14597303
Anesthesiology. 2002 Apr;96(4):841-8
pubmed: 11964590
J Neural Eng. 2018 Dec;15(6):066022
pubmed: 30229747
Perception. 2010;39(1):103-18
pubmed: 20301851
J Psychosom Res. 1973 Mar;17(2):97-108
pubmed: 4741689
Pain Res Manag. 2010 Mar-Apr;15(2):65-71
pubmed: 20458374
Pain Res Manag. 2018 Jun 21;2018:5080123
pubmed: 30057653
Am Surg. 2008 Apr;74(4):285-96
pubmed: 18453290
Pain. 1987 Mar;28(3):285-295
pubmed: 3554115
J Am Coll Surg. 2019 Mar;228(3):217-226
pubmed: 30634038
J Neurol. 1997 Mar;244(3):199-203
pubmed: 9050962
Neurosci Lett. 1999 Sep 10;272(2):131-4
pubmed: 10507559
J Pain Symptom Manage. 2002 Oct;24(4):429-36
pubmed: 12505212
Science. 1964 Feb 7;143(3606):594-6
pubmed: 14080333
J Rehabil Res Dev. 1994 Aug;31(3):179-87
pubmed: 7965876
J Physiol Paris. 2009 Sep-Dec;103(3-5):255-62
pubmed: 19665563
N Engl J Med. 2007 Nov 22;357(21):2206-7
pubmed: 18032777
Anesth Analg. 1991 Mar;72(3):300-3
pubmed: 1994757
Pain Pract. 2018 Jul;18(6):709-715
pubmed: 29105971
Pain. 2008 Aug 15;138(1):7-10
pubmed: 18621484
J Neural Eng. 2017 Jun;14(3):036007
pubmed: 28355147
Pain. 2015 Jul;156(7):1284-1300
pubmed: 25830925
Pain Med. 2016 Jan;17(1):149-61
pubmed: 26177330
Eur J Pain. 2018 Oct;22(9):1547-1564
pubmed: 30074291
Pain. 2001 Feb 1;90(1-2):47-55
pubmed: 11166969
Eur J Anaesthesiol. 2008 May;25(5):424-5
pubmed: 18377665
Nat Commun. 2013;4:1570
pubmed: 23463013
Eur J Pain. 2014 May;18(5):729-39
pubmed: 24327313
Anesth Analg. 2010 Nov;111(5):1308-15
pubmed: 20881281
J Pain. 2007 Feb;8(2):102-9
pubmed: 16949876
Front Neurol. 2018 Apr 26;9:270
pubmed: 29755399
Lancet. 2001 Jun 2;357(9270):1763-4
pubmed: 11403816
J Rehabil Med. 2009 May;41(6):418-22
pubmed: 19479153
PLoS One. 2018 Jul 16;13(7):e0200548
pubmed: 30011306
Trends Cogn Sci. 2017 Mar;21(3):195-204
pubmed: 28214130
Clin Rehabil. 2005 Jan;19(1):81-6
pubmed: 15704512
Schmerz. 2014 Aug;28(4):374-83
pubmed: 24939242
Neurosci Lett. 2019 May 29;702:44-50
pubmed: 30503915
Nat Neurosci. 1999 Jun;2(6):501-2
pubmed: 10448212
Nature. 1995 Jun 8;375(6531):482-4
pubmed: 7777055
Lancet Neurol. 2002 Jul;1(3):182-9
pubmed: 12849487
IEEE Trans Neural Syst Rehabil Eng. 2005 Dec;13(4):468-72
pubmed: 16425828
Arch Phys Med Rehabil. 2004 May;85(5):723-9
pubmed: 15129395
J Neural Eng. 2016 Oct;13(5):056010
pubmed: 27547992
Cochrane Database Syst Rev. 2015 Aug 18;8:CD007264
pubmed: 26284511
Pain. 1988 Jun;33(3):297-301
pubmed: 3419837
Expert Rev Neurother. 2009 May;9(5):723-44
pubmed: 19402781
J Rehabil Res Dev. 2008;45(1):15-29
pubmed: 18566923
Scott Med J. 2008 Feb;53(1):4-6
pubmed: 18422201
Brain Res Bull. 2019 May;148:1-9
pubmed: 30862485
J Pain. 2007 Oct;8(10):793-801
pubmed: 17631056
Lancet. 2001 Sep 22;358(9286):1015
pubmed: 11586989

Auteurs

Joachim Erlenwein (J)

Department of Anesthesiology, Pain Clinic, University Hospital, Georg-August-University of Göttingen, Göttingen, Germany.

Martin Diers (M)

Department of Psychosomatic Medicine and Psychotherapy, LWL University Hospital, Ruhr University Bochum, Bochum, Germany.

Jennifer Ernst (J)

Department of Trauma Surgery, Orthopaedics and Plastic Surgery, University of Göttingen, Göttingen, Germany.

Friederike Schulz (F)

Clinic of Anaesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.

Frank Petzke (F)

Department of Anesthesiology, Pain Clinic, University Hospital, Georg-August-University of Göttingen, Göttingen, Germany.

Classifications MeSH