Hydroxychloroquine can impair tumor response to anti-PD1 in subcutaneous mouse models.
Cancer
Immunology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
22 Jan 2021
22 Jan 2021
Historique:
received:
22
07
2020
revised:
23
10
2020
accepted:
21
12
2020
entrez:
25
1
2021
pubmed:
26
1
2021
medline:
26
1
2021
Statut:
epublish
Résumé
Hydroxychloroquine (HCQ) is a well-known anti-inflammatory drug but is also known as an anti-inflammatory drug. Here, we evaluate the influence of HCQ treatment on the effect of anti-PD1 tumor immunotherapy. Anti-PD1 therapy-sensitive tumor lines MC38, CT26, and RIL-175 were used to investigate the impact of HCQ on anti-PD1 therapy efficacy.
Identifiants
pubmed: 33490900
doi: 10.1016/j.isci.2020.101990
pii: S2589-0042(20)31187-1
pmc: PMC7807148
doi:
Types de publication
Journal Article
Langues
eng
Pagination
101990Déclaration de conflit d'intérêts
The authors declare no potential conflicts of interest.
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