Interferon Regulatory Factor-5 in Resident Macrophage Promotes Polycystic Kidney Disease.

Animals Interferon Regulatory Factors / genetics Kidney / metabolism Macrophages / metabolism Mice Polycystic Kidney Diseases / metabolism Polycystic Kidney, Autosomal Dominant / genetics

Journal

Kidney360
ISSN: 2641-7650
Titre abrégé: Kidney360
Pays: United States
ID NLM: 101766381

Informations de publication

Date de publication:
Mar 2020
Historique:
entrez: 25 1 2021
pubmed: 26 1 2021
medline: 26 1 2021
Statut: ppublish

Résumé

Autosomal dominant polycystic kidney disease is caused by genetic mutations in In these studies, we used conditional Analyses of qRT-PCR and IRF5 ASO treatment significantly reduced macrophage numbers, These data suggest that

Sections du résumé

BACKGROUND BACKGROUND
Autosomal dominant polycystic kidney disease is caused by genetic mutations in
METHODS METHODS
In these studies, we used conditional
RESULTS RESULTS
Analyses of qRT-PCR and IRF5 ASO treatment significantly reduced macrophage numbers,
CONCLUSIONS CONCLUSIONS
These data suggest that

Identifiants

DOI: 10.34067/KID.0001052019 PMID: 33490963 PMC: PMC7822573
pubmed: 33490963
doi: 10.34067/KID.0001052019
pmc: PMC7822573
mid: NIHMS1602475
doi:

Substances chimiques

Interferon Regulatory Factors 0
Irf5 protein, mouse 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Pagination

179-190

Subventions

Organisme : NIAID NIH HHS
ID : P30 AI027767
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007051
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK090868
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK074038
Pays : United States
Organisme : NIDDK NIH HHS
ID : R03 DK119717
Pays : United States
Organisme : BLRD VA
ID : I01 BX002298
Pays : United States
Organisme : BLRD VA
ID : I01 BX004232
Pays : United States
Organisme : NIDDK NIH HHS
ID : K08 DK106465
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA045300
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK079337
Pays : United States
Organisme : NIDDK NIH HHS
ID : U54 DK126114
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK097423
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK115752
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK065655
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR048311
Pays : United States

Références

Results Probl Cell Differ. 2017;60:323-344
pubmed: 28409351
Nephrol Dial Transplant. 2016 Nov;31(11):1826-1834
pubmed: 27190325
Hum Mol Genet. 2011 Nov 1;20(21):4143-54
pubmed: 21821671
Science. 2012 Apr 6;336(6077):86-90
pubmed: 22442384
J Physiol. 1971 Dec;219(3):507-23
pubmed: 5157591
EMBO J. 2018 Aug 1;37(15):
pubmed: 29925518
Hum Mol Genet. 2009 Jul 15;18(14):2523-31
pubmed: 19342421
J Clin Invest. 2015 Jun;125(6):2429-44
pubmed: 25985273
PLoS One. 2017 Dec 21;12(12):e0190009
pubmed: 29267404
Am J Physiol Renal Physiol. 2018 Feb 1;314(2):F210-F218
pubmed: 29021226
Physiol Rep. 2019 Jan;7(1):e13951
pubmed: 30632307
Kidney Int. 2015 Oct;88(4):722-33
pubmed: 26061548
J Clin Invest. 2015 Jun;125(6):2399-412
pubmed: 25961459
Am J Pathol. 1966 Jul;49(1):1-13
pubmed: 5944761
Physiol Res. 1999;48(4):267-79
pubmed: 10638678
Am J Physiol Renal Physiol. 2015 Jul 1;309(1):F79-87
pubmed: 25904703
Kidney Int. 2008 Jan;73(1):63-76
pubmed: 17960140
Nat Immunol. 2011 Mar;12(3):231-8
pubmed: 21240265
Proc Natl Acad Sci U S A. 2011 May 10;108(19):7985-90
pubmed: 21518865
J Am Soc Nephrol. 2019 May;30(5):767-781
pubmed: 30948627
Nat Med. 2007 Dec;13(12):1490-5
pubmed: 17965720
Kidney Int. 1983 Apr;23(4):611-5
pubmed: 6085954
Kidney Int. 2009 Apr;75(8):848-55
pubmed: 19165178
Hum Mol Genet. 2009 Jul 15;18(14):2532-42
pubmed: 19401297
J Am Soc Nephrol. 2014 Aug;25(8):1737-48
pubmed: 24578126
Nature. 2005 Mar 10;434(7030):243-9
pubmed: 15665823
Dev Biol. 2002 Apr 15;244(2):305-18
pubmed: 11944939
J Am Soc Nephrol. 2019 Oct;30(10):1841-1856
pubmed: 31337691
Mol Cell Biochem. 2006 Aug;288(1-2):179-89
pubmed: 16718380
J Am Soc Nephrol. 2011 Oct;22(10):1809-14
pubmed: 21921140
J Am Soc Nephrol. 2013 Feb;24(3):456-64
pubmed: 23411784
Am J Physiol Renal Physiol. 2016 May 15;310(10):F1000-7
pubmed: 27009340
Am J Physiol Renal Physiol. 2018 Sep 1;315(3):F479-F486
pubmed: 29513074
Am J Physiol Renal Physiol. 2019 Aug 1;317(2):F343-F360
pubmed: 31091126
Annu Rev Med. 2009;60:321-37
pubmed: 18947299
Am J Physiol Gastrointest Liver Physiol. 2018 Jun 1;314(6):G677-G689
pubmed: 29543508
J Clin Invest. 2019 Jul 30;129(10):4506-4522
pubmed: 31361604
Hum Mol Genet. 2008 Jun 1;17(11):1578-90
pubmed: 18263895
Am J Physiol Renal Physiol. 2011 May;300(5):F1193-202
pubmed: 21345977
J Am Soc Nephrol. 2011 May;22(5):839-48
pubmed: 21493775
Cell. 2016 Aug 11;166(4):991-1003
pubmed: 27477514
Mol Cell Biol. 2002 Aug;22(16):5721-40
pubmed: 12138184
J Am Soc Nephrol. 2018 Oct;29(10):2471-2481
pubmed: 30209078
Kidney Int. 2013 May;83(5):855-64
pubmed: 23423256
J Am Soc Nephrol. 2004 Dec;15(12):3035-43
pubmed: 15579506
FASEB J. 2016 Jan;30(1):370-9
pubmed: 26391272

Auteurs

Kurt A Zimmerman (KA)

Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama.

Jifeng Huang (J)

Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.

Lan He (L)

Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.

Dustin Z Revell (DZ)

Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama.

Zhang Li (Z)

Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama.

Jung-Shan Hsu (JS)

Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.

Wayne R Fitzgibbon (WR)

Division of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina.

E Starr Hazard (ES)

Academic Affairs Faculty and Computational Biology Resource Center, Medical University of South Carolina, Charleston, South Carolina.

Gary Hardiman (G)

School of Biological Sciences, Institute for Global Food Security, Queens University Belfast, Belfast, United Kingdom.

Michal Mrug (M)

Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
Birmingham Veterans Affairs Medical Center, Birmingham, Alabama.

P Darwin Bell (PD)

Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.

Bradley K Yoder (BK)

Department of Cell, Developmental, and Integrative Biology, University of Alabama at Birmingham, Birmingham, Alabama.

Takamitsu Saigusa (T)

Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.
ORCID: 0000-0002-2398-1572

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Classifications MeSH

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questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Interferon Regulatory Factor-5 in Resident...
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