Activation of the medial preoptic area (MPOA) ameliorates loss of maternal behavior in a Shank2 mouse model for autism.
SHANK3
autism spectrum disorders
bonding
social behavior
synapse
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
01 03 2021
01 03 2021
Historique:
received:
15
12
2019
revised:
09
12
2020
accepted:
16
12
2020
pubmed:
26
1
2021
medline:
21
10
2021
entrez:
25
1
2021
Statut:
ppublish
Résumé
Impairments in social relationships and awareness are features observed in autism spectrum disorders (ASDs). However, the underlying mechanisms remain poorly understood. Shank2 is a high-confidence ASD candidate gene and localizes primarily to postsynaptic densities (PSDs) of excitatory synapses in the central nervous system (CNS). We show here that loss of Shank2 in mice leads to a lack of social attachment and bonding behavior towards pubs independent of hormonal, cognitive, or sensitive deficits. Shank2
Identifiants
pubmed: 33491217
doi: 10.15252/embj.2019104267
pmc: PMC7917557
doi:
Substances chimiques
DREADD agonist compound 21
0
Nerve Tissue Proteins
0
Piperazines
0
Shank2 protein, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e104267Informations de copyright
© 2021 The Authors. Published under the terms of the CC BY NC ND 4.0 license.
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