Nrf2 mediates hypoxia-inducible HIF1α activation in kidney tubular epithelial cells.

Cell Hypoxia / genetics Epithelial Cells / metabolism Humans Hypoxia / metabolism Hypoxia-Inducible Factor 1, alpha Subunit / metabolism Kidney / metabolism NF-E2-Related Factor 2 / metabolism Proto-Oncogene Proteins c-akt / metabolism
acute kidney injury hypoxia-inducible factor-1α ischemia-reperfusion mitochondria nuclear factor erythroid 2-related factor 2

Journal

American journal of physiology. Renal physiology
ISSN: 1522-1466
Titre abrégé: Am J Physiol Renal Physiol
Pays: United States
ID NLM: 100901990

Informations de publication

Date de publication:
01 03 2021
Historique:
pubmed: 26 1 2021
medline: 29 4 2021
entrez: 25 1 2021
Statut: ppublish

Résumé

Nuclear factor erythroid 2-related factor 2 (Nrf2) and hypoxia-inducible factor-1α (HIF1α) transcription factors protect against ischemic acute kidney injury (AKI) by upregulating metabolic and cytoprotective gene expression. In this study, we tested the hypothesis that Nrf2 is required for HIF1α-mediated hypoxic responses using

Identifiants

DOI: 10.1152/ajprenal.00501.2020 PMID: 33491566 PMC: PMC7988808
pubmed: 33491566
doi: 10.1152/ajprenal.00501.2020
pmc: PMC7988808
doi:

Substances chimiques

Hypoxia-Inducible Factor 1, alpha Subunit 0
NF-E2-Related Factor 2 0
NFE2L2 protein, human 0
Proto-Oncogene Proteins c-akt EC 2.7.11.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

F464-F474

Subventions

Organisme : HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
ID : DK084445
Organisme : NIDDK NIH HHS
ID : R01 DK084445
Pays : United States
Organisme : HHS | NIH | National Institute of General Medical Sciences (NIGMS)
ID : GM124235
Organisme : NIGMS NIH HHS
ID : R01 GM124235
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL136946
Pays : United States
Organisme : HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI)
ID : HL136946

Références

Nat Commun. 2016 Dec 14;7:13593
pubmed: 27966538
Oxid Med Cell Longev. 2013;2013:798401
pubmed: 23738042
J Biol Chem. 2003 Jan 24;278(4):2396-402
pubmed: 12441344
Oncogene. 2005 Aug 25;24(36):5552-60
pubmed: 16007214
In Vitro Cell Dev Biol. 1988 Jul;24(7):683-95
pubmed: 2840432
Mol Cancer Res. 2008 Jul;6(7):1099-105
pubmed: 18644974
EMBO J. 2003 Aug 15;22(16):4082-90
pubmed: 12912907
Biochem Biophys Res Commun. 1999 Aug 2;261(2):534-40
pubmed: 10425220
Cell. 2012 Feb 3;148(3):399-408
pubmed: 22304911
EMBO Rep. 2012 Mar 01;13(3):251-7
pubmed: 22310300
J Biol Chem. 1997 Feb 28;272(9):5375-81
pubmed: 9038135
Kidney Int. 2009 Aug;76(3):277-85
pubmed: 19436334
PLoS One. 2012;7(2):e30470
pubmed: 22348009
J Biol Chem. 2003 Feb 14;278(7):4536-41
pubmed: 12446695
FASEB J. 2006 Dec;20(14):2624-6
pubmed: 17142801
Int J Cancer. 2014 Aug 1;135(3):574-84
pubmed: 24374745
Sci Rep. 2016 Dec 16;6:39123
pubmed: 27982118
Front Biosci (Landmark Ed). 2016 Jan 01;21:385-96
pubmed: 26709780
Biochem J. 2004 Aug 1;381(Pt 3):761-7
pubmed: 15104534
Annu Rev Pharmacol Toxicol. 2007;47:89-116
pubmed: 16968214
Am J Respir Cell Mol Biol. 2007 Feb;36(2):166-74
pubmed: 16990612
Front Oncol. 2017 Nov 27;7:286
pubmed: 29230384
J Clin Invest. 2012 Feb;122(2):600-11
pubmed: 22214851
Proc Natl Acad Sci U S A. 1995 Jun 6;92(12):5510-4
pubmed: 7539918
J Biol Chem. 2002 Nov 8;277(45):42769-74
pubmed: 12198130
FEBS Lett. 2008 Jul 9;582(16):2357-64
pubmed: 18538669
J Biol Chem. 2013 Jun 21;288(25):18393-405
pubmed: 23645672
Curr Pharm Des. 2003;9(30):2499-511
pubmed: 14529549
Cell. 2001 Oct 5;107(1):43-54
pubmed: 11595184
Biochem Biophys Res Commun. 1996 Jun 5;223(1):54-9
pubmed: 8660378
Int J Mol Sci. 2020 Apr 22;21(8):
pubmed: 32331329
Biochem Biophys Res Commun. 1996 Aug 14;225(2):485-8
pubmed: 8753788
Antioxid Redox Signal. 2016 Jul 20;25(3):165-83
pubmed: 26906116
Nat Rev Nephrol. 2019 Oct;15(10):641-659
pubmed: 31488900
Exp Cell Res. 2017 Jul 15;356(2):217-222
pubmed: 28327410
Cancer Res. 2011 Mar 15;71(6):2260-75
pubmed: 21278237
Genomics. 1998 Sep 1;52(2):159-65
pubmed: 9782081
Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12475-80
pubmed: 11035812
Lancet. 2019 Nov 23;394(10212):1949-1964
pubmed: 31777389
Am J Physiol Renal Physiol. 2016 Nov 1;311(5):F1025-F1034
pubmed: 27582105
Kidney Int. 2014 Jan;85(1):134-41
pubmed: 24088953
Kidney Int. 1995 Oct;48(4):1298-307
pubmed: 8569092

Auteurs

Haranatha R Potteti (HR)

Division of Developmental Biology and Basic Research, Department of Pediatrics, University of Illinois at Chicago, Chicago, Illinois.

Patrick M Noone (PM)

Division of Developmental Biology and Basic Research, Department of Pediatrics, University of Illinois at Chicago, Chicago, Illinois.

Chandramohan R Tamatam (CR)

Division of Developmental Biology and Basic Research, Department of Pediatrics, University of Illinois at Chicago, Chicago, Illinois.

Aparna Ankireddy (A)

Division of Developmental Biology and Basic Research, Department of Pediatrics, University of Illinois at Chicago, Chicago, Illinois.

Sanjeev Noel (S)

Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland.

Hamid Rabb (H)

Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland.

Sekhar P Reddy (SP)

Division of Developmental Biology and Basic Research, Department of Pediatrics, University of Illinois at Chicago, Chicago, Illinois.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Respiration cellulaire › Hypoxie cellulaire › Nrf2 mediates hypoxia-inducible HIF1α...
questionsmedicales.fr › Cellules › Cellules épithéliales › Nrf2 mediates hypoxia-inducible HIF1α...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Nrf2 mediates hypoxia-inducible HIF1α...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Hypoxie › Nrf2 mediates hypoxia-inducible HIF1α...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › Facteur-1 induit par l'hypoxie › Sous-unité alpha du facteur-1 induit par l'hypoxie › Nrf2 mediates hypoxia-inducible HIF1α...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Nrf2 mediates hypoxia-inducible HIF1α...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteur-2 apparenté à NF-E2 › Nrf2 mediates hypoxia-inducible HIF1α...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-akt › Nrf2 mediates hypoxia-inducible HIF1α...