Patient iPSC-derived retinal organoids: Observable retinal diseases in-a-dish.
Journal
Histology and histopathology
ISSN: 1699-5848
Titre abrégé: Histol Histopathol
Pays: Spain
ID NLM: 8609357
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
pubmed:
26
1
2021
medline:
2
2
2022
entrez:
25
1
2021
Statut:
ppublish
Résumé
Induced pluripotent stem cells (iPSCs), reprogrammed from human somatic cells, hold the capacity to differentiate into most human body cells. iPSCs can be differentiated into retinal organoids, a three-dimensional structured retina containing various retinal cells. Patient-specific retinal organoids provide a powerful disease model to recapitulate the disease to study the pathogenesis of inherited retinal dystrophies, to screen or discover new drugs, and most importantly to supply an unlimited cell source for retinal regeneration.
Identifiants
pubmed: 33491763
pii: HH-18-307
doi: 10.14670/HH-18-307
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
705-710Subventions
Organisme : Beijing Natural Science Foundation
ID : Z200014
Organisme : National Key RandD Program of China
ID : 2017YFA0105300
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