The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's disease.
Alzheimer's disease
magnetic resonance imaging
phosphorylated tau
plasma biomarkers
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
revised:
28
11
2020
received:
20
07
2020
accepted:
02
12
2020
pubmed:
26
1
2021
medline:
19
11
2021
entrez:
25
1
2021
Statut:
ppublish
Résumé
This study investigated the diagnostic and disease-monitoring potential of plasma biomarkers in mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia and cognitively unimpaired (CU) individuals. Plasma was analyzed using Simoa assays from 99 CU, 107 MCI, and 103 AD dementia participants. Phosphorylated-tau181 (P-tau181), neurofilament light, amyloid-β (Aβ42/40), Total-tau and Glial fibrillary acidic protein were altered in AD dementia but P-tau181 significantly outperformed all biomarkers in differentiating AD dementia from CU (area under the curve [AUC] = 0.91). P-tau181 was increased in MCI converters compared to non-converters. Higher P-tau181 was associated with steeper cognitive decline and gray matter loss in temporal regions. Longitudinal change of P-tau181 was strongly associated with gray matter loss in the full sample and with Aβ measures in CU individuals. P-tau181 detected AD at MCI and dementia stages and was strongly associated with cognitive decline and gray matter loss. These findings highlight the potential value of plasma P-tau181 as a non-invasive and cost-effective diagnostic and prognostic biomarker in AD.
Identifiants
pubmed: 33491853
doi: 10.1002/alz.12283
pmc: PMC8359457
doi:
Substances chimiques
Amyloid beta-Peptides
0
Biomarkers
0
tau Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1145-1156Informations de copyright
© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
Références
Neurology. 2019 Oct 22;93(17):e1647-e1659
pubmed: 31371569
Radiology. 1983 Sep;148(3):839-43
pubmed: 6878708
Neurology. 2016 Sep 27;87(13):1329-36
pubmed: 27581216
Neurology. 2018 Jan 30;90(5):e388-e395
pubmed: 29321235
Sci Rep. 2016 May 31;6:26801
pubmed: 27241045
Lancet Neurol. 2014 Jun;13(6):614-29
pubmed: 24849862
Alzheimers Dement. 2021 Jul;17(7):1145-1156
pubmed: 33491853
Front Neuroinform. 2016 Jun 15;10:20
pubmed: 27378902
J Neurol Neurosurg Psychiatry. 2020 Sep;91(9):960-967
pubmed: 32611664
Alzheimers Dement. 2011 May;7(3):263-9
pubmed: 21514250
Alzheimers Dement. 2018 Apr;14(4):535-562
pubmed: 29653606
J Neurol Neurosurg Psychiatry. 2019 Feb;90(2):157-164
pubmed: 30309882
JAMA. 2018 Sep 18;320(11):1151-1162
pubmed: 30326496
Med Image Anal. 2003 Dec;7(4):513-27
pubmed: 14561555
Acta Neuropathol Commun. 2019 Jan 9;7(1):5
pubmed: 30626432
Lancet Neurol. 2016 Jun;15(7):673-684
pubmed: 27068280
JAMA. 2020 Aug 25;324(8):772-781
pubmed: 32722745
Neuroimage. 2000 Jun;11(6 Pt 1):805-21
pubmed: 10860804
IEEE Trans Med Imaging. 1998 Feb;17(1):87-97
pubmed: 9617910
Neurology. 2017 Mar 7;88(10):930-937
pubmed: 28179466
JAMA Neurol. 2019 Jul 1;76(7):791-799
pubmed: 31009028
Acta Neuropathol. 2020 Sep;140(3):267-278
pubmed: 32720099
JAMA Neurol. 2016 Jan;73(1):60-7
pubmed: 26524180
Arch Neurol. 1999 Mar;56(3):303-8
pubmed: 10190820
Mol Cell Neurosci. 2019 Jun;97:18-33
pubmed: 30529601
J Nutr Health Aging. 2007 Jul-Aug;11(4):359-61
pubmed: 17653500
Nat Med. 2020 Mar;26(3):387-397
pubmed: 32123386
Ann Clin Transl Neurol. 2016 Feb 01;3(3):216-25
pubmed: 27042681
BMC Bioinformatics. 2011 Mar 17;12:77
pubmed: 21414208
Alzheimers Dement (Amst). 2019 Sep 27;11:679-689
pubmed: 31673598
Neurology. 2017 Nov 14;89(20):2108-2114
pubmed: 29046363
Alzheimers Dement. 2018 Aug;14(8):989-997
pubmed: 29626426
Nat Med. 2020 Mar;26(3):379-386
pubmed: 32123385
Ann N Y Acad Sci. 2009 Oct;1180:36-46
pubmed: 19906259
Radiology. 1982 Apr;143(1):29-36
pubmed: 7063747
JAMA Neurol. 2019 Sep 1;76(9):1060-1069
pubmed: 31233127
Neurology. 2017 May 9;88(19):1788-1794
pubmed: 28404801
Sci Transl Med. 2020 Jan 1;12(524):
pubmed: 31894103
Neurology. 1984 Jul;34(7):939-44
pubmed: 6610841
J Alzheimers Dis. 2015;49(4):1105-14
pubmed: 26599049
Neurobiol Aging. 2018 Oct;70:233-241
pubmed: 30036759
F1000Res. 2013 Mar 04;2:71
pubmed: 26673949
Front Neuroinform. 2014 Jan 06;7:49
pubmed: 24432000
Nature. 2018 Feb 8;554(7691):249-254
pubmed: 29420472
J Alzheimers Dis. 2019;67(2):481-488
pubmed: 30594925
Hum Brain Mapp. 1996;4(1):58-73
pubmed: 20408186
EBioMedicine. 2015 Nov 22;3:135-140
pubmed: 26870824
Neurology. 2016 Oct 25;87(17):1827-1835
pubmed: 27694257
Lancet Neurol. 2020 May;19(5):422-433
pubmed: 32333900
Biomark Med. 2018 Jul;12(7):799-812
pubmed: 29902934
JAMA Neurol. 2020 Aug 1;77(8):955-965
pubmed: 32391858
Ann N Y Acad Sci. 2009 Oct;1180:47-55
pubmed: 19906260
Ann Neurol. 2018 Nov;84(5):648-658
pubmed: 30196548
Mol Psychiatry. 2021 Feb;26(2):429-442
pubmed: 33106600
Alzheimers Dement (Amst). 2018 Mar 06;10:245-252
pubmed: 29780869
Alzheimers Res Ther. 2013 Mar 28;5(2):9
pubmed: 23551972
Mult Scler. 2019 Apr;25(5):678-686
pubmed: 29542376