Roles of A-kinase Anchor Protein 12 in Astrocyte and Oligodendrocyte Precursor Cell in Postnatal Corpus Callosum.
A-kinase anchor protein 12
Astrocytes
Brain
Oligodendrocyte precursor cells
Postnatal development
White matter
Journal
Stem cell reviews and reports
ISSN: 2629-3277
Titre abrégé: Stem Cell Rev Rep
Pays: United States
ID NLM: 101752767
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
accepted:
05
01
2021
pubmed:
26
1
2021
medline:
4
3
2022
entrez:
25
1
2021
Statut:
ppublish
Résumé
The formation of the corpus callosum in the postnatal period is crucial for normal neurological function, and clinical genetic studies have identified an association of 6q24-25 microdeletion in this process. However, the mechanisms underlying corpus callosum formation and its critical gene(s) are not fully understood or identified. In this study, we examined the roles of AKAP12 in postnatal corpus callosum formation by focusing on the development of glial cells, because AKAP12 is coded on 6q25.1 and has recently been shown to play roles in the regulations of glial function. In mice, the levels of AKAP12 expression was confirmed to be larger in the corpus callosum compared to the cortex, and AKAP12 levels decreased with age both in the corpus callosum and cortex regions. In addition, astrocytes expressed AKAP12 in the corpus callosum after birth, but oligodendrocyte precursor cells (OPCs), another major type of glial cell in the developing corpus callosum, did not. Furthermore, compared to wild types, Akap12 knockout mice showed smaller numbers of both astrocytes and OPCs, along with slower development of corpus callosum after birth. These findings suggest that AKAP12 signaling may be required for postnatal glial formation in the corpus callosum through cell- and non-cell autonomous mechanisms.
Identifiants
pubmed: 33492625
doi: 10.1007/s12015-021-10118-w
pii: 10.1007/s12015-021-10118-w
pmc: PMC8310527
mid: NIHMS1698856
doi:
Substances chimiques
A Kinase Anchor Proteins
0
Akap12 protein, mouse
0
Cell Cycle Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1446-1455Subventions
Organisme : NINDS NIH HHS
ID : R01 NS065089
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS091573
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS113556
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG066478
Pays : United States
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.
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