Towards understanding antimicrobial activity, cytotoxicity and the mode of action of dichapetalins A and M using in silico and in vitro studies.

Africa Anti-Bacterial Agents / pharmacology Computer Simulation Humans Microbial Sensitivity Tests Plant Extracts / pharmacology Staphylococcus aureus
Bacteria Dichapetalin A Dichapetalin M Dichapetalum madagascariense MCF-7 PXR

Journal

Toxicon : official journal of the International Society on Toxinology
ISSN: 1879-3150
Titre abrégé: Toxicon
Pays: England
ID NLM: 1307333

Informations de publication

Date de publication:
15 Apr 2021
Historique:
received: 18 07 2020
revised: 01 01 2021
accepted: 10 01 2021
pubmed: 26 1 2021
medline: 13 5 2021
entrez: 25 1 2021
Statut: ppublish

Résumé

Dichapetalum madagascariense Poir (Dichapetalaceae) is traditionally used to treat bacterial infections, jaundice, urethritis and viral hepatitis in Africa. Its root contains a broad spectrum of biologically active dichapetalins. To evaluate the plant's effect on human MCF-7 cells and its' antibacterial and antiparasitic potentials, we isolated and identified the known dichapetalins A and M from the roots. Both dichapetalins were tested on six bacterial strains (Shigella flexneri, Bacillus cereus, Salmonella paratyphi B, Listeria monocytogenes, Escherichia coli, Staphylococcus aureus) and two parasite strains; Trypanosoma brucei brucei, and Leishmania donovani using the Alamar Blue assay system. Dichapetalins A and M were more potent against B. cereus with IC

Identifiants

DOI: 10.1016/j.toxicon.2021.01.002 PMID: 33493498
pubmed: 33493498
pii: S0041-0101(21)00018-0
doi: 10.1016/j.toxicon.2021.01.002
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Plant Extracts 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

28-37

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Auteurs

Mary Anti Chama (MA)

Department of Chemistry, School of Physical and Mathematical Sciences, University of Ghana, Ghana. Electronic address: machama@ug.edu.gh.

Dezso Modos (D)

Department of Chemistry, University of Cambridge, United Kingdom.

Lewis Howard Mervin (LH)

Department of Chemistry, University of Cambridge, United Kingdom.

Kofi Baffour-Awuah Owusu (KB)

Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Ghana.

Daniel Moscoh Ayine-Tora (DM)

School of Chemical Sciences, The University of Auckland, New Zealand.

Beverly Egyir (B)

Department of Bacteriology, Noguchi Memorial Institute for Medical Research, University of Ghana, Ghana.

Lily Paemka (L)

Department of Biochemistry Cell and Molecular Biology, University of Ghana, Ghana; West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Ghana.

George Yankson (G)

Department of Biochemistry Cell and Molecular Biology, University of Ghana, Ghana; West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Ghana.

Mitsuko Ohashi (M)

Department of Parasitology, Noguchi Memorial Institute for Medical Research, University of Ghana, Ghana.

Avid Muammar Afzal (AM)

Department of Chemistry, University of Cambridge, United Kingdom.

Andreas Bender (A)

Department of Chemistry, University of Cambridge, United Kingdom.

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Classifications MeSH

questionsmedicales.fr › Régions géographiques › Afrique › Towards understanding antimicrobial activity,...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Towards understanding antimicrobial activity,...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Towards understanding antimicrobial activity,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Towards understanding antimicrobial activity,...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Towards understanding antimicrobial activity,...
questionsmedicales.fr › Préparations pharmaceutiques › Extraits de plantes › Towards understanding antimicrobial activity,...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Towards understanding antimicrobial activity,...