Galanin promotes autophagy and alleviates apoptosis in the hypertrophied heart through FoxO1 pathway.
Apoptosis
Autophagy
Cardiac remodeling
Galanin
Hypertrophy
Metabolism
Journal
Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
09
12
2020
revised:
10
01
2021
accepted:
11
01
2021
pubmed:
26
1
2021
medline:
22
6
2021
entrez:
25
1
2021
Statut:
ppublish
Résumé
Autophagy and apoptosis are powerful regulators of multiple facets of cellular metabolism and homeostasis. Here, we uncover that galanin, a pleiotropic peptide, regulates cardiac autophagy and deactivates apoptotic cell death through the Forkhead box protein O1 (FoxO1) pathway. In hypertrophied heart, galanin promotes autophagy and metabolic shift from fatty acid (FA) to glucose oxidation and preserves mitochondrial integrity. In cardiomyoblasts, galanin triggers autophagosome formation and alleviates hypertrophy, apoptotic cell death, and mitochondrial stress. Mechanistically, galanin dictates cell autophagic and anti-apoptotic phenotypes through FoxO1 pathway. Together, these findings uncover a previously unknown role for galanin in the regulation of cardiac autophagy and provide new insights into the molecular mechanisms supporting cell survival in the hypertrophic reprogramming of the heart.
Identifiants
pubmed: 33493902
pii: S2213-2317(21)00014-8
doi: 10.1016/j.redox.2021.101866
pmc: PMC7823211
pii:
doi:
Substances chimiques
FOXO1 protein, human
0
Forkhead Box Protein O1
0
Galanin
88813-36-9
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101866Informations de copyright
Copyright © 2021. Published by Elsevier B.V.