Concentration-Dependent Type 1 Interferon-Induced Regulation of MX1 and FABP3 in Bovine Endometrial Explants.
3R principle
cattle
embryo–maternal communication
endometrial explant model
interferon stimulated gene (ISG)
interferon α
interferon τ
subfertility
type 1 interferon receptor subunits 1/2 (IFNAR1/2)
type 1 interferon signaling
Journal
Animals : an open access journal from MDPI
ISSN: 2076-2615
Titre abrégé: Animals (Basel)
Pays: Switzerland
ID NLM: 101635614
Informations de publication
Date de publication:
21 Jan 2021
21 Jan 2021
Historique:
received:
20
12
2020
revised:
13
01
2021
accepted:
19
01
2021
entrez:
26
1
2021
pubmed:
27
1
2021
medline:
27
1
2021
Statut:
epublish
Résumé
The inadequate maternal recognition of embryonic interferon τ (IFNτ) might explain subfertility in cattle. This study aimed at modeling the inducibility of type 1 interferon receptor subunits 1/2 (IFNAR1/2), mimicking competition between IFNτ and infection-associated interferon α (IFNα), and simulating type 1 interferon pathways in vitro. Endometrial explants (n = 728 from n = 26 healthy uteri) were collected at the abattoir, challenged with IFNτ and/or IFNα in different concentrations, and incubated for 24 h. Gene expression analysis confirmed the inducibility of IFNAR1/2 within this model, it being most prominent in IFNAR2 with 10 ng/mL IFNα (
Identifiants
pubmed: 33494350
pii: ani11020262
doi: 10.3390/ani11020262
pmc: PMC7912598
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Ludwig-Maximilians-Universität München
ID : Faculty of Veterinary Medicine, 08LMU Mentoring Program for Young Scientists and VET Research Program 2018, 2019 and 2020
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