Cannabinoid and Cannabinoid-Related Receptors in the Myenteric Plexus of the Porcine Ileum.
5-HT1aR
CB1R
CB2R
TRPA1
TRPV1
endocannabinoid system
enteric nervous system
immunohistochemistry
pig
Journal
Animals : an open access journal from MDPI
ISSN: 2076-2615
Titre abrégé: Animals (Basel)
Pays: Switzerland
ID NLM: 101635614
Informations de publication
Date de publication:
21 Jan 2021
21 Jan 2021
Historique:
received:
29
12
2020
revised:
16
01
2021
accepted:
19
01
2021
entrez:
26
1
2021
pubmed:
27
1
2021
medline:
27
1
2021
Statut:
epublish
Résumé
An important piece of evidence has shown that molecules acting on cannabinoid receptors influence gastrointestinal motility and induce beneficial effects on gastrointestinal inflammation and visceral pain. The aim of this investigation was to immunohistochemically localize the distribution of canonical cannabinoid receptor type 1 (CB1R) and type 2 (CB2R) and the cannabinoid-related receptors transient potential vanilloid receptor 1 (TRPV1), transient potential ankyrin receptor 1 (TRPA1), and serotonin receptor 5-HT1a (5-HT1aR) in the myenteric plexus (MP) of pig ileum. CB1R, TRPV1, TRPA1, and 5-HT1aR were expressed, with different intensities in the cytoplasm of MP neurons. For each receptor, the proportions of the immunoreactive neurons were evaluated using the anti-HuC/HuD antibody. These receptors were also localized on nerve fibers (CB1R, TRPA1), smooth muscle cells of
Identifiants
pubmed: 33494452
pii: ani11020263
doi: 10.3390/ani11020263
pmc: PMC7912003
pii:
doi:
Types de publication
Journal Article
Langues
eng
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