Comparative Pharmacodynamics of Echinocandins against Aspergillus fumigatus Using an

Anidulafungin Antifungal Agents / pharmacology Aspergillus fumigatus Caspofungin Echinocandins / pharmacology Humans Lipopeptides Microbial Sensitivity Tests
antifungal agents aspergillosis dose optimization echinocandin in vitro PK/PD model pharmacodynamics

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
18 03 2021
Historique:
received: 25 07 2020
accepted: 17 01 2021
pubmed: 27 1 2021
medline: 22 6 2021
entrez: 26 1 2021
Statut: epublish

Résumé

Echinocandins have been used as primary therapy of invasive aspergillosis (IA), with suboptimal results at standard dosing. Here, we explored the efficacy of dose escalation in a validated

Identifiants

DOI: 10.1128/AAC.01618-20 PMID: 33495222 PMC: PMC8097425
pubmed: 33495222
pii: AAC.01618-20
doi: 10.1128/AAC.01618-20
pmc: PMC8097425
pii:
doi:

Substances chimiques

Antifungal Agents 0
Echinocandins 0
Lipopeptides 0
Anidulafungin 9HLM53094I
Caspofungin F0XDI6ZL63

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2021 American Society for Microbiology.

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Auteurs

Maria Siopi (M)

Clinical Microbiology Laboratory, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

David S Perlin (DS)

Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.

Maiken C Arendrup (MC)

Unit of Mycology, Statens Serum Institut, Copenhagen, Denmark.
Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Department of Clinical Microbiology, University of Copenhagen, Copenhagen, Denmark.
ORCID: 0000-0002-4747-0144

Spyros Pournaras (S)

Clinical Microbiology Laboratory, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.

Joseph Meletiadis (J)

Clinical Microbiology Laboratory, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece jmeletiadis@med.uoa.gr.
ORCID: 0000-0002-8869-1509

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides cycliques › Échinocandines › Anidulafungine › Comparative Pharmacodynamics of Echinocandins...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antifongiques › Comparative Pharmacodynamics of Echinocandins...
questionsmedicales.fr › Eucaryotes › Champignons › Deuteromycota › Aspergillus › Aspergillus fumigatus › Comparative Pharmacodynamics of Echinocandins...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides cycliques › Échinocandines › Caspofungine › Comparative Pharmacodynamics of Echinocandins...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides cycliques › Échinocandines › Comparative Pharmacodynamics of Echinocandins...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Comparative Pharmacodynamics of Echinocandins...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Lipopeptides › Comparative Pharmacodynamics of Echinocandins...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Comparative Pharmacodynamics of Echinocandins...