Unique structural solution from a V
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
25 01 2021
25 01 2021
Historique:
received:
19
05
2020
accepted:
10
12
2020
entrez:
26
1
2021
pubmed:
27
1
2021
medline:
9
2
2021
Statut:
epublish
Résumé
Broadly neutralizing antibodies (bnAbs) targeting conserved influenza A virus (IAV) hemagglutinin (HA) epitopes can provide valuable information for accelerating universal vaccine designs. Here, we report structural details for heterosubtypic recognition of HA from circulating and emerging IAVs by the human antibody 3I14. Somatic hypermutations play a critical role in shaping the HCDR3, which alone and uniquely among V
Identifiants
pubmed: 33495478
doi: 10.1038/s41467-020-20879-6
pii: 10.1038/s41467-020-20879-6
pmc: PMC7835374
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
Epitopes
0
Hemagglutinin Glycoproteins, Influenza Virus
0
Influenza Vaccines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
559Subventions
Organisme : NIAID NIH HHS
ID : R01 AI121285
Pays : United States
Organisme : NIH HHS
ID : S10 OD012289
Pays : United States
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