Naturalizing mouse models for immunology.
Journal
Nature immunology
ISSN: 1529-2916
Titre abrégé: Nat Immunol
Pays: United States
ID NLM: 100941354
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
04
09
2020
accepted:
07
12
2020
entrez:
26
1
2021
pubmed:
27
1
2021
medline:
7
4
2021
Statut:
ppublish
Résumé
Laboratory mice have provided invaluable insight into mammalian immune systems. Yet the immune phenotypes of mice bred and maintained in conventional laboratory conditions often differ from the immune phenotypes of wild mammals. Recent work to naturalize the environmental experience of inbred laboratory mice-to take them where the wild things are (to borrow a phrase from Maurice Sendak), via approaches such as construction of exposure histories, provision of fecal transplants or surrogate mothering by wild mice, and rewilding-is poised to expand understanding, complementing genetic and phylogenetic research on how natural selection has shaped mammalian immune systems while improving the translational potential of mouse research.
Identifiants
pubmed: 33495644
doi: 10.1038/s41590-020-00857-2
pii: 10.1038/s41590-020-00857-2
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111-117Références
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