Dose-response relationship between genetically proxied average blood glucose levels and incident coronary heart disease in individuals without diabetes mellitus.
Adult
Aged
Biomarkers
/ blood
Blood Glucose
/ metabolism
Coronary Disease
/ blood
Female
Genetic Predisposition to Disease
Glycated Hemoglobin
/ metabolism
Humans
Incidence
Male
Mendelian Randomization Analysis
Middle Aged
Phenotype
Polymorphism, Single Nucleotide
Time Factors
United Kingdom
/ epidemiology
Average blood glucose levels
CHD
Mendelian randomisation
Journal
Diabetologia
ISSN: 1432-0428
Titre abrégé: Diabetologia
Pays: Germany
ID NLM: 0006777
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
25
09
2020
accepted:
19
11
2020
pubmed:
27
1
2021
medline:
16
2
2022
entrez:
26
1
2021
Statut:
ppublish
Résumé
Our aim was to investigate the relationship between average blood glucose levels and incident CHD in individuals without diabetes mellitus. To investigate average blood glucose levels, we studied HbA Every one mmol/mol increase in genetically proxied HbA In individuals without diabetes mellitus, lowering average blood glucose levels may reduce CHD risk in a dose-dependent way.
Identifiants
pubmed: 33495845
doi: 10.1007/s00125-020-05377-0
pii: 10.1007/s00125-020-05377-0
pmc: PMC7940279
doi:
Substances chimiques
Biomarkers
0
Blood Glucose
0
Glycated Hemoglobin A
0
hemoglobin A1c protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
845-849Subventions
Organisme : Wellcome Trust
ID : 204623/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00002/7
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RE/18/4/34215
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Références
Epidemiology. 2014 Nov;25(6):877-85
pubmed: 25166881
Arch Intern Med. 2004 Oct 25;164(19):2147-55
pubmed: 15505129
PLoS Med. 2017 Sep 12;14(9):e1002383
pubmed: 28898252
N Engl J Med. 2008 Jun 12;358(24):2545-59
pubmed: 18539917
Lancet Diabetes Endocrinol. 2019 Oct;7(10):776-785
pubmed: 31422062
Nat Commun. 2015 May 28;6:7060
pubmed: 26017687
N Engl J Med. 2008 Jun 12;358(24):2560-72
pubmed: 18539916
BMJ. 2020 Jul 15;370:m2297
pubmed: 32669282
J Am Coll Cardiol. 2017 Jul 4;70(1):1-25
pubmed: 28527533
Stat Med. 2016 May 20;35(11):1880-906
pubmed: 26661904
Nat Genet. 2020 Jul;52(7):680-691
pubmed: 32541925