Caveolin-1 and cavin1 act synergistically to generate a unique lipid environment in caveolae.
Journal
The Journal of cell biology
ISSN: 1540-8140
Titre abrégé: J Cell Biol
Pays: United States
ID NLM: 0375356
Informations de publication
Date de publication:
01 03 2021
01 03 2021
Historique:
received:
19
05
2020
revised:
20
11
2020
accepted:
21
12
2020
entrez:
26
1
2021
pubmed:
27
1
2021
medline:
10
9
2021
Statut:
ppublish
Résumé
Caveolae are specialized domains of the vertebrate cell surface with a well-defined morphology and crucial roles in cell migration and mechanoprotection. Unique compositions of proteins and lipids determine membrane architectures. The precise caveolar lipid profile and the roles of the major caveolar structural proteins, caveolins and cavins, in selectively sorting lipids have not been defined. Here, we used quantitative nanoscale lipid mapping together with molecular dynamic simulations to define the caveolar lipid profile. We show that caveolin-1 (CAV1) and cavin1 individually sort distinct plasma membrane lipids. Intact caveolar structures composed of both CAV1 and cavin1 further generate a unique lipid nano-environment. The caveolar lipid sorting capability includes selectivities for lipid headgroups and acyl chains. Because lipid headgroup metabolism and acyl chain remodeling are tightly regulated, this selective lipid sorting may allow caveolae to act as transit hubs to direct communications among lipid metabolism, vesicular trafficking, and signaling.
Identifiants
pubmed: 33496726
pii: 211716
doi: 10.1083/jcb.202005138
pmc: PMC7844427
pii:
doi:
Substances chimiques
CAV1 protein, human
0
Caveolin 1
0
Lipids
0
Mutant Proteins
0
Phosphatidylserines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM124233
Pays : United States
Informations de copyright
© 2021 Zhou et al.
Références
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15500-5
pubmed: 16223883
Elife. 2013 Sep 24;2:e00905
pubmed: 24069528
Dev Cell. 2012 Jul 17;23(1):11-20
pubmed: 22814599
J Cell Biol. 2016 Sep 26;214(7):847-58
pubmed: 27646276
J Cell Biol. 1994 Jul;126(1):111-26
pubmed: 7517942
Eur J Biochem. 2004 May;271(10):2028-36
pubmed: 15128312
Annu Rev Cell Dev Biol. 2018 Oct 6;34:111-136
pubmed: 30296391
Science. 2015 Aug 21;349(6250):873-6
pubmed: 26293964
J Biol Chem. 1997 Mar 14;272(11):7381-9
pubmed: 9054438
Proc Natl Acad Sci U S A. 1995 Oct 24;92(22):10339-43
pubmed: 7479780
EMBO J. 2009 Apr 22;28(8):1001-15
pubmed: 19262564
J Chem Theory Comput. 2008 May;4(5):819-34
pubmed: 26621095
Dev Cell. 2015 Nov 23;35(4):513-25
pubmed: 26585296
Dev Cell. 2014 Nov 24;31(4):405-19
pubmed: 25453557
Genomics. 1999 Apr 1;57(1):120-9
pubmed: 10191091
J Mol Graph. 1996 Feb;14(1):33-8, 27-8
pubmed: 8744570
Mol Biol Cell. 2005 Apr;16(4):2091-105
pubmed: 15689493
Proc Natl Acad Sci U S A. 1987 Nov;84(22):7957-61
pubmed: 2446314
Nat Med. 2000 Dec;6(12):1362-7
pubmed: 11100121
Genes Cells. 2012 Aug;17(8):728-36
pubmed: 22747682
Trends Cell Biol. 2012 Jul;22(7):381-9
pubmed: 22613354
Mol Biol Cell. 2004 Jul;15(7):3114-22
pubmed: 15107466
J Cell Sci. 2015 Aug 1;128(15):2747-58
pubmed: 26159735
J Biol Chem. 1997 Oct 10;272(41):25437-40
pubmed: 9325253
Nat Commun. 2019 Jul 22;10(1):3279
pubmed: 31332168
J Biol Chem. 2015 Oct 9;290(41):24875-90
pubmed: 26304117
Cell. 2017 Jan 12;168(1-2):239-251.e16
pubmed: 28041850
J Biol Chem. 2017 Aug 25;292(34):14292-14307
pubmed: 28698382
Cell. 2011 Feb 4;144(3):402-13
pubmed: 21295700
J Mol Biol. 2005 Jan 14;345(2):339-50
pubmed: 15571726
Nat Cell Biol. 2009 Jul;11(7):807-14
pubmed: 19525939
EMBO J. 1993 Apr;12(4):1597-605
pubmed: 8385608
J Cell Biol. 2015 Oct 12;211(1):53-61
pubmed: 26459598
Nat Commun. 2015 Apr 21;6:6867
pubmed: 25897946
Cell. 2008 Jan 11;132(1):113-24
pubmed: 18191225
J Cell Biol. 2003 Jan 20;160(2):165-70
pubmed: 12527752
Nature. 1982 Apr 15;296(5858):651-3
pubmed: 7070509
Mol Biol Cell. 2015 Oct 15;26(20):3561-9
pubmed: 26269585
Nat Commun. 2017 Feb 09;8:14492
pubmed: 28181515
PLoS One. 2012;7(4):e34516
pubmed: 22493697
J Biol Chem. 2002 Feb 8;277(6):4277-84
pubmed: 11729179
Biochemistry. 2003 Jan 14;42(1):42-56
pubmed: 12515538
Life Sci Alliance. 2019 Jul 11;2(4):
pubmed: 31296567
PLoS Biol. 2014 Apr 08;12(4):e1001832
pubmed: 24714042
J Biol Chem. 2008 May 23;283(21):14610-8
pubmed: 18353778
J Chem Theory Comput. 2015 May 12;11(5):2144-55
pubmed: 26574417
Cell. 2015 Apr 23;161(3):581-594
pubmed: 25910209
J Cell Biol. 2020 Apr 6;219(4):
pubmed: 32328645
Nat Commun. 2013;4:1831
pubmed: 23652019
Nat Biotechnol. 2007 Mar;25(3):327-37
pubmed: 17334358
Trends Endocrinol Metab. 2011 Aug;22(8):318-24
pubmed: 21592817
Mol Cell Biol. 2014 Mar;34(5):862-76
pubmed: 24366544
Cell Metab. 2008 Oct;8(4):310-7
pubmed: 18840361
Nat Commun. 2014 Dec 09;5:5647
pubmed: 25487648
J Cell Sci. 2015 Apr 1;128(7):1269-78
pubmed: 25829513
Elife. 2013 Jan 01;3:e01434
pubmed: 24473072
Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9256-61
pubmed: 19470488
J Clin Invest. 2006 May;116(5):1284-91
pubmed: 16670769
J Cell Biol. 2009 Jun 29;185(7):1259-73
pubmed: 19546242
Elife. 2020 May 04;9:
pubmed: 32364496
Sci Rep. 2019 Jul 8;9(1):9888
pubmed: 31285524
J Cell Biol. 2014 Mar 3;204(5):777-92
pubmed: 24567358
Dev Cell. 2020 Jul 6;54(1):75-91.e7
pubmed: 32485139
EMBO Rep. 2018 Sep;19(9):
pubmed: 30021837
Cell. 1992 Feb 21;68(4):673-82
pubmed: 1739974
J Histochem Cytochem. 1994 Feb;42(2):155-66
pubmed: 8288861
PLoS One. 2012;7(9):e44879
pubmed: 23028656
J Phys Chem B. 2007 Jul 12;111(27):7812-24
pubmed: 17569554
J Chem Theory Comput. 2013 Jan 8;9(1):687-97
pubmed: 26589065
J Cell Biol. 1992 Sep;118(5):1003-14
pubmed: 1512286