Radiosynthesis,


Journal

ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337

Informations de publication

Date de publication:
17 02 2021
Historique:
pubmed: 27 1 2021
medline: 22 6 2021
entrez: 26 1 2021
Statut: ppublish

Résumé

CBD-2115 was selected from a library of 148 compounds based on a pyridinyl-indole scaffold as a first-in-class 4R-tau radiotracer. In vitro binding assays showed [

Identifiants

pubmed: 33497190
doi: 10.1021/acschemneuro.0c00801
pmc: PMC9350900
mid: NIHMS1795861
doi:

Substances chimiques

Radiopharmaceuticals 0
tau Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

596-602

Subventions

Organisme : NIA NIH HHS
ID : R01 AG052414
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054473
Pays : United States
Organisme : NINDS NIH HHS
ID : U19 NS110456
Pays : United States

Références

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Auteurs

Anton Lindberg (A)

Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.

Ashley C Knight (AC)

Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.
Department of Psychiatry/Institute of Medical Science, University of Toronto, Toronto, ON M5T 1R8, Canada.

Daniel Sohn (D)

CBD Solutions, Center for Molecular Medicine, Karolinska Hospital, SE-17176 Stockholm, Sweden.
Novandi Chemistry AB, SE-15136 Södertälje, Sweden.

Laszlo Rakos (L)

CBD Solutions, Center for Molecular Medicine, Karolinska Hospital, SE-17176 Stockholm, Sweden.
Novandi Chemistry AB, SE-15136 Södertälje, Sweden.

Junchao Tong (J)

Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.

April Radelet (A)

Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States.

N Scott Mason (NS)

Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States.

Jeffrey S Stehouwer (JS)

Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States.

Brian J Lopresti (BJ)

Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States.

William E Klunk (WE)

Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States.

Johan Sandell (J)

Novandi Chemistry AB, SE-15136 Södertälje, Sweden.

Alexander Sandberg (A)

Department of Physics, Chemistry and Biology, Linköping University, SE-58183 Linköping, Sweden.

Per Hammarström (P)

Department of Physics, Chemistry and Biology, Linköping University, SE-58183 Linköping, Sweden.

Samuel Svensson (S)

CBD Solutions, Center for Molecular Medicine, Karolinska Hospital, SE-17176 Stockholm, Sweden.
Department of Physics, Chemistry and Biology, Linköping University, SE-58183 Linköping, Sweden.

Chester A Mathis (CA)

Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States.

Neil Vasdev (N)

Azrieli Centre for Neuro-Radiochemistry, Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada.
Department of Psychiatry/Institute of Medical Science, University of Toronto, Toronto, ON M5T 1R8, Canada.

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Classifications MeSH