Importance of Cx43 for Right Ventricular Function.
connexin
mitochondria
pulmonary hypertension
right ventricle
tetralogy of fallot
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 Jan 2021
20 Jan 2021
Historique:
received:
21
12
2020
revised:
13
01
2021
accepted:
18
01
2021
entrez:
27
1
2021
pubmed:
28
1
2021
medline:
10
4
2021
Statut:
epublish
Résumé
In the heart, connexins form gap junctions, hemichannels, and are also present within mitochondria, with connexin 43 (Cx43) being the most prominent connexin in the ventricles. Whereas the role of Cx43 is well established for the healthy and diseased left ventricle, less is known about the importance of Cx43 for the development of right ventricular (RV) dysfunction. The present article focusses on the importance of Cx43 for the developing heart. Furthermore, we discuss the expression and localization of Cx43 in the diseased RV, i.e., in the tetralogy of Fallot and in pulmonary hypertension, in which the RV is affected, and RV hypertrophy and failure occur. We will also introduce other Cx molecules that are expressed in RV and surrounding tissues and have been reported to be involved in RV pathophysiology. Finally, we highlight therapeutic strategies aiming to improve RV function in pulmonary hypertension that are associated with alterations of Cx43 expression and function.
Identifiants
pubmed: 33498172
pii: ijms22030987
doi: 10.3390/ijms22030987
pmc: PMC7863922
pii:
doi:
Substances chimiques
Connexin 43
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : project number 268555672 - SFB 1213, projects A06, B05, and Bo 2955-4/1
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