Adjuvant Selection for Influenza and RSV Prefusion Subunit Vaccines.
RSV
adjuvant
influenza
microbiology
vaccine
virology
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
20 Jan 2021
20 Jan 2021
Historique:
received:
31
12
2020
revised:
17
01
2021
accepted:
18
01
2021
entrez:
27
1
2021
pubmed:
28
1
2021
medline:
28
1
2021
Statut:
epublish
Résumé
Subunit vaccines exhibit favorable safety and immunogenicity profiles and can be designed to mimic native antigen structures. However, pairing with an appropriate adjuvant is imperative in order to elicit effective humoral and cellular immune responses. In this study, we aimed to determine an optimal adjuvant pairing with the prefusion form of influenza haemagglutinin (HA) or respiratory syncytial virus (RSV) fusion (F) subunit vaccines in BALB/c mice in order to inform future subunit vaccine adjuvant selection. We tested a panel of adjuvants, including aluminum hydroxide (alhydrogel), QS21, Addavax, Addavax with QS21 (AdQS21), and Army Liposome Formulation 55 with monophosphoryl lipid A and QS21 (ALF55). We found that all adjuvants elicited robust humoral responses in comparison to placebo, with the induction of potent neutralizing antibodies observed in all adjuvanted groups against influenza and in AdQS21, alhydrogel, and ALF55 against RSV. Upon HA vaccination, we observed that none of the adjuvants were able to significantly increase the frequency of CD4
Identifiants
pubmed: 33498370
pii: vaccines9020071
doi: 10.3390/vaccines9020071
pmc: PMC7909420
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : National Health and Medical Research Council
ID : APP1144025
Organisme : National Health and Medical Research Council
ID : APP1125107
Références
Nat Med. 2014 Feb;20(2):143-51
pubmed: 24412922
Mucosal Immunol. 2018 May;11(3):668-680
pubmed: 29186108
Immunol Rev. 2006 Jun;211:146-53
pubmed: 16824124
Science. 2011 Aug 12;333(6044):850-6
pubmed: 21798894
J Clin Microbiol. 1988 Aug;26(8):1595-7
pubmed: 2459154
Eur J Immunol. 2012 Oct;42(10):2709-19
pubmed: 22777876
J Infect Dis. 1977 Nov;136(5):623-32
pubmed: 335000
Immunol Lett. 2006 Jan 15;102(1):10-5
pubmed: 16188325
J Infect Dis. 2016 Sep 15;214(6):945-52
pubmed: 27354365
Vaccine. 1995 Jan;13(1):41-4
pubmed: 7762276
Annu Rev Biochem. 1998;67:227-64
pubmed: 9759489
Semin Immunol. 2018 Oct;39:14-21
pubmed: 29801750
J Immunol. 2011 Dec 1;187(11):5510-4
pubmed: 22058417
J Immunol. 2004 May 1;172(9):5598-605
pubmed: 15100303
Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3089-94
pubmed: 22323598
Clin Exp Immunol. 1977 Apr;28(1):19-26
pubmed: 862248
Sci Rep. 2016 Mar 07;6:22666
pubmed: 26947245
Immunol Cell Biol. 2016 Nov;94(10):949-954
pubmed: 27502143
J Immunol. 1979 Jun;122(6):2521-6
pubmed: 571890
Front Immunol. 2019 Jun 25;10:1457
pubmed: 31316510
Expert Rev Vaccines. 2017 Jan;16(1):55-63
pubmed: 27448771
Clin Vaccine Immunol. 2011 Feb;18(2):289-97
pubmed: 21159923
Vaccine. 2012 Nov 19;30(49):6971-9
pubmed: 23041122
NPJ Vaccines. 2017 Sep 8;2:25
pubmed: 29263880
Sci Rep. 2019 Apr 5;9(1):5661
pubmed: 30952887
J Pharm Sci. 2005 Nov;94(11):2510-9
pubmed: 16200615
ChemMedChem. 2013 Mar;8(3):360-76
pubmed: 23316023
J Virol. 2010 Nov;84(22):12011-7
pubmed: 20844030
Expert Opin Biol Ther. 2004 Jul;4(7):1129-38
pubmed: 15268679
Acta Naturae. 2019 Oct-Dec;11(4):22-32
pubmed: 31993232
Hum Vaccin Immunother. 2017 Jan 2;13(1):19-33
pubmed: 27636098
Proc Natl Acad Sci U S A. 2012 Sep 18;109(38):E2551-60
pubmed: 22927425
Proc Natl Acad Sci U S A. 2005 May 17;102(20):7239-44
pubmed: 15872023
PLoS One. 2015 Apr 09;10(4):e0124082
pubmed: 25856628
Ther Adv Vaccines. 2013 May;1(1):7-20
pubmed: 24757512
J Clin Microbiol. 1989 Mar;27(3):589-92
pubmed: 2715331
Cell Mol Immunol. 2016 Mar;13(2):180-90
pubmed: 25640653
Nat Rev Immunol. 2008 Apr;8(4):247-58
pubmed: 18323851
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):125-30
pubmed: 24344259
Clin Microbiol Rev. 2013 Jul;26(3):476-92
pubmed: 23824369
J Med Virol. 1980;6(3):203-11
pubmed: 7229627
Front Immunol. 2020 Nov 04;11:592370
pubmed: 33250897
Oncotarget. 2016 Jun 28;7(26):39171-39183
pubmed: 27322555
Expert Opin Biol Ther. 2018 Jan;18(1):1-5
pubmed: 29047305
Vaccine. 2008 Jun 19;26(26):3209-22
pubmed: 18462843
J Immunol. 2013 Sep 1;191(5):2486-94
pubmed: 23885108
Nat Commun. 2015 May 13;6:6833
pubmed: 25967273
J Immunol. 2009 Nov 15;183(10):6186-97
pubmed: 19864596
Lancet Infect Dis. 2012 Jan;12(1):36-44
pubmed: 22032844
Curr Opin Immunol. 2014 Jun;28:1-5
pubmed: 24463269
Expert Rev Vaccines. 2007 Oct;6(5):699-710
pubmed: 17931151
Expert Rev Vaccines. 2007 Oct;6(5):723-39
pubmed: 17931153
BMC Immunol. 2018 Jan 31;19(1):6
pubmed: 29386070
Expert Rev Vaccines. 2013 Jan;12(1):13-30
pubmed: 23256736
Infect Immun. 1978 Jun;20(3):640-5
pubmed: 669816
J Clin Invest. 2016 Feb;126(2):605-10
pubmed: 26731473
J Virol. 2018 Jun 13;92(13):
pubmed: 29669838
Proc Natl Acad Sci U S A. 1979 Sep;76(9):4622-6
pubmed: 291990
Nature. 2020 Oct;586(7830):516-527
pubmed: 32967006
Vaccines (Basel). 2020 May 27;8(2):
pubmed: 32471056
Blood. 2004 Jul 15;104(2):487-94
pubmed: 15059848
ACS Nano. 2008 Feb;2(2):281-6
pubmed: 19206628
Microbiol Immunol. 2007;51(11):1099-107
pubmed: 18037787
Clin Vaccine Immunol. 2015 Dec 16;23(3):189-95
pubmed: 26677198
J Virol. 2014 Feb;88(3):1684-93
pubmed: 24257602
J Pharm Sci. 2016 Jun;105(6):1829-1836
pubmed: 27238481
Vaccine. 2012 Mar 16;30(13):2256-72
pubmed: 22306376
Front Immunol. 2018 Feb 16;9:276
pubmed: 29503649
Eur J Immunol. 2008 Aug;38(8):2068-71
pubmed: 18651701
Expert Rev Vaccines. 2012 Mar;11(3):349-66
pubmed: 22380826
Nat Med. 2013 Dec;19(12):1597-608
pubmed: 24309663
Adv Drug Deliv Rev. 1998 Jul 6;32(3):155-172
pubmed: 10837642
Cell Mol Life Sci. 2008 Oct;65(20):3231-40
pubmed: 18668203
mBio. 2012 Aug 07;3(4):
pubmed: 22872782
Sci Rep. 2016 Jan 21;6:19570
pubmed: 26791076
Sci Transl Med. 2015 Sep 9;7(304):304ra142
pubmed: 26355031
Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5992-7
pubmed: 24711420
J Pharm Sci. 2011 Aug;100(8):3245-3250
pubmed: 21425166
Cell. 2019 May 16;177(5):1124-1135.e16
pubmed: 31100267
Front Immunol. 2018 Mar 23;9:600
pubmed: 29628926
J Virol. 2002 Sep;76(17):8729-36
pubmed: 12163593
Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1049-54
pubmed: 24395804
Front Immunol. 2019 Mar 22;10:548
pubmed: 30967872
Sci Rep. 2020 Dec 16;10(1):22077
pubmed: 33328567
J Immunol. 2007 Feb 15;178(4):2370-9
pubmed: 17277143