GENERATOR Breast DataMart-The Novel Breast Cancer Data Discovery System for Research and Monitoring: Preliminary Results and Future Perspectives.

DataMart breast cancer healthcare predictive model real world data

Journal

Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269

Informations de publication

Date de publication:
22 Jan 2021
Historique:
received: 30 12 2020
revised: 18 01 2021
accepted: 20 01 2021
entrez: 27 1 2021
pubmed: 28 1 2021
medline: 28 1 2021
Statut: epublish

Résumé

Artificial Intelligence (AI) is increasingly used for process management in daily life. In the medical field AI is becoming part of computerized systems to manage information and encourage the generation of evidence. Here we present the development of the application of AI to IT systems present in the hospital, for the creation of a DataMart for the management of clinical and research processes in the field of breast cancer. A multidisciplinary team of radiation oncologists, epidemiologists, medical oncologists, breast surgeons, data scientists, and data management experts worked together to identify relevant data and sources located inside the hospital system. Combinations of open-source data science packages and industry solutions were used to design the target framework. To validate the DataMart directly on real-life cases, the working team defined tumoral pathology and clinical purposes of proof of concepts (PoCs). Data were classified into "Not organized, not 'ontologized' data", "Organized, not 'ontologized' data", and "Organized and 'ontologized' data". Archives of real-world data (RWD) identified were platform based on ontology, hospital data warehouse, PDF documents, and electronic reports. Data extraction was performed by direct connection with structured data or text-mining technology. Two PoCs were performed, by which waiting time interval for radiotherapy and performance index of breast unit were tested and resulted available. GENERATOR Breast DataMart was created for supporting breast cancer pathways of care. An AI-based process automatically extracts data from different sources and uses them for generating trend studies and clinical evidence. Further studies and more proof of concepts are needed to exploit all the potentials of this system.

Sections du résumé

BACKGROUND BACKGROUND
Artificial Intelligence (AI) is increasingly used for process management in daily life. In the medical field AI is becoming part of computerized systems to manage information and encourage the generation of evidence. Here we present the development of the application of AI to IT systems present in the hospital, for the creation of a DataMart for the management of clinical and research processes in the field of breast cancer.
MATERIALS AND METHODS METHODS
A multidisciplinary team of radiation oncologists, epidemiologists, medical oncologists, breast surgeons, data scientists, and data management experts worked together to identify relevant data and sources located inside the hospital system. Combinations of open-source data science packages and industry solutions were used to design the target framework. To validate the DataMart directly on real-life cases, the working team defined tumoral pathology and clinical purposes of proof of concepts (PoCs).
RESULTS RESULTS
Data were classified into "Not organized, not 'ontologized' data", "Organized, not 'ontologized' data", and "Organized and 'ontologized' data". Archives of real-world data (RWD) identified were platform based on ontology, hospital data warehouse, PDF documents, and electronic reports. Data extraction was performed by direct connection with structured data or text-mining technology. Two PoCs were performed, by which waiting time interval for radiotherapy and performance index of breast unit were tested and resulted available.
CONCLUSIONS CONCLUSIONS
GENERATOR Breast DataMart was created for supporting breast cancer pathways of care. An AI-based process automatically extracts data from different sources and uses them for generating trend studies and clinical evidence. Further studies and more proof of concepts are needed to exploit all the potentials of this system.

Identifiants

pubmed: 33498985
pii: jpm11020065
doi: 10.3390/jpm11020065
pmc: PMC7911086
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Fabio Marazzi (F)

Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, UOC di Radioterapia Oncologica, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, 00186 Rome, Italy.

Luca Tagliaferri (L)

Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, UOC di Radioterapia Oncologica, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, 00186 Rome, Italy.

Valeria Masiello (V)

Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, UOC di Radioterapia Oncologica, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, 00186 Rome, Italy.

Francesca Moschella (F)

Dipartimento di Scienze della Salute della Donna e del Bambino e di Sanità Pubblica, UOC di Chirurgia Senologica, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, 00186 Roma, Italy.

Giuseppe Ferdinando Colloca (GF)

Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, UOC di Radioterapia Oncologica, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, 00186 Rome, Italy.

Barbara Corvari (B)

Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, UOC di Radioterapia Oncologica, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, 00186 Rome, Italy.

Alejandro Martin Sanchez (AM)

Dipartimento di Scienze della Salute della Donna e del Bambino e di Sanità Pubblica, UOC di Chirurgia Senologica, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, 00186 Roma, Italy.

Nikola Dino Capocchiano (ND)

Istituto di Radiologia, Università Cattolica del Sacro Cuore, 00186 Rome, Italy.

Roberta Pastorino (R)

Fondazione Policlinico Universitario "A. Gemelli" IRCCS, 00186 Roma, Italy.

Chiara Iacomini (C)

Fondazione Policlinico Universitario "A. Gemelli" IRCCS, 00186 Roma, Italy.

Jacopo Lenkowicz (J)

Istituto di Radiologia, Università Cattolica del Sacro Cuore, 00186 Rome, Italy.

Carlotta Masciocchi (C)

Fondazione Policlinico Universitario "A. Gemelli" IRCCS, 00186 Roma, Italy.

Stefano Patarnello (S)

Fondazione Policlinico Universitario "A. Gemelli" IRCCS, 00186 Roma, Italy.

Gianluca Franceschini (G)

Dipartimento di Scienze della Salute della Donna e del Bambino e di Sanità Pubblica, UOC di Chirurgia Senologica, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, 00186 Roma, Italy.
Istituto di Semeiotica Chirurgica, Università Cattolica del Sacro Cuore, 00186 Rome, Italy.

Maria Antonietta Gambacorta (MA)

Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, UOC di Radioterapia Oncologica, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, 00186 Rome, Italy.
Istituto di Radiologia, Università Cattolica del Sacro Cuore, 00186 Rome, Italy.

Riccardo Masetti (R)

Dipartimento di Scienze della Salute della Donna e del Bambino e di Sanità Pubblica, UOC di Chirurgia Senologica, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, 00186 Roma, Italy.
Istituto di Semeiotica Chirurgica, Università Cattolica del Sacro Cuore, 00186 Rome, Italy.

Vincenzo Valentini (V)

Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, UOC di Radioterapia Oncologica, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, 00186 Rome, Italy.
Istituto di Radiologia, Università Cattolica del Sacro Cuore, 00186 Rome, Italy.

Classifications MeSH