Kirkiin: A New Toxic Type 2 Ribosome-Inactivating Protein from the Caudex of
Antineoplastic Agents, Phytogenic
/ isolation & purification
Cell Line, Tumor
Cell Survival
/ drug effects
Erythrocyte Aggregation
/ drug effects
Humans
Molecular Weight
Neuroblastoma
/ drug therapy
Passifloraceae
/ enzymology
Protein Biosynthesis
/ drug effects
Protein Synthesis Inhibitors
/ isolation & purification
Ribosome Inactivating Proteins, Type 2
/ isolation & purification
Ribosomes
/ drug effects
Adenia
apoptosis
kirkiin
lectins
neuroblastoma
ribosome-inactivating proteins
ricin
toxic enzymes
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
22 01 2021
22 01 2021
Historique:
received:
29
12
2020
revised:
18
01
2021
accepted:
19
01
2021
entrez:
27
1
2021
pubmed:
28
1
2021
medline:
2
7
2021
Statut:
epublish
Résumé
Ribosome-inactivating proteins (RIPs) are plant toxins that irreversibly damage ribosomes and other substrates, thus causing cell death. RIPs are classified in type 1 RIPs, single-chain enzymatic proteins, and type 2 RIPs, consisting of active A chains, similar to type 1 RIPs, linked to lectin B chains, which enable the rapid internalization of the toxin into the cell. For this reason, many type 2 RIPs are very cytotoxic, ricin, volkensin and stenodactylin being the most toxic ones. From the caudex of
Identifiants
pubmed: 33499082
pii: toxins13020081
doi: 10.3390/toxins13020081
pmc: PMC7912562
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Protein Synthesis Inhibitors
0
Ribosome Inactivating Proteins, Type 2
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fondazione CARISBO
ID : Project 2019.0539
Organisme : (Consejería de Educación, Junta de Castilla y León) to the GIR ProtIBio
ID : Grant VA033G19
Organisme : Pallotti Legacies for Cancer Research
ID : no
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