Antiviral Activity of Ribosome-Inactivating Proteins.
Animals
Antiviral Agents
/ isolation & purification
Humans
Pest Control, Biological
Plant Diseases
/ genetics
Plants, Genetically Modified
/ enzymology
Protein Synthesis Inhibitors
/ isolation & purification
Ribosome Inactivating Proteins
/ isolation & purification
Toxins, Biological
/ isolation & purification
Virus Diseases
/ drug therapy
Viruses
/ drug effects
adenine polynucleotide glycosylase
antiviral therapy
human virus
immunotoxin
rRNA glycosylase (EC 3.2.2.22)
ribosome-inactivating protein (RIP)
virus-resistant transgenic plant (VRTP)
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
22 01 2021
22 01 2021
Historique:
received:
22
12
2020
revised:
14
01
2021
accepted:
20
01
2021
entrez:
27
1
2021
pubmed:
28
1
2021
medline:
2
7
2021
Statut:
epublish
Résumé
Ribosome-inactivating proteins (RIPs) are rRNA N-glycosylases from plants (EC 3.2.2.22) that inactivate ribosomes thus inhibiting protein synthesis. The antiviral properties of RIPs have been investigated for more than four decades. However, interest in these proteins is rising due to the emergence of infectious diseases caused by new viruses and the difficulty in treating viral infections. On the other hand, there is a growing need to control crop diseases without resorting to the use of phytosanitary products which are very harmful to the environment and in this respect, RIPs have been shown as a promising tool that can be used to obtain transgenic plants resistant to viruses. The way in which RIPs exert their antiviral effect continues to be the subject of intense research and several mechanisms of action have been proposed. The purpose of this review is to examine the research studies that deal with this matter, placing special emphasis on the most recent findings.
Identifiants
pubmed: 33499086
pii: toxins13020080
doi: 10.3390/toxins13020080
pmc: PMC7912582
pii:
doi:
Substances chimiques
Antiviral Agents
0
Protein Synthesis Inhibitors
0
Toxins, Biological
0
Ribosome Inactivating Proteins
EC 3.2.2.22
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Consejería de Educación, Junta de Castilla y León
ID : VA033G19
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