Native-like SARS-CoV-2 spike glycoprotein expressed by ChAdOx1 nCoV-19/AZD1222 vaccine.


Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
19 Jan 2021
Historique:
entrez: 27 1 2021
pubmed: 28 1 2021
medline: 28 1 2021
Statut: epublish

Résumé

Vaccine development against the SARS-CoV-2 virus focuses on the principal target of the neutralizing immune response, the spike (S) glycoprotein. Adenovirus-vectored vaccines offer an effective platform for the delivery of viral antigen, but it is important for the generation of neutralizing antibodies that they produce appropriately processed and assembled viral antigen that mimics that observed on the SARS-CoV-2 virus. Here, we describe the structure, conformation and glycosylation of the S protein derived from the adenovirus-vectored ChAdOx1 nCoV-19/AZD1222 vaccine. We demonstrate native-like post-translational processing and assembly, and reveal the expression of S proteins on the surface of cells adopting the trimeric prefusion conformation. The data presented here confirms the use of ChAdOx1 adenovirus vectors as a leading platform technology for SARS-CoV-2 vaccines.

Identifiants

pubmed: 33501433
doi: 10.1101/2021.01.15.426463
pmc: PMC7836103
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIAID NIH HHS
ID : P50 AI150481
Pays : United States

Commentaires et corrections

Type : UpdateIn

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Auteurs

Yasunori Watanabe (Y)

School of Biological Sciences, University of Southampton, Southampton, SO17 1BJ, UK.
Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.

Luiza Mendonça (L)

Division of Structural Biology, University of Oxford, Wellcome Centre for Human Genetics, Oxford, OX3 7BN, UK.

Elizabeth R Allen (ER)

The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Andrew Howe (A)

Electron Bio-imaging Centre, Diamond Light Source, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.

Mercede Lee (M)

The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Joel D Allen (JD)

School of Biological Sciences, University of Southampton, Southampton, SO17 1BJ, UK.

Himanshi Chawla (H)

School of Biological Sciences, University of Southampton, Southampton, SO17 1BJ, UK.

David Pulido (D)

The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Francesca Donnellan (F)

The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Hannah Davies (H)

The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Marta Ulaszewska (M)

The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Sandra Belij-Rammerstorfer (S)

The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
NIHR Oxford Biomedical Research Centre, Oxford, UK.

Susan Morris (S)

The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Anna-Sophia Krebs (AS)

Division of Structural Biology, University of Oxford, Wellcome Centre for Human Genetics, Oxford, OX3 7BN, UK.

Wanwisa Dejnirattisai (W)

The Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

Juthathip Mongkolsapaya (J)

The Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Dengue Hemorrhagic Fever Research Unit, Office for Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Chinese Academy of Medical Science(CAMS) Oxford Institute (COI), University of Oxford, Oxford, U.K.

Piyada Supasa (P)

The Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

Gavin R Screaton (GR)

The Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.
Division of Medical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.

Catherine M Green (CM)

The Wellcome Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

Teresa Lambe (T)

The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
NIHR Oxford Biomedical Research Centre, Oxford, UK.

Peijun Zhang (P)

Division of Structural Biology, University of Oxford, Wellcome Centre for Human Genetics, Oxford, OX3 7BN, UK.
Electron Bio-imaging Centre, Diamond Light Source, Harwell Science and Innovation Campus, Didcot, OX11 0DE, UK.

Sarah C Gilbert (SC)

The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
NIHR Oxford Biomedical Research Centre, Oxford, UK.

Max Crispin (M)

School of Biological Sciences, University of Southampton, Southampton, SO17 1BJ, UK.

Classifications MeSH